Protein Alignment AP-2alpha and Ap3d1

DIOPT Version :10

• Sequence 1: NP_995607.1
• Gene: AP-2alpha / 33211
• FlyBaseID: FBgn0264855
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: XP_063119492.1
• Gene: Ap3d1 / 314633
• RGDID: 1308659
• Length: 1227
• Species: Rattus norvegicus
• Alignment Length: 925
• Identity: 191/925 - (20%)
• Similarity: 375/925 - (40%)
• Gaps: 195/925 - (21%)

  Fly    37 KEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYSE 101
            ||.|.|.|::.:..|:.:.|.|...   .|...||||.::.:||:||.:.....:.::|::|::.
  Rat    29 KEDEAKYISQCIDEIKQELKQDNIA---VKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTF 90

  Fly   102 KQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKLL 166
            |::|||..|...:..:|:|.|....|:.||.|.:.....:||..::...:.|:|...:|:|..|:
  Rat    91 KRVGYLAASQCFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLM 155

  Fly   167 VSGDTMDVVKQSAALCLLRLFRSSPDII-PGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNP 230
              ..|...:::.|.|.:.::|...|:.: |.   ..|:...|.|...||.:||.::|..|.:|||
  Rat   156 --SHTKPYIRKKAVLIMYKVFLKYPESLRPA---FPRLKEKLEDPDPGVQSAAVNVICELARRNP 215

  Fly   231 DEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLNET 295
            ..|.....|    ..:::|:|..:            |:.:|:::|.....|:....|  .:|.|.
  Rat   216 KNYLSLAPL----FFKLMTSSTNN------------WVLIKIIKLFGALTPLEPRLG--KKLIEP 262

  Fly   296 LETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIH-----SDSEPN--LLVRACNQ-LGQFLSN 352
            |..::             ||.:..::|:|.:|.:|.     |...||  ..::.|.| |...:.:
  Rat   263 LTNLI-------------HSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIED 314

  Fly   353 RETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEI 417
            .:.||:||.|.:|..:..:.  .:.|:.|:::::..:. :||.|:|..|:||||.|..:.|..||
  Rat   315 SDQNLKYLGLLAMSKILKTH--PKSVQSHKDLILQCLD-DKDESIRLRALDLLYGMVSKKNLMEI 376

  Fly   418 VQEMLNYLETAD-YSIREEMVLKVAILAE----KYATDYTWYVDVILNLIRIAGDYVSEEVWYRV 477
            |::::.:::.|: .:.|:|::.|:..:..    ::.|::.||:.:::.|.|:.|......:..::
  Rat   377 VKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQHITNFEWYISILVELTRLEGTRHGHLIAAQM 441

  Fly   478 IQIVINREEVQGYAAKTVFEALQ-----APACHEN----MVKVGGYILGEFGNLIAGDSRSAPLV 533
            :.:.|..:.::.:|...:...|.     |.:...|    ::....:|.|||...:.|..::..
  Rat   442 LDVAIRVKAIRKFAVSQMSSLLDSAHLVASSTQRNGICEVLYAAAWICGEFSEHLQGPQQTLE-- 504

  Fly   534 QFKLLHSKYHLCSPMTRALLLSTYIKFINLFPEIRTNIQD-----------VFRQHSNLRSADAE 587
              .:|..|........:|:.:...:|......:.:....|           |.|....::|||.|
  Rat   505 --AMLRPKVTTLPGHIQAVYVQNVVKLYASILQQKEQAADTEGAQEVTQLLVERLPQFVQSADLE 567

  Fly   588 LQQRASEYLQLSIVASTDVL----ATVLEEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPA 648
            :|:|||..|||  |.....|    ..|.||:.:....|.:.:|...:||               .
  Rat   568 VQERASCILQL--VKHVQKLQAKGVPVAEEVSALFAGELNPVAPKAQKK---------------V 615

  Fly   649 PLTSAAQNNALVNNSHSKLNNSNANTDLLGLSTPPSNNIGSGSNSNSTLIDVLGDMYGSNSNNNS 713
            |:......:|.:|.                   |||::                    .:.:...
  Rat   616 PVPEGLDLDAWINE-------------------PPSDS--------------------ESEDEKP 641

  Fly   714 SAVYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFN--------PVL 770
            .|:::.::..........|:|. ::..:.|.|:.......||...:..|...:.        ||:
  Rat   642 KAIFHEEEPRHTRRRQPEEDEE-ELARRREARKQEQANNPFYIKSSPSPQKRYQDAPGVEHIPVV 705

  Fly   771 QWSAEDALKLNVQMKVVEPTL----------------------------EAGAQIQQLLTAECIE 807
            |      :.|:|.:||  |.:                            |.|.:....|..|..|
  Rat   706 Q------IDLSVPLKV--PGMPMSDQYVKLEEQRRHRQRLEKDKKRKKKEKGKRRHSSLPTESDE 762

  Fly   808 DYADAPTIEISFRYNGTQQKFSIKLP-----LSVNKFFEPTEMNAESFFARWKNLSGEQQRSQKV 867
            |.|.|..::|.     |::.....||     ...|..:...:::.:...|..:.|..::.|:.:.
  Rat   763 DIAPAQRVDII-----TEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPVQKHRNAET 822

  Fly   868 FKAAQPLDLPGARNK 882
            .|:.:...:||...|
  Rat   823 VKSPEKEGVPGVEKK 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..603	CDD:396262	139/596 (23%)
		Alpha_adaptinC2	730..839	CDD:197886	28/149 (19%)
		Alpha_adaptin_C	839..947	CDD:426707	7/44 (16%)
Ap3d1	XP_063119492.1	None