Protein Alignment AP-2alpha and AP4E1

DIOPT Version :9

• Sequence 1: NP_995607.1
• Gene: AP-2alpha / 33211
• FlyBaseID: FBgn0264855
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: NP_031373.2
• Gene: AP4E1 / 23431
• HGNCID: 573
• Length: 1137
• Species: Homo sapiens
• Alignment Length: 1156
• Identity: 243/1156 - (21%)
• Similarity: 460/1156 - (39%)
• Gaps: 320/1156 - (27%)

  Fly    36 SKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYS 100
            ||..|.|.|.:||:::::......|.....|:..| :|::..:||:|..||::.|:.|.......
Human    48 SKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMV-RLIYCEMLGYDASFGYIHAIKLAQQGNLL 111

  Fly   101 EKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKL 165
            ||::|||.:|:.::.:.:|:.|::.::..||||.|.|.|.:||..::.|...:|       ||.:
Human   112 EKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEM-------IPAV 169

  Fly   166 L-VSGDTM----DVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIHL-----LNDQHMGVVTAATS 220
            | :..|.:    ::|::.|.|.|.:....:|:.:       :.||:     |.|:.:||:.|:..
Human   170 LPLIEDKLQHSKEIVRRKAVLALYKFHLIAPNQV-------QHIHIKFRKALCDRDVGVMAASLH 227

  Fly   221 LIDALVKRNPDEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEE 285
            :...::|.|...||......|:.|.::|.....  .::.|:.||||||.::|||:|
Human   228 IYLRMIKENSSGYKDLTGSFVTILKQVVGGKLP--VEFNYHSVPAPWLQIQLLRIL--------- 281

  Fly   286 AGVRARLNE-TLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQF 349
             |:..:.:: |.|.:.:...|..:..::.| |...|:|||.::.:.....:..||.:|...:|:|
Human   282 -GLLGKDDQRTSELMYDVLDESLRRAELNH-NVTYAILFECVHTVYSIYPKSELLEKAAKCIGKF 344

  Fly   350 LSNRETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNA 414
            :.:.:.||:||.|:::.::...:   ..:....::.|:......|..:::..::|||.:.:..|.
Human   345 VLSPKINLKYLGLKALTYVIQQD---PTLALQHQMTIIECLDHPDPIIKRETLELLYRITNAQNI 406

  Fly   415 EEIVQEMLNYLETADYSIREEMVL-----KVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVW 474
            ..|||:||.||    :..:||.|:     |:|.||||||.|..|::..:..:..:.||.:..::.
Human   407 TVIVQKMLEYL----HQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIP 467

  Fly   475 YRVIQIV------------INREEVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDS 527
            ...::::            :....||.|......|.:..|   :..::|..::|||:..|:..::
Human   468 NNFLRLLAEGFDDETEDQQLRLYAVQSYLTLLDMENVFYP---QRFLQVMSWVLGEYSYLLDKET 529

  Fly   528 RSAPLVQ-FKLLHSKYHLCSPMTRALLLSTYIKFIN----------LFPEIRTNIQDVFRQHS-- 579
            ....:.: :|||.:  ...|..|:|.|::...|..:          |..|...::....|||:
Human   530 PEEVIAKLYKLLMN--DSVSSETKAWLIAAVTKLTSQAHSSNTVERLIHEFTISLDTCMRQHAFE 592

  Fly   580 ------NL----------RS-----ADAEL---------------------QQRASEYLQ----- 597
                  |:          ||     .||.|                     .||..|.|.
Human   593 LKHLHENVELMKSLLPVDRSCEDLVVDASLSFLDGFVAEGLSQGAAPYKPPHQRQEEKLSQEKVL 657

  Fly   598 ------LSIVAS--------------TDVLATVLEEMPSFPERESSILAVLKK--KKPGRVPENE 640
                  ||..:|              :||.....|  ....|..|..|..:||  .|.|.:|:
Human   658 NFEPYGLSFSSSGFTGRQSPAGISLGSDVSGNSAE--TGLKETNSLKLEGIKKLWGKEGYLPK-- 718

  Fly   641 IRESKS-------PAP-----------LTSAAQNNALVNNSHSKLNNSNANTDLLGLSTPPSNNI 687
             :|||:       |.|           :|...|:..|..:...|.....|::..:||.:..:.|:
Human   719 -KESKTGDESGALPVPQESIMENVDQAITKKDQSQVLTQSKEEKEKQLLASSLFVGLGSESTINL 782

  Fly   688 --------------------GSGS---------NSNSTLIDV-LGDMYGSNSNNNSSAVYNTKKF 722
                                .||.         :|.|:|.:| ..|.|.||:.:::.. ...|||
Human   783 LGKADTVSHKFRRKSKVKEAKSGETTSTHNMTCSSFSSLSNVAYEDDYYSNTLHDTGD-KELKKF 846

  Fly   723 LFKNNGVLFENEML-QIGVKSEFRQ-NLGRLGLFYGNKTQVPLTNFNPVLQWSAEDALKLNVQMK 785
            ...:.  |.::|.| ::.:..:|.. :|....||..|..::    |:|....:|..|.:.::...
Human   847 SLTSE--LLDSESLTELPLVEKFSYCSLSTPSLFANNNMEI----FHPPQSTAASVAKESSLASS 905

  Fly   786 VVEPTLE-------------------------------------AGAQIQ----QLLTAE----- 804
            .:|.|.|                                     :|.:::    ::..||
Human   906 FLEETTEYIHSNAMEVCNNETISVSSYKIWKDDCLLMVWSVTNKSGLELKSADLEIFPAENFKVT 970

  Fly   805 -----CIEDYADAPTIEI----SFRY------------------------NGTQQKFSIKLPLSV 836
                 |:      |.:|.    ||:|                        :..|.:||:.  ||:
Human   971 EQPGCCL------PVMEAESTKSFQYSVQIEKPFTEGNLTGFISYHMMDTHSAQLEFSVN--LSL 1027

  Fly   837 NKFFEPTEMNAESFFARWKNLSGEQQRSQKV--FKAAQPLDLPGARNKLMGFGMQLLDQVDPNPD 899
            ..|..|.:::::.|...|.:.:.:.:::.|:  .:||.|..|...:.||.   :.:::.:. |..
Human  1028 LDFIRPLKISSDDFGKLWLSFANDVKQNVKMSESQAALPSALKTLQQKLR---LHIIEIIG-NEG 1088

  Fly   900 NMVCAGIIHTQSQQVGCLMRLEPNKQAQMFRLTVRASKETVTREICDLLTD 950
            .:.|..:     ..:.||:....:  |.:..|..|:|        |..|.|
Human  1089 LLACQLL-----PSIPCLLHCRVH--ADVLALWFRSS--------CSTLPD 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	150/651 (23%)
		Alpha_adaptinC2	730..839	CDD:197886	29/189 (15%)
		Alpha_adaptin_C	839..947	CDD:280460	20/109 (18%)
AP4E1	NP_031373.2	Adaptin_N	52..596	CDD:331138	140/583 (24%)
		Interaction with TEPSIN. /evidence=ECO:0000269|PubMed:26542808	727..1137		74/432 (17%)
		AP4E_app_platf	1033..1132	CDD:317244	21/111 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810