DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AP-2alpha and Ap3d1

DIOPT Version :9

Sequence 1:NP_995607.1 Gene:AP-2alpha / 33211 FlyBaseID:FBgn0264855 Length:952 Species:Drosophila melanogaster
Sequence 2:NP_031486.1 Gene:Ap3d1 / 11776 MGIID:107734 Length:1199 Species:Mus musculus


Alignment Length:925 Identity:190/925 - (20%)
Similarity:374/925 - (40%) Gaps:195/925 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 KEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYSE 101
            ||.|.|.|::.:..|:.:.|.|...   .|...||||.::.:||:||.:.....:.::|::|::.
Mouse    29 KEDEAKYISQCIDEIKQELKQDNIA---VKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTF 90

  Fly   102 KQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPKLL 166
            |::|||..|...:..:|:|.|....|:.||.|.:.....:||..::...:.|:|...:|:|..|:
Mouse    91 KRVGYLAASQCFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLM 155

  Fly   167 VSGDTMDVVKQSAALCLLRLFRSSPDII-PGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKRNP 230
              ..|...:::.|.|.:.::|...|:.: |.   ..|:...|.|...||.:||.::|..|.:|||
Mouse   156 --SHTKPYIRKKAVLIMYKVFLKYPESLRPA---FPRLKEKLEDPDPGVQSAAVNVICELARRNP 215

  Fly   231 DEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLNET 295
            ..|.....|    ..:::|:|..:            |:.:|:::|.....|:....|  .:|.|.
Mouse   216 KNYLSLAPL----FFKLMTSSTNN------------WVLIKIIKLFGALTPLEPRLG--KKLIEP 262

  Fly   296 LETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIH-----SDSEPN--LLVRACNQ-LGQFLSN 352
            |..::             ||.:..::|:|.:|.:|.     |...||  ..::.|.| |...:.:
Mouse   263 LTNLI-------------HSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIED 314

  Fly   353 RETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEI 417
            .:.||:||.|.:|..:..:.  .:.|:.|:::::..:. :||.|:|..|:||||.|..:.|..||
Mouse   315 SDQNLKYLGLLAMSKILKTH--PKSVQSHKDLILQCLD-DKDESIRLRALDLLYGMVSKKNLMEI 376

  Fly   418 VQEMLNYLETAD-YSIREEMVLKVAILAE----KYATDYTWYVDVILNLIRIAGDYVSEEVWYRV 477
            |::::.:::.|: .:.|:|::.|:..:..    ::.|::.||:.:::.|.|:.|......:..::
Mouse   377 VKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQHITNFEWYISILVELTRLEGTRHGHLIAAQM 441

  Fly   478 IQIVINREEVQGYAAKTVFEALQ-----APACHEN----MVKVGGYILGEFGNLIAGDSRSAPLV 533
            :.:.|..:.::.:|...:...|.     |.:...|    ::....:|.|||...:.|..::..  
Mouse   442 LDVAIRVKAIRKFAVSQMSSLLDSAHLVASSTQRNGICEVLYAAAWICGEFSEHLQGPQQTLE-- 504

  Fly   534 QFKLLHSKYHLCSPMTRALLLSTYIKFINLFPEIRTNIQD-----------VFRQHSNLRSADAE 587
              .:|..|........:|:.:...:|......:.:....|           |.|....::|||.|
Mouse   505 --AMLRPKVTTLPGHIQAVYVQNVVKLYASILQQKEQAADTEAAQEVTQLLVERLPQFVQSADLE 567

  Fly   588 LQQRASEYLQLSIVASTDVL----ATVLEEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPA 648
            :|:|||..|||  |.....|    ..|.||:.:....|.:.:|...:||               .
Mouse   568 VQERASCILQL--VKHVQKLQAKGVPVAEEVSALFAGELNPVAPKAQKK---------------V 615

  Fly   649 PLTSAAQNNALVNNSHSKLNNSNANTDLLGLSTPPSNNIGSGSNSNSTLIDVLGDMYGSNSNNNS 713
            |:......:|.:|.                   |||::                    .:.:...
Mouse   616 PVPEGLDLDAWINE-------------------PPSDS--------------------ESEDEKP 641

  Fly   714 SAVYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFN--------PVL 770
            .|:::.::..........|:|. ::..:.|.|:.......||...:..|...:.        ||:
Mouse   642 KAIFHEEEPRHTRRRQPEEDEE-ELARRREARKQEQANNPFYIKSSPSPQKRYQDAPGVEHIPVV 705

  Fly   771 QWSAEDALKLNVQMKVVEPTL----------------------------EAGAQIQQLLTAECIE 807
            |      :.|:|.:||  |.:                            |.|.:....|..|..|
Mouse   706 Q------IDLSVPLKV--PGMPMSDQYVKLEEQRRHRQRLEKDKKRKKKEKGKRRHSSLPTESDE 762

  Fly   808 DYADAPTIEISFRYNGTQQKFSIKLP-----LSVNKFFEPTEMNAESFFARWKNLSGEQQRSQKV 867
            |.|.|..::|.     |::.....||     ...|..:...:::.:...|..:.|..::.|:.:.
Mouse   763 DIAPAQRVDII-----TEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPVQKHRNAEA 822

  Fly   868 FKAAQPLDLPGARNK 882
            .|:.:...:.|...|
Mouse   823 VKSPEKEGVLGVEKK 837

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-2alphaNP_995607.1 Adaptin_N 40..598 CDD:279882 136/591 (23%)
Alpha_adaptinC2 730..839 CDD:197886 28/149 (19%)
Alpha_adaptin_C 839..947 CDD:280460 6/44 (14%)
Ap3d1NP_031486.1 Adaptin_N 32..581 CDD:279882 139/596 (23%)
HEAT 1 34..71 12/39 (31%)
HEAT 2 142..179 9/38 (24%)
HEAT repeat 151..172 CDD:293787 5/22 (23%)
Cnd1 155..265 CDD:289487 30/132 (23%)
HEAT 3 180..216 12/38 (32%)
HEAT repeat 184..212 CDD:293787 9/30 (30%)
HEAT 4 218..254 8/51 (16%)
HEAT repeat 220..262 CDD:293787 9/59 (15%)
HEAT 5 257..296 10/51 (20%)
HEAT repeat 271..292 CDD:293787 4/20 (20%)
HEAT 6 298..336 9/39 (23%)
HEAT repeat 301..330 CDD:293787 9/28 (32%)
HEAT repeat 335..364 CDD:293787 8/29 (28%)
HEAT 7 337..373 12/36 (33%)
HEAT 8 375..409 7/33 (21%)
HEAT 9 521..558 4/36 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..695 13/111 (12%)
BLVR 661..803 CDD:283923 27/155 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 724..963 19/119 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG4354
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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