DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-2alpha and Ap2a2

DIOPT Version :9

Sequence 1:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001343997.1	Gene:	Ap2a2 / 11772	MGIID:	101920	Length:	939	Species:	Mus musculus

Alignment Length:	941	Identity:	648/941 - (68%)
Similarity:	759/941 - (80%)	Gaps:	46/941 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CKSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNK 98
            |||||||:||||||||||||||||||.||||.||||||||||||||||||||||||||||||||:
Mouse    23 CKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNR 87

  Fly    99 YSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIP 163
            |:||||||||||||||:||:|||||..:|||||.||||..:.|||.||||:|||:|||:|:.|||
Mouse    88 YTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIANVGSREMAEAFAGEIP 152

  Fly   164 KLLVSGDTMDVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKR 228
            |:||:|||||.||||||||||||:|:|||::|.|:||||::|||||||:||||||||||..|.::
Mouse   153 KILVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQK 217

  Fly   229 NPDEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLN 293
            ||:|:|..|:|||||||||||::.|||||||||||||||||||||||||.| |..|:..||.||.
Mouse   218 NPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCY-PPPEDPAVRGRLT 281

  Fly   294 ETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNLR 358
            |.|||||||||||||||||||||||||||||||:||||.||||||||||||||||||.:||||||
Mouse   282 ECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLR 346

  Fly   359 YLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEMLN 423
            ||||||||.||:||||||.||.|.|.||.::|.|:||||||.|||||||||||.||::||.|||:
Mouse   347 YLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAQQIVAEMLS 411

  Fly   424 YLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEVQ 488
            ||||||||||||:||||||||||||.|||||||.|||||||||||||||||||||||||||::||
Mouse   412 YLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQ 476

  Fly   489 GYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDSRSAPLVQFKLLHSKYHLCSPMTRALL 553
            |||||||||||||||||||:||||||||||||||||||.||:||:||.|||||:||||..|||||
Mouse   477 GYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFNLLHSKFHLCSVPTRALL 541

  Fly   554 LSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSIVASTDVLATVLEEMPSFP 618
            |||||||:|||||::..||||.|..|.|::||.||||||.|||:||.|||||:|||||||||.||
Mouse   542 LSTYIKFVNLFPEVKATIQDVLRSDSQLKNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFP 606

  Fly   619 ERESSILAVLKKKK-PGRVPENEIRESK---------SPAPL---TSAAQNNALVNNSHSKLNNS 670
            ||||||||.||||| |..|  .::.|:|         .|.|:   ||||             :..
Mouse   607 ERESSILAKLKKKKGPSTV--TDLEETKRERSIDVNGGPEPVPASTSAA-------------STP 656

  Fly   671 NANTDLLGL-STPPSNNIGSGSNSNSTLIDVLGDMYGSNSNNNSSAVY--------NTKKFLFKN 726
            :.:.||||| :.||:......|:....|:||..|        ::|||.        |..:|:.||
Mouse   657 SPSADLLGLGAVPPAPTGPPPSSGGGLLVDVFSD--------SASAVAPLAPGSEDNFARFVCKN 713

  Fly   727 NGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFNPVLQWSAEDALKLNVQMKVVEPTL 791
            |||||||::||||:||||||||||:.:||||||.....||.|.|..:.:....||:|.|.|:||:
Mouse   714 NGVLFENQLLQIGLKSEFRQNLGRMFIFYGNKTSTQFLNFTPTLICADDLQTNLNLQTKPVDPTV 778

  Fly   792 EAGAQIQQLLTAECIEDYADAPTIEISFRYNGTQQKFSIKLPLSVNKFFEPTEMNAESFFARWKN 856
            :.|||:||::..|||.|:.:||.:.|.|||.||.|..|:|||:::||||:||||.::.||.|||.
Mouse   779 DGGAQVQQVVNIECISDFTEAPVLNIQFRYGGTFQNVSVKLPITLNKFFQPTEMASQDFFQRWKQ 843

  Fly   857 LSGEQQRSQKVFKAAQPLDLPGARNKLMGFGMQLLDQVDPNPDNMVCAGIIHTQSQQVGCLMRLE 921
            ||..||..|.:|||..|:|....:.|::|||..||::|||||.|.|.||||||::.|:|||:|||
Mouse   844 LSNPQQEVQNIFKAKHPMDTEITKAKIIGFGSALLEEVDPNPANFVGAGIIHTKTTQIGCLLRLE 908

  Fly   922 PNKQAQMFRLTVRASKETVTREICDLLTDQF 952
            ||.||||:|||:|.||:||::.:|:||::||
Mouse   909 PNLQAQMYRLTLRTSKDTVSQRLCELLSEQF 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	454/557 (82%)
		Alpha_adaptinC2	730..839	CDD:197886	58/108 (54%)
		Alpha_adaptin_C	839..947	CDD:280460	62/107 (58%)
Ap2a2	NP_001343997.1	Lipid-binding	5..80		53/56 (95%)
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250\|UniProtKB:P18484	11..12
		Adaptin_N	29..591	CDD:396262	457/562 (81%)
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250\|UniProtKB:P18484	57..61		3/3 (100%)
		HEAT repeat	332..355	CDD:293787	20/22 (91%)
		HEAT repeat	369..398	CDD:293787	20/28 (71%)
		HEAT repeat	408..434	CDD:293787	23/25 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..682		23/80 (29%)
		Alpha_adaptinC2	717..820	CDD:197886	55/102 (54%)
		Alpha_adaptin_C	826..934	CDD:367023	62/107 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845814
Domainoid	1	1.000	903	1.000	Domainoid score	I49
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5335
Inparanoid	1	1.050	1292	1.000	Inparanoid score	I161
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53727
OrthoDB	1	1.010	-	-		D751651at2759
OrthoFinder	1	1.000	-	-		FOG0002465
OrthoInspector	1	1.000	-	-		otm44140
orthoMCL	1	0.900	-	-		OOG6_101447
Panther	1	1.100	-	-	LDO	PTHR22780
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R61
SonicParanoid	1	1.000	-	-		X1882
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800