Protein Alignment AP-2alpha and apg-1

DIOPT Version :10

• Sequence 1: NP_995607.1
• Gene: AP-2alpha / 33211
• FlyBaseID: FBgn0264855
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: NP_740937.1
• Gene: apg-1 / 173304
• WormBaseID: WBGene00000158
• Length: 829
• Species: Caenorhabditis elegans
• Alignment Length: 834
• Identity: 226/834 - (27%)
• Similarity: 399/834 - (47%)
• Gaps: 116/834 - (13%)

  Fly    44 INKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYSEKQIGYLF 108
            :::|.||||..|:.|   |...|.:.:.|||:|.:||:...||.||.:.|::..::::|:||||.
 Worm    49 VDRESANIRESFRDD---DSPWKCRNIAKLLYIHMLGYPAHFGQMECMKLVAHPRFTDKRIGYLG 110

  Fly   109 ISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKLLVSGDTMD 173
            ..:|::..|::..|:..|:||||.........|||..:.:|.|.:|....:||:.|::...:.
 Worm   111 AMLLLDERSEVHMLVTNSLKNDLTCSTQFVSGLALCTLGSICSAEMCRDLANEVEKIIKQNNA-- 173

  Fly   174 VVKQSAALCLLRLFRSSPDI----IPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNPD--- 231
            .:|:.||||..|:.|..|::    ||    .:|  .||.:::.||:..||:|:..:.:::||
 Worm   174 YLKKKAALCAFRIVRKVPELMEVFIP----CTR--SLLGEKNHGVLMGATTLVTEMCEKSPDVLN 232

  Fly   232 EYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNP----VTEEAGVRARL 292
            .:|..|...|..|..::.:.|:...|.|  .:..|:|.||:||||:....    ||||      :
 Worm   233 HFKKLVPNLVRILKNLLMSGYSPEHDVT--GISDPFLQVKILRLLRVLGKDDVRVTEE------M 289

  Fly   293 NETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNL 357
            |:.|..:....:..        .|..||:|:|.:..|:...||..|.:.|.|.||:||.|.:.|:
 Worm   290 NDILAQVATNTETA--------KNVGNAILYETVLTIMEIKSESGLRILAVNILGRFLLNTDKNI 346

  Fly   358 RYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEML 422
            ||:||.::  |.|....::.|::|:.||:..:| :.|:|:|:.|::|.:|:.:|.|...:.:|:|
 Worm   347 RYVALNTL--LKTVHVDYQAVQRHRNVVVECLK-DPDISIRKRAMELCFALMNRTNIAIMTKEVL 408

  Fly   423 NYLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEV 487
            .:|||||...:.|...::.|..|:|:.::.|::|.::.::|:||.||.:||...:||::...|::
 Worm   409 IFLETADAEFKSECASRMYIATERYSPNHEWHLDTMITVLRLAGKYVPDEVVSCMIQMISANEQL 473

  Fly   488 QGYAAKTVFEALQAPACH-ENMVKVGGYILGEFGNLI--AGDSRSAPL-------VQFKLLHSKY 542
            |.||...::.|.|..|.: :.:::|..:.:||||:|:  ..|..|.|:       |...:|.|.
 Worm   474 QSYAVSQLYHAAQKDAINAQPLLQVAFWTIGEFGDLLLQPTDVDSTPISENDVVGVFESVLPSA- 537

  Fly   543 HLCSPMTRALLLSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSIVAST-DV 606
             |.|..|:...::...|....|......|..:.|.  |......|||||:.|:   :::.:. |:
 Worm   538 -LTSLWTKCYGVTALAKLGTRFQSTGDRIGALVRM--NQAHIQLELQQRSVEF---NVILNLGDL 596

  Fly   607 LATVLEEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPAPLTSAAQNNALVNNSHSKLNNSN 671
            ...:||.||......      |....|..:.|....||.:|.........:..:....|...:::
 Worm   597 RDGLLERMPVITHNS------LNAAAPSMIDEEVSAESGAPVVTNGDLLGDLNLGGGGSTNPSND 655

  Fly   672 ANTDLLGLSTPPSNNIGSGS------------NSNSTLIDVLGDMYGSNSNNN---------SSA 715
            .::||||:      .:|||:            .|||.::|:.||...||:...         ...
 Worm   656 YSSDLLGV------GVGSGAASAQAPPPPPPPTSNSNILDIFGDTPSSNAAGGFDFGMAAPAKEP 714

  Fly   716 VYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFN--PVLQWSAEDAL 778
            .|  :..:..|.|.:    .:|:.|...::....||.:...|.|...|:|:|  ..:..:.|.||
 Worm   715 TY--QPVIAINKGGI----EVQLQVIETWKNEKARLRMTAYNYTPRTLSNYNFFAAVTKTFEIAL 773

  Fly   779 KLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADAPT------IEISFRYNGTQQ 826
            :     ....|.::......|.:|..     ..||.      .:||:..:||:|
 Worm   774 E-----PASSPNIDPNEHTTQFMTIT-----RKAPNTTARMRTKISYIVDGTEQ 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..603	CDD:396262	174/579 (30%)
		Alpha_adaptinC2	730..839	CDD:197886	22/105 (21%)
		Alpha_adaptin_C	839..947	CDD:426707
apg-1	NP_740937.1	Adaptin_N	45..595	CDD:396262	174/582 (30%)
		Alpha_adaptinC2	721..827	CDD:197886	24/111 (22%)