DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-2alpha and apg-1

DIOPT Version :9

Sequence 1:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_740937.1	Gene:	apg-1 / 173304	WormBaseID:	WBGene00000158	Length:	829	Species:	Caenorhabditis elegans

Alignment Length:	834	Identity:	226/834 - (27%)
Similarity:	399/834 - (47%)	Gaps:	116/834 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 INKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYSEKQIGYLF 108
            :::|.||||..|:.|   |...|.:.:.|||:|.:||:...||.||.:.|::..::::|:||||.
Worm    49 VDRESANIRESFRDD---DSPWKCRNIAKLLYIHMLGYPAHFGQMECMKLVAHPRFTDKRIGYLG 110

  Fly   109 ISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKLLVSGDTMD 173
            ..:|::..|::..|:..|:||||.........|||..:.:|.|.:|....:||:.|::...:.
Worm   111 AMLLLDERSEVHMLVTNSLKNDLTCSTQFVSGLALCTLGSICSAEMCRDLANEVEKIIKQNNA-- 173

  Fly   174 VVKQSAALCLLRLFRSSPDI----IPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNPD--- 231
            .:|:.||||..|:.|..|::    ||    .:|  .||.:::.||:..||:|:..:.:::||
Worm   174 YLKKKAALCAFRIVRKVPELMEVFIP----CTR--SLLGEKNHGVLMGATTLVTEMCEKSPDVLN 232

  Fly   232 EYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNP----VTEEAGVRARL 292
            .:|..|...|..|..::.:.|:...|.|  .:..|:|.||:||||:....    ||||      :
Worm   233 HFKKLVPNLVRILKNLLMSGYSPEHDVT--GISDPFLQVKILRLLRVLGKDDVRVTEE------M 289

  Fly   293 NETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNL 357
            |:.|..:....:..        .|..||:|:|.:..|:...||..|.:.|.|.||:||.|.:.|:
Worm   290 NDILAQVATNTETA--------KNVGNAILYETVLTIMEIKSESGLRILAVNILGRFLLNTDKNI 346

  Fly   358 RYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEML 422
            ||:||.::  |.|....::.|::|:.||:..:| :.|:|:|:.|::|.:|:.:|.|...:.:|:|
Worm   347 RYVALNTL--LKTVHVDYQAVQRHRNVVVECLK-DPDISIRKRAMELCFALMNRTNIAIMTKEVL 408

  Fly   423 NYLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEV 487
            .:|||||...:.|...::.|..|:|:.::.|::|.::.::|:||.||.:||...:||::...|::
Worm   409 IFLETADAEFKSECASRMYIATERYSPNHEWHLDTMITVLRLAGKYVPDEVVSCMIQMISANEQL 473

  Fly   488 QGYAAKTVFEALQAPACH-ENMVKVGGYILGEFGNLI--AGDSRSAPL-------VQFKLLHSKY 542
            |.||...::.|.|..|.: :.:::|..:.:||||:|:  ..|..|.|:       |...:|.|.
Worm   474 QSYAVSQLYHAAQKDAINAQPLLQVAFWTIGEFGDLLLQPTDVDSTPISENDVVGVFESVLPSA- 537

  Fly   543 HLCSPMTRALLLSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSIVAST-DV 606
             |.|..|:...::...|....|......|..:.|.  |......|||||:.|:   :::.:. |:
Worm   538 -LTSLWTKCYGVTALAKLGTRFQSTGDRIGALVRM--NQAHIQLELQQRSVEF---NVILNLGDL 596

  Fly   607 LATVLEEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPAPLTSAAQNNALVNNSHSKLNNSN 671
            ...:||.||......      |....|..:.|....||.:|.........:..:....|...:::
Worm   597 RDGLLERMPVITHNS------LNAAAPSMIDEEVSAESGAPVVTNGDLLGDLNLGGGGSTNPSND 655

  Fly   672 ANTDLLGLSTPPSNNIGSGS------------NSNSTLIDVLGDMYGSNSNNN---------SSA 715
            .::||||:      .:|||:            .|||.::|:.||...||:...         ...
Worm   656 YSSDLLGV------GVGSGAASAQAPPPPPPPTSNSNILDIFGDTPSSNAAGGFDFGMAAPAKEP 714

  Fly   716 VYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFN--PVLQWSAEDAL 778
            .|  :..:..|.|.:    .:|:.|...::....||.:...|.|...|:|:|  ..:..:.|.||
Worm   715 TY--QPVIAINKGGI----EVQLQVIETWKNEKARLRMTAYNYTPRTLSNYNFFAAVTKTFEIAL 773

  Fly   779 KLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADAPT------IEISFRYNGTQQ 826
            :     ....|.::......|.:|..     ..||.      .:||:..:||:|
Worm   774 E-----PASSPNIDPNEHTTQFMTIT-----RKAPNTTARMRTKISYIVDGTEQ 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	174/574 (30%)
		Alpha_adaptinC2	730..839	CDD:197886	22/105 (21%)
		Alpha_adaptin_C	839..947	CDD:280460
apg-1	NP_740937.1	Adaptin_N	45..595	CDD:279882	174/582 (30%)
apg-1	NP_740937.1	Alpha_adaptinC2	721..827	CDD:197886	24/111 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53727
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820