Protein Alignment AP-2alpha and ap2a2

DIOPT Version :10

• Sequence 1: NP_995607.1
• Gene: AP-2alpha / 33211
• FlyBaseID: FBgn0264855
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: XP_031755830.1
• Gene: ap2a2 / 407867
• XenbaseID: XB-GENE-486024
• Length: 1011
• Species: Xenopus tropicalis
• Alignment Length: 996
• Identity: 646/996 - (64%)
• Similarity: 761/996 - (76%)
• Gaps: 84/996 - (8%)

  Fly    34 CKSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNK 98
            |||||||:||||||||||||||||||.||||.|||||||||||||||||||||||||||||||||
 Frog    23 CKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNK 87

  Fly    99 YSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIP 163
            |:||||||||||||||:||:|||||..:|||||.||||..:.|||.||||:|||:|||:|:.|||
 Frog    88 YTEKQIGYLFISVLVNSNSELIRLINNAIKNDLSSRNPTFMGLALHCIANVGSREMAEAFAGEIP 152

  Fly   164 KLLVSGDTMDVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKR 228
            ::||:|||||.||||||||||||:|:|||::...|||||::|||||||:||||||||||..|.::
 Frog   153 RILVAGDTMDSVKQSAALCLLRLYRTSPDLVLTNEWTSRVVHLLNDQHLGVVTAATSLITTLAQK 217

  Fly   229 NPDEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLN 293
            ||:|:|..|:|||||||||||::.|||||||||||||||||||||||||.| |..|:..||.||.
 Frog   218 NPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCY-PPPEDPAVRGRLT 281

  Fly   294 ETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNLR 358
            |.|||||||||||||||||||||||||||||||:|||:.||||||||||||||||||.:||||||
 Frog   282 ECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIYHDSEPNLLVRACNQLGQFLQHRETNLR 346

  Fly   359 YLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEMLN 423
            ||||||||.||:||||||.||.|.|.||.::|.|:||||||.|||||||||||.||::||.|||:
 Frog   347 YLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAQQIVAEMLS 411

  Fly   424 YLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEVQ 488
            ||||||||||||:||||||||||||.|||||||.|||||||||||||||||||||||||||::||
 Frog   412 YLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQ 476

  Fly   489 GYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDSRSAPLVQFKLLHSKYHLCSPMTRALL 553
            |||||||||||||||||||:||||||||||||||||||.||:||:||.|||||:||||..|||||
 Frog   477 GYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFNLLHSKFHLCSVPTRALL 541

  Fly   554 LSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSIVASTDVLATVLEEMPSFP 618
            ||.|||||||||||:|.||||.|..|.||:||.||||||.|||:||.:||.|:|||||||||.||
 Frog   542 LSAYIKFINLFPEIKTTIQDVLRSDSQLRNADVELQQRAVEYLRLSSIASNDILATVLEEMPPFP 606

  Fly   619 ERESSILAVLKKKK-PGRVPE-NEIRESKS---------PAPLTSAAQ----------------- 655
            ||||||||.||||| |..|.: .|.::.||         .|||::..|
 Frog   607 ERESSILAKLKKKKGPSTVTDLEETKKEKSNSDLNGITEHAPLSTTQQPVFEDKATYAVRQRPLS 671

  Fly   656 --------NNALVNNSHSKL-------NNSNANTDLLGLSTPPSNNIGSGSNSNST--------L 697
                    :.:|.:.:..::       :..:.:.|||||..      .|||:|..|        |
 Frog   672 LLVPTLSSSQSLYSGTSHRVAALPFCQSTPSPSADLLGLGA------ASGSSSTPTTAPSAGSLL 730

  Fly   698 IDVLG--------------DMYGSN--------SNNNSSAVYNTK----KFLFKNNGVLFENEML 736
            :||..              |.:.|:        |.....:|.|.:    ||:.|||||||||::|
 Frog   731 VDVFAEPSLPVAAVTTEADDNFPSDVQTPLEGASGEPDPSVDNAEDFFDKFICKNNGVLFENQLL 795

  Fly   737 QIGVKSEFRQNLGRLGLFYGNKTQVPLTNFNPVLQWSAEDALKLNVQMKVVEPTLEAGAQIQQLL 801
            |||:||||||||||:.:|:|||......||...|..|.|.:..||:|.|..|||::.|||:||::
 Frog   796 QIGIKSEFRQNLGRMFIFFGNKMSSQFQNFTTTLICSDELSASLNLQSKPAEPTIDGGAQVQQVV 860

  Fly   802 TAECIEDYADAPTIEISFRYNGTQQKFSIKLPLSVNKFFEPTEMNAESFFARWKNLSGEQQRSQK 866
            ..||::::.|.|.:.|.|||.|..|..|:|||:::||||:|||||::.||.|||.||...|..||
 Frog   861 NVECVQEFTDLPLLNIQFRYGGAFQNVSVKLPITLNKFFQPTEMNSQDFFQRWKQLSSPNQEVQK 925

  Fly   867 VFKAAQPLDLPGARNKLMGFGMQLLDQVDPNPDNMVCAGIIHTQSQQVGCLMRLEPNKQAQMFRL 931
            :|||..|:|....:.:|:|||..::|.|||||.|.|.||||..:::|||||:|||||:||||:||
 Frog   926 IFKAKNPMDTDITKARLIGFGPAVMDNVDPNPSNYVAAGIIQAKTRQVGCLLRLEPNEQAQMYRL 990

  Fly   932 TVRASKETVTREICDLLTDQF 952
            |:|.|||.|::.:||||::||
 Frog   991 TIRTSKEEVSQTLCDLLSEQF 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..603	CDD:396262	457/562 (81%)
		Alpha_adaptinC2	730..839	CDD:197886	54/108 (50%)
		Alpha_adaptin_C	839..947	CDD:426707	61/107 (57%)
ap2a2	XP_031755830.1	Adaptin_N	29..591	CDD:396262	457/562 (81%)
		HEAT repeat	332..355	CDD:293787	20/22 (91%)
		HEAT repeat	369..398	CDD:293787	20/28 (71%)
		HEAT repeat	408..434	CDD:293787	23/25 (92%)
		Alpha_adaptinC2	789..892	CDD:197886	51/102 (50%)
		Alpha_adaptin_C	898..1006	CDD:426707	61/107 (57%)