DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-2alpha and AP-1gamma

DIOPT Version :9

Sequence 1:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster

Alignment Length:	888	Identity:	217/888 - (24%)
Similarity:	369/888 - (41%)	Gaps:	220/888 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 INKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYSEKQIGYLF 108
            :|||.|.|||.|:.:   |...:.:.:.|||:|.:||:...||.:|.:.|.:|.::::|:||||.
  Fly    68 VNKECAYIRSTFREE---DSVWRCRNIAKLLYIHMLGYPAHFGQLECLKLTASTRFTDKRIGYLG 129

  Fly   109 ISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKLLVSGDTMD 173
            ..:|::...|:..||...:||||.|.....|.|||..:..|.|.:||...::|:.:|:.|.:|
  Fly   130 AMLLLDERQDVHLLITNCLKNDLNSSTQFVVGLALCTLGAIASPEMARDLASEVERLMKSPNT-- 192

  Fly   174 VVKQSAALCLLRLFRSSPDI----IPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNPDEY- 233
            .:::.|.||..|:.|..|::    :|...      .||::::.|::....:||..:.:.:.|..
  Fly   193 YIRKKATLCAFRVIRRVPELMEIFLPATR------SLLSEKNHGILITGVTLITEMCENSSDTLM 251

  Fly   234 --------KGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQ---NYNPVTEEAG 287
                    :..|...|..|..::...|:...|.:  .|..|:|.||:||||:   :.:|...||
  Fly   252 HFKKDSGNREIVPNLVRILKNLILGGYSPEHDVS--GVSDPFLQVKILRLLRILGHNDPDASEA- 313

  Fly   288 VRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSN 352
                :|:.|..:   |.....||     |..|.:|:|.:..|:...||..|.|.|.|.||:||.|
  Fly   314 ----MNDILAQV---ATNTETSK-----NVGNTILYETVLSIMDIRSEGGLRVLAVNILGRFLLN 366

  Fly   353 RETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEI 417
            .:.|:||:||.::  |.|.......|::|:..::..:| :.|||:|:.|::|.:|:.:..|...:
  Fly   367 SDKNIRYVALNTL--LRTVHADTSAVQRHRTTILECLK-DPDVSIRRRAMELSFALINAQNIRTM 428

  Fly   418 VQEMLNYLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVI 482
            .:|:|.:||.||...:.:....:.:.||:|:....|::|..|:::..||:||.::|....||:|.
  Fly   429 TKELLLFLEKADAEFKAQCSSGMILAAERYSPTTRWHLDTQLSVLIAAGNYVRDDVVSSTIQLVS 493

  Fly   483 NRE-EVQGYAAKTVFEALQ-APACHEN--MVKVGGYILGEFGNL--------------------- 522
            :.. ..|.|.....:|:|| |..|.:.  :::|..:.:||:|:|
  Fly   494 SSPVPEQTYITNRFWESLQVANHCEDKQPLLQVAVWAIGEYGDLFMYGANEDEFERPTESDLIAV 558

  Fly   523 ---------IAGDSRSAPLVQFKLLHSKYHLCSPMTRALLLSTYIKFINLFPEIRTNIQDVFRQH 578
                     ::..|:...||....|.::...|....:||:.|                   |..|
  Fly   559 YYKFLTSAQVSTTSKQYALVSLAKLSTRLQQCVEEIQALITS-------------------FGSH 604

  Fly   579 SNLRSADAELQQRASEYLQLSIVASTDVLATVLEEMP-----------------SFPERESSILA 626
            .|:     :||||..|:.|| ......:...:||:||                 ||.:....::
  Fly   605 LNV-----DLQQRGVEFTQL-FGHYKHLRPPLLEKMPAMQISRISSQNGESGGGSFDDNSPDVI- 662

  Fly   627 VLKKKKPGRVPENEIR------ESKSPAPLTSAAQNNAL-----------------------VNN 662
                       ||.:.      .|...:.:.:...|..:                       ::|
  Fly   663 -----------ENGVEGGGGGGHSLIESNMNTLGDNTNILLDLLGSTDLSAGGAGDLVAATDLSN 716

  Fly   663 SHSKLNNSNAN------------TDL--LGLSTPPSNNIG--SGSNSNSTLIDVLGDMYGSNSNN 711
            :..|.|:.|||            .||  |.||.|.|...|  :|......::.::||       |
  Fly   717 AVHKKNSRNANDVVAPVSNNQDLLDLLDLDLSAPSSTTTGAPAGGGGGGGIVALVGD-------N 774

  Fly   712 NSSAVYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFNPVLQW---- 772
            |.|:..|....|    |.|                :||..|....:...:| ||.|.:...
  Fly   775 NQSSAANMNNML----GGL----------------DLGGFGSGLDSSASIP-TNGNDLASMLGGL 818

  Fly   773 SAEDALKLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADA-PT 814
            .|..|         ..|:|.|.|.:..|:........||. ||
  Fly   819 GAPPA---------ASPSLAASAPVGNLIDGHAGSLLADLNPT 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	163/603 (27%)
		Alpha_adaptinC2	730..839	CDD:197886	19/90 (21%)
		Alpha_adaptin_C	839..947	CDD:280460
AP-1gamma	NP_788891.2	Adaptin_N	68..624	CDD:279882	165/609 (27%)
AP-1gamma	NP_788891.2	Alpha_adaptinC2	869..972	CDD:197886
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22780
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840