DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP-2alpha and apl3

DIOPT Version :9

Sequence 1:NP_995607.1 Gene:AP-2alpha / 33211 FlyBaseID:FBgn0264855 Length:952 Species:Drosophila melanogaster
Sequence 2:NP_595595.1 Gene:apl3 / 2541162 PomBaseID:SPBC691.03c Length:878 Species:Schizosaccharomyces pombe


Alignment Length:926 Identity:329/926 - (35%)
Similarity:511/926 - (55%) Gaps:85/926 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 EVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYSEKQI 104
            |.||:|.|||.||:||: ..||..|.:||||.|||:|::||:.|.||||||..|||..|||||.|
pombe    25 EEKRVNVELAKIRAKFQ-SSTLSAYDRKKYVSKLLYIYMLGYPITFGHMEAAKLLSGTKYSEKLI 88

  Fly   105 GYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKLLVSG 169
            |||.:::|:|.|.:|::|:|.|||.||.|.:.:..:|||..|||||.|::.|:...:|.|||:|.
pombe    89 GYLAVALLLNENHELMKLVINSIKKDLLSHDSLQNSLALHTIANIGGRELCETVYYDIYKLLMSA 153

  Fly   170 DTMDVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNPDEYK 234
            ...::|:|.:||.||.::|..||:| ..||...|:.:|.|..:.|..|.::.::.:|.|.|...|
pombe   154 SNENIVRQKSALALLHIYRKFPDLI-NPEWFEPIVMILGDDDLNVSLAVSNFVNLIVIREPKYQK 217

  Fly   235 GCVNLAVSRLSRIV-TASYTDLQDYTYYFVPAPWLSVKLLRLL-----QNYNPVTEEAGVRARLN 293
            .....||.:|..|| ...|:  .||.||.||.|||.|.|.|:|     .:.||      .||.|.
pombe   218 FAYGKAVGKLKNIVFEHGYS--SDYLYYSVPCPWLQVNLCRILLACERPSDNP------TRATLI 274

  Fly   294 ETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNLR 358
            ..|:.||:.   |..:..||..||.||:|||||.|....|...:|..:..::|...::::|:|:|
pombe   275 RVLDRILSL---PNDNSNVQQVNAVNAILFEAIKLAFLVDESHSLYEKCMDRLADMIADKESNIR 336

  Fly   359 YLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEMLN 423
            |||.|:..:|.:...|...:|.::|:::.|::. ||||:|:.:::|||.|||..||:.||.::|.
pombe   337 YLAFETTAYLISCGHSITSLKHYKELILSSLRY-KDVSLRKKSLELLYMMCDEENAKLIVADLLQ 400

  Fly   424 YLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEVQ 488
            ||...|...:|:::.||||::|.:||||.|||||.:.|:||||....:.||::::.:::|.||:|
pombe   401 YLPHLDSVTQEDLISKVAIISETFATDYEWYVDVTIQLLRIAGKSADDGVWHQLVHVIVNNEEIQ 465

  Fly   489 GYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDSRSAPLVQFKLLHSKYHLCSPMTRALL 553
            .||.|.:|..||:...||.:||.|||:|||||:||.....|.|:.||..::.|.::.||.||.||
pombe   466 EYATKRLFSLLQSETIHECLVKAGGYVLGEFGHLITDYPDSQPVHQFSTIYRKLNVSSPSTRVLL 530

  Fly   554 LSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSIVASTDVLATVLEEMPSFP 618
            |:|.||..||.||:...|..||:::|.:  .:.|:||||.||||| :....|.|..|.:|:|.|.
pombe   531 LTTLIKLANLQPELNDRIAKVFQEYSTI--INPEVQQRACEYLQL-LKMPRDFLQLVCDEVPPFL 592

  Fly   619 ERESSILAVLKKKKPGRVPENEIRESKSPAPLTSAAQNNALVNNSHSKLNNSNANTDLLGLSTPP 683
            :..                    |:...|....|:..|  ||:.....:.|         :|.| 
pombe   593 DGN--------------------RDGVHPKSRPSSKVN--LVDTYPQTIPN---------VSKP- 625

  Fly   684 SNNIGSGSNSNSTLIDVLGDMYGSNSNNNSSAVYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNL 748
                       ||.|||       ...:.|:.:....:..:|:.|:|:::..:||||:||:..:.
pombe   626 -----------STPIDV-------PEYDISACLPGFYRLCWKDKGILYQDSQIQIGVRSEYHNSE 672

  Fly   749 GRLGLFYGNKTQVPLTNFNPVLQWSAEDALKLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADAP 813
            |.:.|:|.|:....|.:.:..|   .......::.....:..|.:|.|:||......:.:..:.|
pombe   673 GAIYLYYENRQSNTLKSLSSTL---IRTFSTFHLATTFQDTNLPSGVQLQQKYVMSGVNEIFEPP 734

  Fly   814 TIEISFRYNGTQQKFSIKLPLSVNKFFEPTEMNAESFFARWKNLSGEQQRSQKVF---KAAQPLD 875
            .|.:|: ..|..:...::||:.::||.:||..::..||..|..: |.::.:|..|   ...:.||
pombe   735 IIHVSY-VTGVIRSIDLQLPVLLSKFMKPTIFDSYDFFNHWGQM-GVEREAQLTFGLNSKDRKLD 797

  Fly   876 LPGARNKLMGFGMQLLDQVDPNPDNMVCAGIIHTQSQQVGCLMRLEPNKQAQMFRLTVRASK--- 937
            .......:.||...:...||....|:|.||||...:|.||||:|:|||.:..:.||::|::.   
pombe   798 AKRLTKIVSGFHWGICQNVDSIALNIVGAGIIRFGTQNVGCLLRIEPNYEQNLIRLSIRSTNTSI 862

  Fly   938 -ETVTREICDLLTDQF 952
             .|:.:|:.::|.:.|
pombe   863 ANTLAKEMQEILRNSF 878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-2alphaNP_995607.1 Adaptin_N 40..598 CDD:279882 242/563 (43%)
Alpha_adaptinC2 730..839 CDD:197886 24/108 (22%)
Alpha_adaptin_C 839..947 CDD:280460 35/114 (31%)
apl3NP_595595.1 Adaptin_N 25..578 CDD:279882 244/569 (43%)
Alpha_adaptinC2 654..753 CDD:197886 22/102 (22%)
Alpha_adaptin_C 759..868 CDD:280460 34/109 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 437 1.000 Domainoid score I78
eggNOG 1 0.900 - - E1_COG4354
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H5335
Inparanoid 1 1.050 537 1.000 Inparanoid score I208
OMA 1 1.010 - - QHG53727
OrthoFinder 1 1.000 - - FOG0002465
OrthoInspector 1 1.000 - - oto101961
orthoMCL 1 0.900 - - OOG6_101447
Panther 1 1.100 - - LDO PTHR22780
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R61
SonicParanoid 1 1.000 - - X1882
TreeFam 1 0.960 - -
1413.860

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