DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP-2alpha and Ap3d1

DIOPT Version :9

Sequence 1:NP_995607.1 Gene:AP-2alpha / 33211 FlyBaseID:FBgn0264855 Length:952 Species:Drosophila melanogaster
Sequence 2:NP_001094189.1 Gene:Ap3d1 / 314633 RGDID:1308659 Length:1204 Species:Rattus norvegicus


Alignment Length:925 Identity:191/925 - (20%)
Similarity:375/925 - (40%) Gaps:195/925 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 KEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYSE 101
            ||.|.|.|::.:..|:.:.|.|...   .|...||||.::.:||:||.:.....:.::|::|::.
  Rat    29 KEDEAKYISQCIDEIKQELKQDNIA---VKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTF 90

  Fly   102 KQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKLL 166
            |::|||..|...:..:|:|.|....|:.||.|.:.....:||..::...:.|:|...:|:|..|:
  Rat    91 KRVGYLAASQCFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLM 155

  Fly   167 VSGDTMDVVKQSAALCLLRLFRSSPDII-PGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNP 230
              ..|...:::.|.|.:.::|...|:.: |.   ..|:...|.|...||.:||.::|..|.:|||
  Rat   156 --SHTKPYIRKKAVLIMYKVFLKYPESLRPA---FPRLKEKLEDPDPGVQSAAVNVICELARRNP 215

  Fly   231 DEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLNET 295
            ..|.....|    ..:::|:|..:            |:.:|:::|.....|:....|  .:|.|.
  Rat   216 KNYLSLAPL----FFKLMTSSTNN------------WVLIKIIKLFGALTPLEPRLG--KKLIEP 262

  Fly   296 LETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIH-----SDSEPN--LLVRACNQ-LGQFLSN 352
            |..::             ||.:..::|:|.:|.:|.     |...||  ..::.|.| |...:.:
  Rat   263 LTNLI-------------HSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIED 314

  Fly   353 RETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEI 417
            .:.||:||.|.:|..:..:.  .:.|:.|:::::..:. :||.|:|..|:||||.|..:.|..||
  Rat   315 SDQNLKYLGLLAMSKILKTH--PKSVQSHKDLILQCLD-DKDESIRLRALDLLYGMVSKKNLMEI 376

  Fly   418 VQEMLNYLETAD-YSIREEMVLKVAILAE----KYATDYTWYVDVILNLIRIAGDYVSEEVWYRV 477
            |::::.:::.|: .:.|:|::.|:..:..    ::.|::.||:.:::.|.|:.|......:..::
  Rat   377 VKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQHITNFEWYISILVELTRLEGTRHGHLIAAQM 441

  Fly   478 IQIVINREEVQGYAAKTVFEALQ-----APACHEN----MVKVGGYILGEFGNLIAGDSRSAPLV 533
            :.:.|..:.::.:|...:...|.     |.:...|    ::....:|.|||...:.|..::..  
  Rat   442 LDVAIRVKAIRKFAVSQMSSLLDSAHLVASSTQRNGICEVLYAAAWICGEFSEHLQGPQQTLE-- 504

  Fly   534 QFKLLHSKYHLCSPMTRALLLSTYIKFINLFPEIRTNIQD-----------VFRQHSNLRSADAE 587
              .:|..|........:|:.:...:|......:.:....|           |.|....::|||.|
  Rat   505 --AMLRPKVTTLPGHIQAVYVQNVVKLYASILQQKEQAADTEGAQEVTQLLVERLPQFVQSADLE 567

  Fly   588 LQQRASEYLQLSIVASTDVL----ATVLEEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPA 648
            :|:|||..|||  |.....|    ..|.||:.:....|.:.:|...:||               .
  Rat   568 VQERASCILQL--VKHVQKLQAKGVPVAEEVSALFAGELNPVAPKAQKK---------------V 615

  Fly   649 PLTSAAQNNALVNNSHSKLNNSNANTDLLGLSTPPSNNIGSGSNSNSTLIDVLGDMYGSNSNNNS 713
            |:......:|.:|.                   |||::                    .:.:...
  Rat   616 PVPEGLDLDAWINE-------------------PPSDS--------------------ESEDEKP 641

  Fly   714 SAVYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFN--------PVL 770
            .|:::.::..........|:|. ::..:.|.|:.......||...:..|...:.        ||:
  Rat   642 KAIFHEEEPRHTRRRQPEEDEE-ELARRREARKQEQANNPFYIKSSPSPQKRYQDAPGVEHIPVV 705

  Fly   771 QWSAEDALKLNVQMKVVEPTL----------------------------EAGAQIQQLLTAECIE 807
            |      :.|:|.:||  |.:                            |.|.:....|..|..|
  Rat   706 Q------IDLSVPLKV--PGMPMSDQYVKLEEQRRHRQRLEKDKKRKKKEKGKRRHSSLPTESDE 762

  Fly   808 DYADAPTIEISFRYNGTQQKFSIKLP-----LSVNKFFEPTEMNAESFFARWKNLSGEQQRSQKV 867
            |.|.|..::|.     |::.....||     ...|..:...:::.:...|..:.|..::.|:.:.
  Rat   763 DIAPAQRVDII-----TEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPVQKHRNAET 822

  Fly   868 FKAAQPLDLPGARNK 882
            .|:.:...:||...|
  Rat   823 VKSPEKEGVPGVEKK 837

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-2alphaNP_995607.1 Adaptin_N 40..598 CDD:279882 136/591 (23%)
Alpha_adaptinC2 730..839 CDD:197886 28/149 (19%)
Alpha_adaptin_C 839..947 CDD:280460 7/44 (16%)
Ap3d1NP_001094189.1 Adaptin_N 32..581 CDD:279882 139/596 (23%)
HEAT repeat 151..172 CDD:293787 5/22 (23%)
Cnd1 155..265 CDD:289487 30/132 (23%)
HEAT repeat 184..212 CDD:293787 9/30 (30%)
HEAT repeat 220..262 CDD:293787 9/59 (15%)
HEAT repeat 271..292 CDD:293787 4/20 (20%)
HEAT repeat 301..330 CDD:293787 9/28 (32%)
HEAT repeat 335..364 CDD:293787 8/29 (28%)
BLVR 661..803 CDD:283923 27/155 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG4354
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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