Protein Alignment AP-2alpha and Ap1g2

DIOPT Version :10

• Sequence 1: NP_995607.1
• Gene: AP-2alpha / 33211
• FlyBaseID: FBgn0264855
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: NP_031481.2
• Gene: Ap1g2 / 11766
• MGIID: 1328307
• Length: 791
• Species: Mus musculus
• Alignment Length: 856
• Identity: 224/856 - (26%)
• Similarity: 386/856 - (45%)
• Gaps: 114/856 - (13%)

  Fly    13 IDQSRGGKESEASADESLLFYCKSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIF 77
            |::.||.|             .:::|.||  |.||.|.||:.|:..   |..|:.:.:.|||::.
Mouse    12 IEEIRGAK-------------TQAQEREV--IQKECAQIRASFRDG---DPLQRHRQLAKLLYVH 58

  Fly    78 LLGHDIDFGHMEAVNLLSSNKYSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLA 142
            :||:...||.||.:.|::|.::::|::|||...:|::...|...||..||||||...|.....||
Mouse    59 MLGYPAHFGQMECLKLIASPRFTDKRVGYLGAMLLLDERHDSHLLITNSIKNDLSQGNQPVQGLA 123

  Fly   143 LQCIANIGSRDMAESFSNEIPKLLVSGDTMDVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIHLL 207
            |..::.:||.:|....:.|:.|||:  .....|::.|.|..:.:.|..|::  .|.:......||
Mouse   124 LCTLSTMGSAEMCRDLAPEVEKLLL--QPSPYVRKKAILTAVHMIRKDPEL--SGIFLPPCTKLL 184

  Fly   208 NDQHMGVVTAATSLIDALVKRNP---DEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLS 269
            .::|.|:.....:||..|.:|||   ..::..|...|..|..:||..|:  .:::...|..|:|.
Mouse   185 RERHHGIQLGTVTLITELCERNPAALRHFRKVVPQLVQILRTLVTTGYS--TEHSISGVSDPFLQ 247

  Fly   270 VKLLRLLQNYNPVTEEAGVRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDS 334
            |::||||:......||:      :||:..:|.:......:.:    ||.||||.|.:..|:...|
Mouse   248 VQILRLLRILGRNHEES------SETMNDLLAQVATNTDTSR----NAGNAVLLETVLTIMAIHS 302

  Fly   335 EPNLLVRACNQLGQFLSNRETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQ 399
            ...|.|.|.|.||:||.|.:.|:||:||.|:..|..|:  |..|::|:..|:..:: |.|.|:.:
Mouse   303 AAGLRVLAVNILGRFLLNNDKNIRYVALTSLLQLVQSD--HSAVQRHRSTVVECLQ-ETDASLSR 364

  Fly   400 MAVDLLYAMCDRGNAEEIVQEMLNYLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRI 464
            .|::|..|:.:..|...::||:..:||:....:|.:....:.:.||::|....|::|.||:::..
Mouse   365 RALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPSKRWHIDTILHVLTT 429

  Fly   465 AGDYVSEEVWYRVIQIVINREEVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGN-LIAGDSR 528
            ||.:|.::....:.|::...||:..|:.:.::.||......:.:|:|..:.:||:|: |:.|:..
Mouse   430 AGAHVRDDAVANLTQLIGEAEELHTYSVRRLYSALAEDISQQPLVQVAAWCIGEYGDLLLEGNCE 494

  Fly   529 SAPLVQF----------KLLHSKYHLCSPMTRALLLSTYIKFINLFPEIRTNIQDVFRQHSNLRS 583
            .....|.          |:|.|  |:..|.||...::..:|...........|:.|...:.:  .
Mouse   495 ETEPFQVEEEDVLALLEKVLQS--HMSLPATRGYAITALMKLSTRLRGDNNRIRQVVSIYGS--C 555

  Fly   584 ADAELQQRASEYLQLSIVASTDVLATVLEEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPA 648
            .|.||||||.||..| ......:.|.:||:||.....:..:      |:.|:..:.|.:..:..|
Mouse   556 VDLELQQRAVEYNTL-FQKYDHMRAAILEKMPLVERGDPHV------KEGGKEKQTEAQPLEVTA 613

  Fly   649 PLTSAAQNNALVNNSHSKLNNSNANTDLLGLSTPPSNNIGSG---------SNSNSTLIDVLGDM 704
            |..:..|...|:              |||.|....|..:.||         .:....||.:| |:
Mouse   614 PAPTEPQATKLL--------------DLLDLLGDTSEPLSSGHAQHLPPQTPSPGEALIHLL-DL 663

  Fly   705 YGSNSNNNSSAVYNTKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFNPV 769
              ..:....:.:.:.:         :||.|.||:.:  .|.:.|....|..     |..|..|.
Mouse   664 --PCTPPPPAPIPSVR---------VFEREGLQLDL--SFMRPLETPALLL-----VTATTTNS- 709

  Fly   770 LQWSAEDALKLNVQMKVVEPTLEAGAQIQ-QLLTAECIEDYADAPTIEISFRYNGTQQKFSIKLP 833
               |.||     |...|.:..:....|:| |..:...|......|..::....|..|....:||.
Mouse   710 ---SKED-----VTHFVCQAAVPKSFQLQLQAPSGNTIPAQGGLPITQVFRILNPNQAPLRLKLR 766

  Fly   834 LSVNKFFEPTE 844
            |:.|...:|.:
Mouse   767 LTYNHSGQPVQ 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..603	CDD:396262	168/576 (29%)
		Alpha_adaptinC2	730..839	CDD:197886	27/109 (25%)
		Alpha_adaptin_C	839..947	CDD:426707	1/6 (17%)
Ap1g2	NP_031481.2	Adaptin_N	24..575	CDD:396262	169/579 (29%)
		Alpha_adaptinC2	678..786	CDD:197886	28/116 (24%)