DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-2alpha and ap1g1

DIOPT Version :9

Sequence 1:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	XP_017212304.1	Gene:	ap1g1 / 324466	ZFINID:	ZDB-GENE-030131-3187	Length:	822	Species:	Danio rerio

Alignment Length:	877	Identity:	222/877 - (25%)
Similarity:	410/877 - (46%)	Gaps:	145/877 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKY 99
            :::..|.:.|.||.|.|||.|:.:   |...:.:.|.|||::.:||:...||.:|.:.|::|.|:
Zfish    18 RTQAEEREMIQKECAAIRSSFREE---DNTYRCRNVAKLLYMHMLGYPAHFGQLECLKLIASQKF 79

  Fly   100 SEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPK 164
            ::|:||||...:|::...|:..|:...|||||.........|||..:..:||.:|....:.|:.|
Zfish    80 TDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQYVQGLALCTLGCMGSSEMCRDLAGEVEK 144

  Fly   165 LLVSGDTMDVVKQSAALCLLRLFRSSPDI----IPGGEWTSRIIHLLNDQHMGVVTAATSLIDAL 225
            ||.:.::  .:::.||||.:.:.|..|::    :|..:      :||::::.||:..:..|:..:
Zfish   145 LLKTSNS--YLRKKAALCAVHVIRKVPELMEMFLPATK------NLLSEKNHGVLHTSVVLLTEM 201

  Fly   226 VKRNPD------EYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTE 284
            .:|:||      :.:..|...|..|..::.:.|:...|.:  .:..|:|.|::||||:......:
Zfish   202 CERSPDMLSHFRKNEKLVPQLVRILKNLIMSGYSPEHDVS--GISDPFLQVRILRLLRILGKGDD 264

  Fly   285 EAGVRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQF 349
            ::      :|.:..||.:.....::.|    |..||:|:|.:..|:...||..|.|.|.|.||:|
Zfish   265 DS------SEAMNDILAQVATNTETSK----NVGNAILYETVLTIMDIKSESGLRVLAINILGRF 319

  Fly   350 LSNRETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNA 414
            |.|.:.|:||:||.|:  |.|.:..|..|::|:..::..:| :.|||:::.|::|.:|:.:..|.
Zfish   320 LLNNDKNIRYVALTSL--LKTVQTDHNAVQRHRSTIVDCLK-DLDVSIKRRAMELSFALVNGNNI 381

  Fly   415 EEIVQEMLNYLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQ 479
            ..:::|:|.:|::.|...:.:....:.:.|||||....|::|.|:.::..||.||.::....:||
Zfish   382 RGMMKELLYFLDSCDPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDSVPNLIQ 446

  Fly   480 IVINREEVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGN-LIAGDSRSAPLVQFK------- 536
            ::.|..|:..|..:.:::||......:.:|:|..:.:||:|: |::|.......:|..
Zfish   447 LITNSVEMHAYTVQRLYKALLDDISQQPLVQVASWCIGEYGDLLVSGQCEEEEPIQVSEDEVLDV 511

  Fly   537 ---LLHSKYHLCSPMTRALLLSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQL 598
               ||.|  :|.:|:||...|:..:|....|..: ..|:.|...:.:  |.|.||||||.||..|
Zfish   512 LEGLLVS--NLSAPVTRGYSLTAIMKLSTRFSSV-NRIKKVVSIYGS--SIDVELQQRAVEYNAL 571

  Fly   599 SIVASTDVLATVLEEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPAPL--TSAAQNNALVN 661
                              |.:.:....|:|:     |:|..|...:..||.:  |:...:..:::
Zfish   572 ------------------FKKYDHMRPALLE-----RMPIMEKSATNGPAEIVQTNGETDAPILD 613

  Fly   662 NSH-----SKLNNSNANTDLLG--------LSTPPSNNIGSGSNSNSTLIDVLGDMY---GSNSN 710
            ..|     ..::.:|...||||        .:|.|:....:|..    |:|:|||:.   |....
Zfish   614 TKHPPNIPQPISQANDLLDLLGGNDVVPVIQTTAPTKPASAGGE----LLDLLGDLSLTGGPAPT 674

  Fly   711 NNSSAVYNTKKFLFKNNGV----LFENEMLQI---------GVKSEF-------RQNLGRLGLFY 755
            ...|...:...||.  :|:    ||.:....|         |:|.||       ..|:..:.:..
Zfish   675 PAPSVPMSQPPFLL--DGLTSQPLFNDIGAGIPPMTAYNKNGLKIEFTFERSNPNPNIAVITIHA 737

  Fly   756 GNKTQVPLTNFNPVLQWSAEDALKLNV--QMKVVEPTLEAGA--QIQQLLTAECIEDYADAPTIE 816
            .|.|:|.:|.|  |.|.:.....:|.:  ....|.|.|..|:  |:.::|
Zfish   738 TNTTEVDMTEF--VFQAAVPKTFQLQLLSPSSNVVPALNQGSVTQVIRVL--------------- 785

  Fly   817 ISFRYNGTQQKFSIKLPLSVNKFFEPTEMNAE 848
                 |..:|:..:::.|:......|.:..||
Zfish   786 -----NPQKQQLRMRIKLTYTHKGSPVQDLAE 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	165/578 (29%)
		Alpha_adaptinC2	730..839	CDD:197886	25/128 (20%)
		Alpha_adaptin_C	839..947	CDD:280460	3/10 (30%)
ap1g1	XP_017212304.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53727
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920