Protein Alignment RpI135 and POLR3B

DIOPT Version :9

• Sequence 1: NP_476708.1
• Gene: RpI135 / 33210
• FlyBaseID: FBgn0003278
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_060552.4
• Gene: POLR3B / 55703
• HGNCID: 30348
• Length: 1133
• Species: Homo sapiens
• Alignment Length: 1181
• Identity: 343/1181 - (29%)
• Similarity: 543/1181 - (45%)
• Gaps: 184/1181 - (15%)

  Fly    39 HVDSFDEMLTVGLDNSAKHMIPNHWLSPAGEKISMKVESIWIAK--------PKVPQDVIDVRTR 95
            |:|||:..:.|.:....|          |.||::...:.:|..|        |.| ::..:| ||
Human    43 HIDSFNYFINVEIKKIMK----------ANEKVTSDADPMWYLKYLNIYVGLPDV-EESFNV-TR 95

  Fly    96 EIYPTDSRQLHVSYSGMCSVRLGWSVNGVQKTPIN-MDLGEVPIMLRSKACNLGQATPEEMVKHG 159
            .:.|.:.|...::||...:|.:.:: .|.|:...| :.:|.:||||||..|.|...||.|..|..
Human    96 PVSPHECRLRDMTYSAPITVDIEYT-RGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLN 159

  Fly   160 EHDSEWGGIFVIRGNEKIVRMLIMTRRNHPICVKRSSWKDRGQNFSDLGMLVQTVREDESSLSNV 224
            |...:.||.|:::|.||::.:.....:|..|.        .......:|..|.:...::.|.:|:
Human   160 ECPLDPGGYFIVKGVEKVILIQEQLSKNRIIV--------EADRKGAVGASVTSSTHEKKSRTNM 216

  Fly   225 VHYLNNGTAKFMFSHVKRLSYVPVCLILKCLMDYTDEEIYNRLVQGYESDQYYVSCVQAMLREVQ 289
            .  :..|  :|...|......:|:.:|.|.:...:|:||    ||...::::.::.....|.|.|
Human   217 A--VKQG--RFYLRHNTLSEDIPIVIIFKAMGVESDQEI----VQMIGTEEHVMAAFGPSLEECQ 273

  Fly   290 NENVYTHAQCKSFIGNLFR-----------ARFPEVPEWQPDDDVTDFILRERVMIHLDTYEDKF 343
            ...::|..|...:|||..|           .:..|..|          :|...::.|:...|..|
Human   274 KAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARE----------LLASTILTHVPVKEFNF 328

  Fly   344 Q----LIVFMIQKLFQCAQGKYKVENVDSAMMQEVLLPGHLYQKYLSERVESWVSQVRRCLQKKL 404
            :    ....|::::. .|||..||::.|....:.:.|.|.|......:..:.:.|::::...:.:
Human   329 RAKCIYTAVMVRRVI-LAQGDNKVDDRDYYGNKRLELAGQLLSLLFEDLFKKFNSEMKKIADQVI 392

  Fly   405 TSPDALVTSAVMTQCMRQ---AGGVGRAIESFLATGNIASRTGLGLMQNSGLVIMAENINRMRYM 466
              |........:.:.|||   ..|:..||    :|||.:.:.  ..|...|   :.:.::|:.|:
Human   393 --PKQRAAQFDVVKHMRQDQITNGMVNAI----STGNWSLKR--FKMDRQG---VTQVLSRLSYI 446

  Fly   467 SHFRAIHR--GSYFTTMRTTEARQLLPDAWGFICPVHTPDGTPCGLLNHLTLTCEIS--MRPDPK 527
            |....:.|  ..:..|.:.:..|.|.|..||.:||..||:|..|||:.:|.|...|:  |...|.
Human   447 SALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPI 511

  Fly   528 LVKAIPKHLIDMGMMPLSNRRYLGEKL-----YVVFLDGKHLGHIHQSEAEKIVDELRYGKIFGT 587
            :..|....:.|:.::       .||:|     ::|||:|..||.|.  :.:|:|:..|..:..|.
Human   512 VKLASNLGVEDVNLL-------CGEELSYPNVFLVFLNGNILGVIR--DHKKLVNTFRLMRRAGY 567

  Fly   588 LPQMMEIGFIPFKKNGQFPGLYIATGPARMMRPVWNLKWKR------------------------ 628
            :.:     |:....|.....:||::...|:.||...:|.::
Human   568 INE-----FVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHE 627

  Fly   629 --VEYIGTLEQLYMEIAIDAKEMYPDFTTHLELAKTHFMSNLANLIPMPDYNQSPRNMYQCQMGK 691
              |||:...|:....||:....:..| |||||:.....:...|.|||.|.:||||||.|||.|||
Human   628 SLVEYLDVNEENDCNIALYEHTINKD-TTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGK 691

  Fly   692 QTMGTPCLNWPKQAANKLYRLQTPGTPLFRPVHYDNIQLDDFAMGTNAIVAVISYTGYDMEDAMI 756
            |.|||...|...:....:|.|..|..|:.:....:.|:.:....|.||.|||:||:|||:|||::
Human   692 QAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALV 756

  Fly   757 INKAAYERGFAYGSIYKTKFLTLDKKSSY------------FARHPHMPELIKH--LDTDGLPHP 807
            :|||:.:|||....:||....||.:.::.            ..|.|    :.:|  ||.||:..|
Human   757 LNKASLDRGFGRCLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKP----IWRHEILDADGICSP 817

  Fly   808 GSKL---------SYGSPLYCYFDG----EVATYKVVKMDEK--EDCIVESIRQLGSFDLSPKKM 857
            |.|:         |..:......:|    :...||.|.:..|  .|..:|.:  :.|.:.....:
Human   818 GEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKV--MISSNAEDAFL 880

  Fly   858 VAITLRVPRPATIGDKFASRAGQKGICSQKYPAEDLPFTESGLIPDIVFNPHGFPSRMTIAMMIE 922
            :.:.||..|...|||||:||.||||:|....|.||:||.:||:.|||:.||||||||||:..:||
Human   881 IKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIE 945

  Fly   923 TMAGKGAAIHGNVYDATPFRFSEENTAIDYFGKMLEAGGYNYYGTERLYSGVDGREMTADIFFGV 987
            .:|||...:.|..:..|.|..|:.....:    .|...||||.|.:.:.||:.|..:.|.|:||.
Human   946 LLAGKAGVLDGRFHYGTAFGGSKVKDVCE----DLVRHGYNYLGKDYVTSGITGEPLEAYIYFGP 1006

  Fly   988 VHYQRLRHMVFDKWQVRSTGAVEARTHQPIKGRKRGGGVRFGEMERDALISHGAAFLLQDRLFHN 1052
            |:||:|:|||.||...|:.|.....|.||.:||.|.||:|.||||||.||.:||:.||.:||..:
Human  1007 VYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMIS 1071

  Fly  1053 SDKTHTLVCHKCGSILAPLQRIVKRNETGGLSSQPDTCRLCGDNSSVSMIEIPFSFKYLVTELSS 1117
            ||.....||.:||.:              |.|.   .|..|..:..||.:.||::.|.|..||.|
Human  1072 SDAFEVDVCGQCGLL--------------GYSG---WCHYCKSSCHVSSLRIPYACKLLFQELQS 1119

  Fly  1118 VNINARFKLNE 1128
            :||..|.||::
Human  1120 MNIIPRLKLSK 1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RpI135	NP_476708.1	RpoB	34..1128	CDD:223163	343/1179 (29%)
		RNA_pol_B_RPB2	35..1125	CDD:238353	341/1176 (29%)
		RNA_pol_Rpa2_4	564..614	CDD:284335	11/49 (22%)
POLR3B	NP_060552.4	RNA_pol_B_RPB2	39..1127	CDD:238353	341/1176 (29%)
		RNA_pol_Rpb2_4	539..600	CDD:398322	18/67 (27%)
		RNA_pol_Rpb2_5	621..661	CDD:398323	12/40 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820