DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpI135 and NRPD2A

DIOPT Version :9

Sequence 1:	NP_476708.1	Gene:	RpI135 / 33210	FlyBaseID:	FBgn0003278	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_001189957.1	Gene:	NRPD2A / 821960	AraportID:	AT3G23780	Length:	1172	Species:	Arabidopsis thaliana

Alignment Length:	1185	Identity:	316/1185 - (26%)
Similarity:	509/1185 - (42%)	Gaps:	189/1185 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SFDEMLTVGLDNSAKHMIPNHWLSPAGEKISMKVESIWIAKPKVPQDVIDVRTREIYPTDSRQLH 106
            ||.|||.....:..|.. .|.|     ...::|...:.:.||..   ..|.:..|..|..:|..:
plant    70 SFGEMLVEPSFDVVKKK-DNDW-----RYATVKFGEVTVEKPTF---FSDDKELEFLPWHARLQN 125

  Fly   107 VSYSGMCSVRLGWSV----------------NGVQKTPINMD-----LGEVPIMLRSKACNLGQA 150
            ::||....|.:...|                |.|:|..:::.     :|.:|:|::|..|...:
plant   126 MTYSARIKVNVQVEVFKNTVVKSDKFKTGQDNYVEKKILDVKKQDILIGSIPVMVKSILCKTSE- 189

  Fly   151 TPEEMVKHGEHDSEWGGIFVIRGNEK--IVRMLIMTRRNHPICVKRSSWKDRGQNFSDLGMLVQT 213
            ..:|..|.|:...:.||.|||:|.||  |.:..:.|:|   :.:..|.|....::.:.....:..
plant   190 KGKENCKKGDCAFDQGGYFVIKGAEKVFIAQEQMCTKR---LWISNSPWTVSFRSENKRNRFIVR 251

  Fly   214 VREDESSLSN-------VVHYLNNGTAKFMFSHVKRLSYVPVCLILKCL-------------MDY 258
            :.|:|.:...       .|::|:              :.:||.|:...|             .|.
plant   252 LSENEKAEDYKRREKVLTVYFLS--------------TEIPVWLLFFALGVSSDKEAMDLIAFDG 302

  Fly   259 TDEEIYNRLVQGYESDQYYVSCVQAMLREVQNENVYTHAQCKSFIGNLFRARFPEVPEWQPDDDV 323
            .|..|.|.|:    :..:....|....|...|...|...|.||       .:||      |.:.|
plant   303 DDASITNSLI----ASIHVADAVCEAFRCGNNALTYVEQQIKS-------TKFP------PAESV 350

  Fly   324 TDFILRERVMIHLDTYEDKFQLIVFMIQKLFQCAQGKYKVENVDSAMMQEVLLPGHLYQKYLSER 388
             |..|...:...|.:.:.|.:.:.:|::.|.....||.|.||.||...:.:.|.|.|.::.:...
plant   351 -DECLHLYLFPGLQSLKKKARFLGYMVKCLLNSYAGKRKCENRDSFRNKRIELAGELLEREIRVH 414

  Fly   389 VESWVSQVRRCLQKKLTSPDAL------VTSAVMTQCMRQAGGVGRAIESFLATGNIASRTGLGL 447
            :.....::.|.:||.|:....|      :.::|:|..:.:|...|.....|.....:
plant   415 LAHARRKMTRAMQKHLSGDGDLKPIEHYLDASVITNGLSRAFSTGAWSHPFRKMERV-------- 471

  Fly   448 MQNSGLVIMAENINRMRYMSHFRAIHRGSYFTTMRTTEARQLLPDAWGFICPVHTPDGTPCGLLN 512
               ||:|......|.::.:...|.. |.....|.:..:||...|..||.:|.:.||||..|||:.
plant   472 ---SGVVANLGRANPLQTLIDLRRT-RQQVLYTGKVGDARYPHPSHWGRVCFLSTPDGENCGLVK 532

  Fly   513 HLTLTCEISMRPDPKLVKAI----PKHLIDMGMMPLSNRRYLGEKLYVVFLDGKHLGHIHQSEAE 573
            :::|...:|.:....:|:.:    .:.|:|....||..:       :.|.|:|..:|..  :::|
plant   533 NMSLLGLVSTQSLESVVEKLFACGMEELMDDTCTPLFGK-------HKVLLNGDWVGLC--ADSE 588

  Fly   574 KIVDELRYGKIFGTLPQMMEIGFIPFKKNGQFPGLYIATGPARMMRP---VWNL-KWKR------ 628
            ..|.||:..:....||:.|||     |::.....:.|.|...|::||   |.|| |.|:
plant   589 SFVAELKSRRRQSELPREMEI-----KRDKDDNEVRIFTDAGRLLRPLLVVENLQKLKQEKPSQY 648

  Fly   629 ----------VEYIGTLEQLYMEIAIDAKEMY--PDFTTHLELAKTHFMSNLANLIPMPDYNQSP 681
                      :|.||..|:.....|...|::.  |...||.||..:..:.....::|..:::...
plant   649 PFDHLLDHGILELIGIEEEEDCNTAWGIKQLLKEPKIYTHCELDLSFLLGVSCAVVPFANHDHGR 713

  Fly   682 RNMYQCQMG-KQTMGTPCLNWPKQAANKL-YRLQTPGTPLFRPVHYDNIQLDDFAMGTNAIVAVI 744
            |.:||.|.. :|.:|....| |....:.| .:|..|..|||:.:..:.::.:....|.||||||.
plant   714 RVLYQSQKHCQQAIGFSSTN-PNIRCDTLSQQLFYPQKPLFKTLASECLKKEVLFNGQNAIVAVN 777

  Fly   745 SYTGYDMEDAMIINKAAYERGFAYGSIYKTKFLTLDKKSSYFARHPHMPELIK------------ 797
            .:.||:.||::::|||:.|||.......::....:|.|.|  .:...|.||::
plant   778 VHLGYNQEDSIVMNKASLERGMFRSEQIRSYKAEVDAKDS--EKRKKMDELVQFGKTHSKIGKVD 840

  Fly   798 HLDTDGLPHPGSKLSYGSPLY--CYFDGEVATYKVVKMDEKEDCIVESIRQLGSFDLSPKKMVAI 860
            .|:.||.|..|:.:|.|..:.  |...|  |.:. :|:...|..||:.: .|.|.| ..|...|:
plant   841 SLEDDGFPFIGANMSTGDIVIGRCTESG--ADHS-IKLKHTERGIVQKV-VLSSND-EGKNFAAV 900

  Fly   861 TLRVPRPATIGDKFASRAGQKGICSQKYPAEDLPFTESGLIPDIVFNPHGFPSRMTIAMMIETMA 925
            :||..|...:||||:|..||||:.......::.|||..|::||||.|||.||||.|...::|...
plant   901 SLRQVRSPCLGDKFSSMHGQKGVLGYLEEQQNFPFTIQGIVPDIVINPHAFPSRQTPGQLLEAAL 965

  Fly   926 GKG-----------AAIHGNVYDATPFRFSEENTAIDYFGKMLEAGGYNYYGTERLYSGVDGREM 979
            .||           ||.......||||    ....:....:.|...|::.:|.||:|:|..|..|
plant   966 SKGIACPIQKEGSSAAYTKLTRHATPF----STPGVTEITEQLHRAGFSRWGNERVYNGRSGEMM 1026

  Fly   980 TADIFFGVVHYQRLRHMVFDKWQVRSTGAVEARTHQPIKGRKRGGGVRFGEMERDALISHGAAFL 1044
            .:.||.|...||||.||..||.:.|:||.|...|.||:..|||.||::|||||||.||:|||:..
plant  1027 RSMIFMGPTFYQRLVHMSEDKVKFRNTGPVHPLTRQPVADRKRFGGIKFGEMERDCLIAHGASAN 1091

  Fly  1045 LQDRLFHNSDKTHTLVCHKCGSILAPLQRIVKRNETGGLSSQPDTCRLCGDNSSVSMIEIPFSFK 1109
            |.:|||..||.:...:|.||.:    ...:::|..:.|...:...||:|..:..|..:.:|:..|
plant  1092 LHERLFTLSDSSQMHICRKCKT----YANVIERTPSSGRKIRGPYCRVCVSSDHVVRVYVPYGAK 1152

  Fly  1110 YLVTELSSVNINARF 1124
            .|..||.|:.|...|
plant  1153 LLCQELFSMGITLNF 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpI135	NP_476708.1	RpoB	34..1128	CDD:223163	316/1185 (27%)
		RNA_pol_B_RPB2	35..1125	CDD:238353	316/1185 (27%)
		RNA_pol_Rpa2_4	564..614	CDD:284335	13/49 (27%)
NRPD2A	NP_001189957.1	RNA_pol_B_RPB2	48..1168	CDD:238353	316/1185 (27%)
NRPD2A	NP_001189957.1	RNA_pol_Rpb2_4	574..635	CDD:398322	19/67 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820