DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP-2alpha and AP1G1

DIOPT Version :10

Sequence 1:NP_995607.1 Gene:AP-2alpha / 33211 FlyBaseID:FBgn0264855 Length:952 Species:Drosophila melanogaster
Sequence 2:NP_001025178.1 Gene:AP1G1 / 164 HGNCID:555 Length:825 Species:Homo sapiens


Alignment Length:850 Identity:213/850 - (25%)
Similarity:409/850 - (48%) Gaps:110/850 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 KSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKY 99
            :::..|.:.|.||.|.|||.|:.:   |...:.:.|.|||::.:||:...||.:|.:.|::|.|:
Human    18 RTQAEEREMIQKECAAIRSSFREE---DNTYRCRNVAKLLYMHMLGYPAHFGQLECLKLIASQKF 79

  Fly   100 SEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPK 164
            ::|:||||...:|::...|:..|:...|||||.........|||..:..:||.:|....:.|:.|
Human    80 TDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGEVEK 144

  Fly   165 LLVSGDTMDVVKQSAALCLLRLFRSSPDI----IPGGEWTSRIIHLLNDQHMGVVTAATSLIDAL 225
            ||.:.::  .:::.||||.:.:.|..|::    :|..:      :|||:::.||:..:..|:..:
Human   145 LLKTSNS--YLRKKAALCAVHVIRKVPELMEMFLPATK------NLLNEKNHGVLHTSVVLLTEM 201

  Fly   226 VKRNPD------EYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTE 284
            .:|:||      :.:..|...|..|..::.:.|:...|.:  .:..|:|.|::||||:......:
Human   202 CERSPDMLAHFRKNEKLVPQLVRILKNLIMSGYSPEHDVS--GISDPFLQVRILRLLRILGRNDD 264

  Fly   285 EAGVRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQF 349
            ::      :|.:..||.:.....::.|    |..||:|:|.:..|:...||..|.|.|.|.||:|
Human   265 DS------SEAMNDILAQVATNTETSK----NVGNAILYETVLTIMDIKSESGLRVLAINILGRF 319

  Fly   350 LSNRETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNA 414
            |.|.:.|:||:||.|:  |.|.:..|..|::|:..::..:| :.|||:::.|::|.:|:.:..|.
Human   320 LLNNDKNIRYVALTSL--LKTVQTDHNAVQRHRSTIVDCLK-DLDVSIKRRAMELSFALVNGNNI 381

  Fly   415 EEIVQEMLNYLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQ 479
            ..:::|:|.:|::.:...:.:....:.:.|||||....|::|.|:.::..||.||.::....:||
Human   382 RGMMKELLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQ 446

  Fly   480 IVINREEVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGN-LIAGDSRSAPLVQ------FKL 537
            ::.|..|:..|..:.:::|:......:.:|:|..:.:||:|: |::|.......:|      ..:
Human   447 LITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCIGEYGDLLVSGQCEEEEPIQVTEDEVLDI 511

  Fly   538 LHSKY--HLCSPMTRALLLSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSI 600
            |.|..  ::.:.:||...|:..:|....|......|:.|...:.:  |.|.||||||.||..| .
Human   512 LESVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRIKKVVSIYGS--SIDVELQQRAVEYNAL-F 573

  Fly   601 VASTDVLATVLEEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPAPLTS---------AAQN 656
            .....:.:.:||.||        ::..:....|..:.:.  .....||||.:         .:|.
Human   574 KKYDHMRSALLERMP--------VMEKVTTNGPTEIVQT--NGETEPAPLETKPPPSGPQPTSQA 628

  Fly   657 NALVNNSHSKLNNSNANTDLLGLS--TP--PSNNIGSGSNSNSTLIDVLGDMYGSNSNNNSSAVY 717
            |.|:              ||||.:  ||  |:......|::...|:|:|||:..:.:...:.|..
Human   629 NDLL--------------DLLGGNDITPVIPTAPTSKPSSAGGELLDLLGDINLTGAPAAAPAPA 679

  Fly   718 NTKK-----FLFK--NNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLT----NFNP--- 768
            :..:     ||..  ::..||.:  :..|:.|        :..:..|..::..|    |.||   
Human   680 SVPQISQPPFLLDGLSSQPLFND--IAAGIPS--------ITAYSKNGLKIEFTFERSNTNPSVT 734

  Fly   769 VLQWSAEDALKLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADAPTI-EISFRYNGTQQKFSIKL 832
            |:...|.::.:|::...|.:..:....|:|.|..:..|....:..|| ::....|..:|:..:::
Human   735 VITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSIVPAFNTGTITQVIKVLNPQKQQLRMRI 799

  Fly   833 PLSVN 837
            .|:.|
Human   800 KLTYN 804

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-2alphaNP_995607.1 Adaptin_N 40..603 CDD:396262 162/581 (28%)
Alpha_adaptinC2 730..839 CDD:197886 22/115 (19%)
Alpha_adaptin_C 839..947 CDD:426707
AP1G1NP_001025178.1 Adaptin_N 23..577 CDD:396262 162/582 (28%)
HEAT repeat 142..163 CDD:293787 7/22 (32%)
HEAT repeat 175..203 CDD:293787 7/33 (21%)
HEAT repeat 246..276 CDD:293787 10/35 (29%)
HEAT repeat 287..319 CDD:293787 13/31 (42%)
Herpes_BLLF1 <593..>654 CDD:282904 15/76 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 600..631 6/32 (19%)
Alpha_adaptinC2 712..820 CDD:197886 18/92 (20%)
Blue background indicates that the domain is not in the aligned region.

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