DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP-2alpha and Ap1g2

DIOPT Version :9

Sequence 1:NP_995607.1 Gene:AP-2alpha / 33211 FlyBaseID:FBgn0264855 Length:952 Species:Drosophila melanogaster
Sequence 2:XP_002728326.1 Gene:Ap1g2 / 100362547 RGDID:2324507 Length:785 Species:Rattus norvegicus


Alignment Length:665 Identity:189/665 - (28%)
Similarity:323/665 - (48%) Gaps:88/665 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 IDQSRGGKESEASADESLLFYCKSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIF 77
            |::.||.|             .:::|.||  |.||.|.||:.|:..   |..|:.:.:.|||::.
  Rat    11 IEEIRGAK-------------TQAQEREV--IQKECAQIRASFRDG---DPLQRHRQLAKLLYVH 57

  Fly    78 LLGHDIDFGHMEAVNLLSSNKYSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDL-QSRNPVHVNL 141
            :||:...||.||.:.|::|.::::|::|||...:|::...|...||..|||||| |...||. .|
  Rat    58 MLGYPAHFGQMECLKLIASPRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQ-GL 121

  Fly   142 ALQCIANIGSRDMAESFSNEIPKLLVSGDTMDVVKQSAALCLLRLFRSSPDIIPGGEWTSRII-- 204
            ||..::.:||.:|....:.|:.||.  ......|::.|.|..:.:.|..|::       |.|.  
  Rat   122 ALCTLSTMGSAEMCRDLATEVEKLF--QQPSPYVRKKAILAAVHMIRKDPEL-------SNIFLP 177

  Fly   205 ---HLLNDQHMGVVTAATSLIDALVKRNP---DEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFV 263
               .||.::|.|.:....:||..|.:|||   ..::..|...|..|..:||..|:  .:::...|
  Rat   178 PCTKLLRERHHGTLLGTITLITELCERNPAALRHFRKVVPQLVQILRTLVTTGYS--TEHSISGV 240

  Fly   264 PAPWLSVKLLRLLQNYNPVTEEAGVRARLNETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINL 328
            ..|:|.|::||||:......||:      :||:..:|.:......:.:    ||.||||.|.:..
  Rat   241 SDPFLQVQILRLLRILGRNHEES------SETMNDLLAQVATNTDTSR----NAGNAVLLETVLT 295

  Fly   329 IIHSDSEPNLLVRACNQLGQFLSNRETNLRYLALESMCHLATSEFSHEEVKKHQEVVILSMKMEK 393
            |:...|...|.|.|.|.||:||.|.:.|:||:||.|:..|..|:  |..|::|:..|:..:: ||
  Rat   296 IMAIHSAAGLRVLAVNILGRFLLNNDKNIRYVALTSLLQLVQSD--HSAVQRHRSTVVECLQ-EK 357

  Fly   394 DVSVRQMAVDLLYAMCDRGNAEEIVQEMLNYLETADYSIREEMVLKVAILAEKYATDYTWYVDVI 458
            |.|:.:.|::|..|:.:..|...::||:..:||:....:|.:....:.:.||::|....|::|.|
  Rat   358 DASLSRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPSKRWHIDTI 422

  Fly   459 LNLIRIAGDYVSEEVWYRVIQIVINREEVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGN-L 522
            |:::..||.:|.::....:.|::...||:..|:.:.::.||......:.:|:|..:.:||:|: |
  Rat   423 LHVLTTAGTHVRDDAVANLTQLIGEAEELHTYSVRRLYSALAEDISQQPLVQVAAWCIGEYGDLL 487

  Fly   523 IAGDSRSAPLVQF----------KLLHSKYHLCSPMTRALLLSTYIKFINLFPEIRTNIQDVFRQ 577
            :.|:.......|.          |:|.|  |:..|.||...::..:|...........|:.|...
  Rat   488 LEGNCEETEPFQVEEEDVLALLEKVLQS--HMSLPATRGYAITALMKLSTRLQGDNNRIRQVVSI 550

  Fly   578 HSNLRSADAELQQRASEYLQLSIVASTDVL--------ATVLEEMPSFPERESSILAVLKKKKPG 634
            :.:  ..|.||||||.||         :||        |.:||:||.....:..:....|:|:.|
  Rat   551 YGS--CMDIELQQRAVEY---------NVLFQKYDHMRAAILEKMPLVERSDPQVNEEGKEKQTG 604

  Fly   635 RVPENEIRESKSPAP 649
            ..|    .|:.:|.|
  Rat   605 AQP----LEATAPVP 615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP-2alphaNP_995607.1 Adaptin_N 40..598 CDD:279882 170/577 (29%)
Alpha_adaptinC2 730..839 CDD:197886
Alpha_adaptin_C 839..947 CDD:280460
Ap1g2XP_002728326.1 Adaptin_N 23..574 CDD:279882 173/593 (29%)
Alpha_adaptinC2 672..780 CDD:197886
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG4354
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53727
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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