DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-2alpha and Ap2a1

DIOPT Version :9

Sequence 1:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001382021.1	Gene:	Ap2a1 / 308578	RGDID:	1306254	Length:	977	Species:	Rattus norvegicus

Alignment Length:	965	Identity:	632/965 - (65%)
Similarity:	740/965 - (76%)	Gaps:	56/965 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNK 98
            |||||||:||||||||||||||||||.||||.|||||||||||||||||||||||||||||||||
  Rat    23 CKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNK 87

  Fly    99 YSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIP 163
            |:||||||||||||||:||:|||||..:|||||.||||..:.|||.||||:|||:|.|:|:.:||
  Rat    88 YTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMGEAFAADIP 152

  Fly   164 KLLVSGDTMDVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKR 228
            ::||:||:||.||||||||||||:::|||::|.||||:|::||||||||||||||.|||..|.|:
  Rat   153 RILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVVTAAVSLITCLCKK 217

  Fly   229 NPDEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLN 293
            |||::|.||:||||||||||:::.|||||||||||||||||||||||||.| |..|:|.|:.||.
  Rat   218 NPDDFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLRLLQCY-PPPEDAAVKGRLV 281

  Fly   294 ETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNLR 358
            |.|||:|||||||||||||||||||||:|||.|:||||.||||||||||||||||||.:||||||
  Rat   282 ECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHYDSEPNLLVRACNQLGQFLQHRETNLR 346

  Fly   359 YLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEMLN 423
            ||||||||.||:||||||.||.|.:.||.::|.|:||||||.|.|||||||||.||::||.|||.
  Rat   347 YLALESMCTLASSEFSHEAVKTHIDTVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLR 411

  Fly   424 YLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEVQ 488
            |||||||:||||:||||||||||||.||:||||.||||||||||||||||||||:|||.||::||
  Rat   412 YLETADYAIREEIVLKVAILAEKYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQ 476

  Fly   489 GYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDSRSAPLVQFKLLHSKYHLCSPMTRALL 553
            ||||||||||||||||||||||||||||||||||||||.||:|.|||.|||||:||||..|||||
  Rat   477 GYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRALL 541

  Fly   554 LSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSIVASTDVLATVLEEMPSFP 618
            |||||||||||||.:..||.|.|..|.||:||.||||||.|||.||.|||||||||||||||.||
  Rat   542 LSTYIKFINLFPETKATIQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFP 606

  Fly   619 ERESSILAVLKKKK-PGRVPENEIRESKSPAPLTSAAQNNALVNNSHSKLNNSNANTDLLGLSTP 682
            ||||||||.||:|| ||..  :.:.:|:..   ||:...|..|..:.|.::..:.:.|||||...
  Rat   607 ERESSILAKLKRKKGPGAA--SALDDSRRD---TSSNDINGGVEPTPSNVSTPSPSADLLGLRAA 666

  Fly   683 PSNNIGSGSNSNSTLIDVLGDMYGSNSNNN----------------------------------- 712
            |...........:.|:||..|  |..:..:
  Rat   667 PPPAAPPAPVGGNLLVDVFSD--GPTAQPSLGPTPEEAFLSELEPPAPESPMTLLADPAPAADPG 729

  Fly   713 ----------SSAVYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFN 767
                      :..:.|  ||:.||:||||||::|||||||||||||||:.|||||||.|...:|.
  Rat   730 PEDIGPPIPEADELLN--KFVCKNSGVLFENQLLQIGVKSEFRQNLGRMYLFYGNKTSVQFQSFL 792

  Fly   768 PVLQWSAEDALKLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADAPTIEISFRYNGTQQKFSIKL 832
            |.:....:...:|.||.|.|...::.|||:||:|..||:.|:...|.:.:.|||.||.|..::||
  Rat   793 PTVVHPGDLQTQLAVQTKRVAAQVDGGAQVQQVLNIECLRDFLTPPLLSVRFRYGGTAQSLTLKL 857

  Fly   833 PLSVNKFFEPTEMNAESFFARWKNLSGEQQRSQKVFKAAQPLDLPGARNKLMGFGMQLLDQVDPN 897
            |:::||||:||||.|:.||.|||.||...|.:||:|||..|:|....:.||:|||..|||.||||
  Rat   858 PVTINKFFQPTEMAAQDFFQRWKQLSLPLQEAQKIFKANHPMDAEVTKAKLLGFGSALLDNVDPN 922

  Fly   898 PDNMVCAGIIHTQSQQVGCLMRLEPNKQAQMFRLTVRASKETVTREICDLLTDQF 952
            |:|.|.||||.|::.|||||:|||||.||||:|||:|.|||.|:|.:|:||..||
  Rat   923 PENFVGAGIIQTKALQVGCLLRLEPNAQAQMYRLTLRTSKEPVSRHLCELLAQQF 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	444/557 (80%)
		Alpha_adaptinC2	730..839	CDD:197886	54/108 (50%)
		Alpha_adaptin_C	839..947	CDD:280460	66/107 (62%)
Ap2a1	NP_001382021.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349231
Domainoid	1	1.000	898	1.000	Domainoid score	I46
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1290	1.000	Inparanoid score	I148
OMA	1	1.010	-	-		QHG53727
OrthoDB	1	1.010	-	-		D751651at2759
OrthoFinder	1	1.000	-	-		FOG0002465
OrthoInspector	1	1.000	-	-		otm46233
orthoMCL	1	0.900	-	-		OOG6_101447
Panther	1	1.100	-	-	O	PTHR22780
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1882
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910