DRSC/TRiP Functional Genomics Resources

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Protein Alignment RpI135 and POLR1B

DIOPT Version :9

Sequence 1:NP_476708.1 Gene:RpI135 / 33210 FlyBaseID:FBgn0003278 Length:1129 Species:Drosophila melanogaster
Sequence 2:NP_001358898.1 Gene:POLR1B / 84172 HGNCID:20454 Length:1181 Species:Homo sapiens


Alignment Length:1184 Identity:516/1184 - (43%)
Similarity:721/1184 - (60%) Gaps:95/1184 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SRPEFKQ-------IPKKLSR-HLANLGGPHVDSFDEMLTVGLDNSAKHMIPNHWLSPAGEKISM 73
            |.|..|.       ||::..: .|..|...||:||:..:..|| ..|...||....:...|:||.
Human    12 SGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGL-GLAVQAIPPFEFAFKDERISF 75

  Fly    74 KVESIWIAKPKVPQDVIDVRTREIYPTDSRQLHVSYSGMCSVRLGWSVNGVQKTPINMDLGEVPI 138
            .:....|:.|.||:..| .:...:||.:.|....:|.|..:..:.|:|||:.|..|...||.|||
Human    76 TILDAVISPPTVPKGTI-CKEANVYPAECRGRRSTYRGKLTADINWAVNGISKGIIKQFLGYVPI 139

  Fly   139 MLRSKACNLGQATPEEMVKHGEHDSEWGGIFVIRGNEKIVRMLIMTRRNHPICVKRSSWKDRGQN 203
            |::||.|||....|:.:::|.|...|.||.|:|.|.||::|||||.|||.||.:.|..||.||..
Human   140 MVKSKLCNLRNLPPQALIEHHEEAEEMGGYFIINGIEKVIRMLIMPRRNFPIAMIRPKWKTRGPG 204

  Fly   204 FSDLGMLVQTVREDESSLSNVVHYLNNGTAKFMFSHVKRLSYVPVCLILKCLMDYTDEEIYNRLV 268
            ::..|:.:..|||:.|:::..:|||.|||....|.:.|.|.::|:...||.|:.::|.:|:..|:
Human   205 YTQYGVSMHCVREEHSAVNMNLHYLENGTVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELI 269

  Fly   269 QGYESDQYYVSCVQAMLREVQNENVYTHAQCKSFIGNLFRARFPEVPEWQPDDDVTDFILRERVM 333
            :|.|.|.:..:.|..|||.|..|...|..|..:::|..||.:. .||:|.|::...:|:..:.:.
Human   270 KGKEDDSFLRNSVSQMLRIVMEEGCSTQKQVLNYLGECFRVKL-NVPDWYPNEQAAEFLFNQCIC 333

  Fly   334 IHLDTYEDKFQLIVFMIQKLFQCAQGKYKVENVDSAMMQEVLLPGHLYQKYLSERVESWVSQVRR 398
            |||.:..:||.::..|.:|||..|:|:...:|.||.:.||||.||.|:..:|.|::|.|:..::.
Human   334 IHLKSNTEKFYMLCLMTRKLFALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKI 398

  Fly   399 CLQKKLTSPDALVTSAVMTQCMRQAGGVGRAIESFLATGNIASRTGLGLMQNSGLVIMAENINRM 463
            ...||.......:.:..:.:.......:.:..|...||||:.|:|||||:|:|||.::|:.:|.:
Human   399 AFDKKAQKTSVSMNTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVADKLNFI 463

  Fly   464 RYMSHFRAIHRGSYFTTMRTTEARQLLPDAWGFICPVHTPDGTPCGLLNHLTLTCEISMRPDPKL 528
            ||:||||.:|||:.|..||||..|:|||::|||:||||||||.||||:||||..||:..:  ...
Human   464 RYLSHFRCVHRGADFAKMRTTTVRRLLPESWGFLCPVHTPDGEPCGLMNHLTAVCEVVTQ--FVY 526

  Fly   529 VKAIPKHLIDMGMMPLS---NRRYLGEKLYVVFLDGKHLGHIHQSEAEKIVDELRYGK------- 583
            ..:||..|.::|:.|:.   :|.|  .:.|.|.|||..:|.:.:..|..|.|.||:.|       
Human   527 TASIPALLCNLGVTPIDGAPHRSY--SECYPVLLDGVMVGWVDKDLAPGIADSLRHFKSLALSPR 589

  Fly   584 ------------------------------IFGT-----------LPQMMEIGFIPFK-KNGQFP 606
                                          |.|.           :|..||:..||.. |...:|
Human   590 LQCSGVILAHCSLRLPCSSNSPASVSQVAGITGAHHHAWVLREKRIPPWMEVVLIPMTGKPSLYP 654

  Fly   607 GLYIATGPARMMRPVWNLKWKRVEYIGTLEQLYMEIAIDAKEMYPDFTTHLELAKTHFMSNLANL 671
            ||::.|.|.|::|||.||...:.|.|||:||::|.:||...|::...|||.||.....:|.:||.
Human   655 GLFLFTTPCRLVRPVQNLALGKEELIGTMEQIFMNVAIFEDEVFAGVTTHQELFPHSLLSVIANF 719

  Fly   672 IPMPDYNQSPRNMYQCQMGKQTMGTPCLNWPKQAANKLYRLQTPGTPLFRPVHYDNIQLDDFAMG 736
            ||..|:||||||||||||||||||.|.|.:..::.|||||||||.:||.||..||...:|::.:|
Human   720 IPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQTPQSPLVRPSMYDYYDMDNYPIG 784

  Fly   737 TNAIVAVISYTGYDMEDAMIINKAAYERGFAYGSIYKTKFLTLDKK------SSYFARHPHMPEL 795
            ||||||||||||||||||||:|||::|||||:||:||::|:.|.:|      |..|...|..|.:
Human   785 TNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFIDLSEKIKQGDSSLVFGIKPGDPRV 849

  Fly   796 IKHLDTDGLPHPGSKLSYGSPLYCYFDGEVATYKVVKMDEKEDCIVESIRQLGSFDLSPK-KMVA 859
            ::.||.||||..|:||.||.|.|.|.:.......|:....||:|:|::|:...:...|.| |.|.
Human   850 LQKLDDDGLPFIGAKLQYGDPYYSYLNLNTGESFVMYYKSKENCVVDNIKVCSNDTGSGKFKCVC 914

  Fly   860 ITLRVPRPATIGDKFASRAGQKGICSQKYPAEDLPFTESGLIPDIVFNPHGFPSRMTIAMMIETM 924
            ||:||||..|||||||||.|||||.|:.:||||:||||||::|||:||||||||||||.|:||:|
Human   915 ITMRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMVPDILFNPHGFPSRMTIGMLIESM 979

  Fly   925 AGKGAAIHGNVYDATPFRFSEENTAIDYFGKMLEAGGYNYYGTERLYSGVDGREMTADIFFGVVH 989
            |||.||:||..:|||||.|||||:|::|||:||:|.|||:|||||||||:.|.|:.||||.|||:
Human   980 AGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLYSGISGLELEADIFIGVVY 1044

  Fly   990 YQRLRHMVFDKWQVRSTGAVEARTHQPIKGRKRGGGVRFGEMERDALISHGAAFLLQDRLFHNSD 1054
            ||||||||.||:|||:|||.:..|:|||.||...||:||||||||||::||.:|||.||||:.||
Human  1045 YQRLRHMVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSD 1109

  Fly  1055 KTHTLVCHKCGSILAPLQRIVKRNETGGLSSQPDT----------CRLCGDNSSVSMIEIPFSFK 1109
            ::...||.||||:|:||           |...|.:          |.||..:.::..:.:|:.|:
Human  1110 RSVAHVCVKCGSLLSPL-----------LEKPPPSWSAMRNRKYNCTLCSRSDTIDTVSVPYVFR 1163

  Fly  1110 YLVTELSSVNINAR 1123
            |.|.||:::||..:
Human  1164 YFVAELAAMNIKVK 1177

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RpI135NP_476708.1 RpoB 34..1128 CDD:223163 510/1159 (44%)
RNA_pol_B_RPB2 35..1125 CDD:238353 510/1158 (44%)
RNA_pol_Rpa2_4 564..614 CDD:284335 19/98 (19%)
POLR1BNP_001358898.1 RNA_pol_B_RPB2 38..1179 CDD:238353 510/1158 (44%)
RNA_pol_Rpb2_2 186..375 CDD:367992 66/189 (35%)
RNA_pol_Rpa2_4 563..662 CDD:369122 19/98 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147096
Domainoid 1 1.000 447 1.000 Domainoid score I522
eggNOG 1 0.900 - - E1_COG0085
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7133
Inparanoid 1 1.050 982 1.000 Inparanoid score I311
Isobase 1 0.950 - 0 Normalized mean entropy S774
OMA 1 1.010 - - QHG53969
OrthoDB 1 1.010 - - D42570at2759
OrthoFinder 1 1.000 - - FOG0000346
OrthoInspector 1 1.000 - - oto90774
orthoMCL 1 0.900 - - OOG6_102249
Panther 1 1.100 - - LDO PTHR20856
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3081
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.720

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