DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-2alpha and Ap1g1

DIOPT Version :9

Sequence 1:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_033807.2	Gene:	Ap1g1 / 11765	MGIID:	101919	Length:	825	Species:	Mus musculus

Alignment Length:	850	Identity:	213/850 - (25%)
Similarity:	410/850 - (48%)	Gaps:	110/850 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKY 99
            :::..|.:.|.||.|.|||.|:.:   |...:.:.|.|||::.:||:...||.:|.:.|::|.|:
Mouse    18 RTQAEEREMIQKECAAIRSSFREE---DNTYRCRNVAKLLYMHMLGYPAHFGQLECLKLIASQKF 79

  Fly   100 SEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIPK 164
            ::|:||||...:|::...|:..|:...|||||.........|||..:..:||.:|....:.|:.|
Mouse    80 TDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGEVEK 144

  Fly   165 LLVSGDTMDVVKQSAALCLLRLFRSSPDI----IPGGEWTSRIIHLLNDQHMGVVTAATSLIDAL 225
            ||.:.::  .:::.||||.:.:.|..|::    :|..:      :|||:::.||:..:..|:..:
Mouse   145 LLKTSNS--YLRKKAALCAVHVIRKVPELMEMFLPATK------NLLNEKNHGVLHTSVVLLTEM 201

  Fly   226 VKRNPD------EYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTE 284
            .:|:||      :.:..|...|..|..::.:.|:...|.:  .:..|:|.|::||||:......:
Mouse   202 CERSPDMLAHFRKNEKLVPQLVRILKNLIMSGYSPEHDVS--GISDPFLQVRILRLLRILGRNDD 264

  Fly   285 EAGVRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQF 349
            ::      :|.:..||.:.....::.|    |..||:|:|.:..|:...||..|.|.|.|.||:|
Mouse   265 DS------SEAMNDILAQVATNTETSK----NVGNAILYETVLTIMDIKSESGLRVLAINILGRF 319

  Fly   350 LSNRETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNA 414
            |.|.:.|:||:||.|:  |.|.:..|..|::|:..::..:| :.|||:::.|::|.:|:.:..|.
Mouse   320 LLNNDKNIRYVALTSL--LKTVQTDHNAVQRHRSTIVDCLK-DLDVSIKRRAMELSFALVNGNNI 381

  Fly   415 EEIVQEMLNYLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQ 479
            ..:::|:|.:|::.:...:.:....:.:.|||||....|::|.|:.::..||.||.::....:||
Mouse   382 RGMMKELLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQ 446

  Fly   480 IVINREEVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGN-LIAGDSRSAPLVQ------FKL 537
            ::.|..|:..|..:.:::|:......:.:|:|..:.:||:|: |::|.......:|      ..:
Mouse   447 LITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCIGEYGDLLVSGQCEEEEPIQVTEDEVLDI 511

  Fly   538 LHSKY--HLCSPMTRALLLSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSI 600
            |.|..  ::.:.:||...|:..:|....|......|:.|...:.:  |.|.||||||.||..| .
Mouse   512 LESVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRIKKVVSIYGS--SIDVELQQRAVEYNAL-F 573

  Fly   601 VASTDVLATVLEEMPSFPERESSILAVLKKKKPGRVPENEIRESKSPAPLTS---------AAQN 656
            .....:.:.:||.||        ::..:....|..:.:.  .....||||.:         .:|.
Mouse   574 KKYDHMRSALLERMP--------VMEKVTTNGPSEIVQT--NGETEPAPLETKPPPSGPQPTSQA 628

  Fly   657 NALVNNSHSKLNNSNANTDLLGLS--TP--PSNNIGSGSNSNSTLIDVLGD--MYGSNSNNNSSA 715
            |.|:              ||||.:  ||  |:......:::...|:|:|||  :.|:.:...:.|
Mouse   629 NDLL--------------DLLGGNDITPVIPTAPTSKPASAGGELLDLLGDITLTGAPAAAPTPA 679

  Fly   716 -VYNTKKFLFKNNGV----LFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLT----NFNP--- 768
             |....:..|..:|:    ||.:  :..|:.|        :..:..|..::..|    |.||
Mouse   680 SVPQISQPPFLLDGLSSQPLFND--IAPGIPS--------ITAYSKNGLKIEFTFERSNTNPSVT 734

  Fly   769 VLQWSAEDALKLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADAPTI-EISFRYNGTQQKFSIKL 832
            |:...|.::.:|::...|.:..:....|:|.|..:..:....:..|| ::....|..:|:..:::
Mouse   735 VITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSVVPAFNTGTITQVIKVLNPQKQQLRMRI 799

  Fly   833 PLSVN 837
            .|:.|
Mouse   800 KLTYN 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	161/576 (28%)
		Alpha_adaptinC2	730..839	CDD:197886	21/115 (18%)
		Alpha_adaptin_C	839..947	CDD:280460
Ap1g1	NP_033807.2	Adaptin_N	23..577	CDD:396262	162/582 (28%)
		HEAT repeat	142..163	CDD:293787	7/22 (32%)
		HEAT repeat	175..203	CDD:293787	7/33 (21%)
		HEAT repeat	246..276	CDD:293787	10/35 (29%)
		HEAT repeat	287..319	CDD:293787	13/31 (42%)
		Herpes_BLLF1	<593..>705	CDD:282904	27/129 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..630		6/35 (17%)
		Alpha_adaptinC2	712..820	CDD:197886	17/92 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53727
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820