DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AP-2alpha and Ap4e1

DIOPT Version :9

Sequence 1:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	XP_006498611.1	Gene:	Ap4e1 / 108011	MGIID:	1336993	Length:	1131	Species:	Mus musculus

Alignment Length:	1085	Identity:	221/1085 - (20%)
Similarity:	418/1085 - (38%)	Gaps:	332/1085 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SKEAEVKRINKELANIRSKFKGD----KTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSS 96
            ||..|.|.|.:||:::::.....    ||:     |:.:.:|::..:||:|..||::.|:.|...
Mouse    47 SKHEEEKLIQQELSSLKATVSAPTTTLKTM-----KECMVRLIYCEMLGYDASFGYIHAIKLAQQ 106

  Fly    97 NKYSEKQIGYLFISVLVNTNSDLIRLIIQSIK---------NDLQSRNPVHVNLALQCIANIGSR 152
            ....||::|||.:|:.::.:.:|:.|::.::.         .||||.|.|.|.:||..::.|..|
Mouse   107 GNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKTVFFACLWQDLQSTNLVEVCMALTVVSQIFPR 171

  Fly   153 DMAESFSNEIPKLL-VSGDTM----DVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIH-----LL 207
            :|       ||.:| :..|.:    :::::.|.|.|.:.:..:|:.:       :.||     .|
Mouse   172 EM-------IPAVLPLIEDKLQHSKEIIRRKAVLALYKFYLIAPNQV-------QHIHTKFRKAL 222

  Fly   208 NDQHMGVVTAATSLIDALVKRNPDEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKL 272
            .|:.:||:.|:..:...::|.|...||......|:.|.::|.....  .:::|:.||||||.::|
Mouse   223 CDRDVGVMAASLHIYLRMIKENASGYKDLTESFVTILKQVVGGKLP--VEFSYHSVPAPWLQIQL 285

  Fly   273 LRLLQNYNPVTEEAGVRARLNE-TLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEP 336
            ||:|          |:..:.:| |.|.:.:...|..:..::.| |...|:|||.::.|.....:.
Mouse   286 LRIL----------GLLGKDDERTSELMYDVLDESLRRAELNH-NVTYAILFECVHTIYSIYPKS 339

  Fly   337 NLLVRACNQLGQFLSNRETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMA 401
            .||.:|...:|:|:.:.:.||:||.|:::.::...:.|   :....::.|:......|..:::..
Mouse   340 ELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPS---LALQHQITIIECLDHPDPIIKRET 401

  Fly   402 VDLLYAMCDRGNAEEIVQEMLNYLETADYSIREEMVL-----KVAILAEKYATDYTWYVDVILNL 461
            ::|||.:.:..|...|||:||.||    :..:||.::     ::|.||||||.|..|::..:..:
Mouse   402 LELLYRITNAQNVVVIVQKMLEYL----HQSKEEHIIISLVGRIAELAEKYAPDNVWFIQTMNAV 462

  Fly   462 IRIAGDYVSEEVWYRVIQIVINREEVQGYAAKTVFEALQAPACH--------------ENMVKVG 512
            ..:.||.:..::....::::     .:|:..:|..:.|:..|..              :..::|.
Mouse   463 FSVGGDVMHPDILSNFLRLL-----AEGFDDETEDQQLRLYAVQSYLTLLDMENTFYPQRFLQVM 522

  Fly   513 GYILGEFGNLIAGDSRSAPLVQ-FKLLHSKYHLCSPMTRALLLSTYIKFI----------NLFPE 566
            .::|||:..|:..:|....:.: :|||.|  ...|..|:|.|.:...|..          .|..|
Mouse   523 SWVLGEYSYLLDKESPEEVITRLYKLLMS--DSISSETKAWLFAAVTKLTPQAHSSPLVEKLIQE 585

  Fly   567 IRTNIQDVFRQHS---------------------NLRS--ADAEL-------------------- 588
            ...::....|||:                     |...  |||.|
Mouse   586 FTVSLNTCLRQHAFELKHLHENTELMKSLLQGAQNCEDIVADASLSFLDGFVAEGLSQGAAPYKP 650

  Fly   589 -QQRASEYLQ-----------LSIVAS--------------TDVLATVLEEMPSFPERESSILAV 627
             .||..|.|.           ||..:|              :|:.....|  ....|..|..:..
Mouse   651 HHQRQEEQLSQEKVLNFEPYGLSFSSSGFTGRQSPAGISLGSDISGNSAE--TGLKETSSLKMEG 713

  Fly   628 LKK--KKPGRVPENEIRESKSP----------------------------APLTSAAQNNALVNN 662
            :||  .|.|.:|:.|......|                            .|.|...:...|.::
Mouse   714 IKKLWGKEGYLPKKESGTGDKPEASHVPAEGATVENVDQATTRKDQAQGHIPSTEEKEKQLLASS 778

  Fly   663 SHSKLNNSNANTDLLGLS--------------------TPPS-----------NNIGSGSNSNST 696
            ....|...| ..||||.:                    ||.:           :::..|.....:
Mouse   779 LFVGLGPEN-TVDLLGKADVVSHKFRRKSKLKVAQSDKTPSAPTAPCSALSLGSDVAGGDEDGLS 842

  Fly   697 LID-----VLGDMYGSNS-----------------------NN-------NSSAVYNTKKFL--F 724
            .:|     :..:::.|.|                       ||       :|||....|:..  .
Mouse   843 AVDRGDGELSSELFRSESLSGPPSAEKLESVSLPVPSLFADNNMEVFNPPSSSATSTVKEETPEC 907

  Fly   725 KNNGV--LFENEMLQIG-------------------VKSEFRQNLGRLGLFYGNKTQVPLTNF-- 766
            :::|:  :..||.:.:.                   ..|||..  .:|.:|       |:.||
Mouse   908 RHSGLVEICSNEAVSVSSYKVWRDDCLLVIWAVTSKTDSEFTD--AQLEIF-------PVENFKI 963

  Fly   767 -------NPVLQWSAEDALKLNVQMK--VVEPTLEAGAQIQQLLTAECIEDYADAPTIEISFRYN 822
                   :||::.....:.:.:|||:  .:|.||....:.|.:.|                   :
Mouse   964 IEQPECSSPVIETERTKSFQYSVQMESPCIEGTLSGFIKYQMMDT-------------------H 1009

  Fly   823 GTQQKFSIKLPLSVNKFFEPTEMNAESFFARWKNLSGEQQRSQKV 867
            ..|.:||:.|||.  .|..|.:::.|.|...|.:.:.:.:::.|:
Mouse  1010 SVQLEFSMNLPLL--DFIRPLKISTEDFGKLWLSFANDVKQTIKI 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	151/666 (23%)
		Alpha_adaptinC2	730..839	CDD:197886	26/138 (19%)
		Alpha_adaptin_C	839..947	CDD:280460	6/29 (21%)
Ap4e1	XP_006498611.1	Adaptin_N	51..601	CDD:366724	142/595 (24%)
Ap4e1	XP_006498611.1	AP4E_app_platf	1027..1127	CDD:373308	5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810