Protein Alignment Polr1B and RpIII128

DIOPT Version :10

• Sequence 1: NP_476708.1
• Gene: Polr1B / 33210
• FlyBaseID: FBgn0003278
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: XP_061510195.1
• Gene: RpIII128 / 1277811
• VectorBaseID: AGAMI1_012803
• Length: 1134
• Species: Anopheles gambiae
• Alignment Length: 1223
• Identity: 329/1223 - (26%)
• Similarity: 533/1223 - (43%)
• Gaps: 211/1223 - (17%)

  Fly     2 LEEMQQMKTIPVLTNSRPEFKQIPKKLSRHLANLGGPHVDSFDEMLTVGLDN--SAKHMIPNHWL 64
            |||  :.|.:|.....:...||               |:|||:..:.|.:..  .|...:.
Mosquito    22 LEE--KWKLVPAFLQVKGLVKQ---------------HIDSFNYFINVDIKKIVQANQEVK---- 65

  Fly    65 SPAGEKISMKVESIWIAKPKVPQDVIDVRTREIYPTDSRQLHVSYSGMCSVRLGWSVNGVQKTPI 129
            |.|.....:|..::.:.||.|.:...:  |:...|.:.|...::||...:|.:.:: .|.|:...
Mosquito    66 SDADPCFYLKYLNVHVGKPDVEEGFNN--TKSTTPHECRLRDMTYSAPITVDIEYT-RGTQRVVR 127

  Fly   130 N-MDLGEVPIMLRSKACNLGQATPEEMVKHGEHDSEWGGIFVIRGNEKIVRMLIMTRRNHPICVK 193
            | :.:|.:||||||..|.|...:..::.|..|...:.||.|:|||.||::           :..:
Mosquito   128 NGLLIGRMPIMLRSSNCVLTGKSDYQLSKVNECPMDPGGYFIIRGTEKVI-----------LIQE 181

  Fly   194 RSSWKDRGQNFSDLGMLVQTVRED-----ESSLSNVVHYLNNGT------AKFMFSHVKRLSYVP 247
            :.||.             :.:.||     :..:::..|...:.|      .::...|......:|
Mosquito   182 QLSWN-------------KMITEDYNGVIQCQVTSSTHEKKSRTILLTKHGRYYLKHNSMTEEIP 233

  Fly   248 VCLILKCLMDYTDEEIYNRLVQGYESDQYYVSCVQAMLREVQNENVYTHAQCKSFIGN-LFRARF 311
            |.:|||.:...:|:||...:....|:.:.:.    ..|.|..|..|:|..:...::|: |...||
Mosquito   234 VAIILKAMGIASDQEIMQLVGIDPETQKRFA----PSLLEAANHKVFTQQRALEYMGSKLIAKRF 294

  Fly   312 -PEVPEWQPDDDVTDFILRERVMIHLDTYEDKFQL----IVFMIQKLFQCAQGKYKVENVDSAMM 371
             ....:::...|....:|...::.|:......||:    :..||:::......:..|::.|....
Mosquito   295 TTAATKYKTTADEARDLLATTILAHVPVPSFNFQVKAIYVALMIRRVMAAELDRSAVDDRDYYGN 359

  Fly   372 QEVLLPGHLYQKYLSERVESWVSQVRRCLQKKLTSPDALVTSAVMTQCMRQAGGVGRAIESFLAT 436
            :.:.|.|.|......:..:.:..:::....|.:  |........:.:.||:| .:...:|:.::|
Mosquito   360 KRLELAGSLLSLMFEDLFKRFNWELKMIADKNI--PKIKAAQFDVGKHMREA-LITAGLETAIST 421

  Fly   437 GNIASRTGLGLMQNSGLVIMAENINRMRYMSHFRAIHR--GSYFTTMRTTEARQLLPDAWGFICP 499
            ||...:.  ..|:.:|   :.:.::|:.|:|....:.|  ..:..|.:.:..|.|.|..||.:||
Mosquito   422 GNWTIKR--FKMERAG---VTQVLSRLSYISALGMMTRVNSQFEKTRKVSGPRSLQPSQWGMLCP 481

  Fly   500 VHTPDGTPCGLLNHLTLTCEISMRPD--PKLVKAIPKHLIDMGMMPLSNRRYLGEKLYVVFLDGK 562
            ..||:|..|||:.:|.|...|:...|  |.:..|....:.|:.:  |........|:::||::|.
Mosquito   482 SDTPEGEACGLVKNLALMTHITTEVDEEPVIRLAYNAGVEDIRL--LGGETINNPKVFMVFINGN 544

  Fly   563 HLGHIHQSEAEKIVDELRYGKIFGTLPQMMEIGFIPFKKNGQFPGL---------YIATGPARMM 618
            .||           ..:.|.::......|...|.|     |.|..:         ||.|...|:.
Mosquito   545 ILG-----------VTIAYRRLVEVFRMMRRRGLI-----GAFVSIHTSFTQRCVYIHTDGGRLC 593

  Fly   619 RPVWNLKWKR--------------------------VEYIGTLEQLYMEIAIDAKEMYPDFTTHL 657
            ||...::..|                          :||:...|:....||...:::.|:.||||
Mosquito   594 RPYIIVQAGRPLVLQEHLEQMKLGLRKFDDFLHDGLIEYLDVNEENDSFIAYQERDIDPEKTTHL 658

  Fly   658 ELAKTHFMSNLANLIPMPDYNQSPRNMYQCQMGKQTMGTPCLNWPKQAANKLYRLQTPGTPLFRP 722
            |:.....:...|.|:|.|.:||||||.|||.||||.||....|...:....:|.:..|.:|:.|.
Mosquito   659 EIEPFTLLGVCAGLVPYPHHNQSPRNTYQCAMGKQAMGIIGYNQKNRIDTLMYNIVYPQSPMVRS 723

  Fly   723 VHYDNIQLDDFAMGTNAIVAVISYTGYDMEDAMIINKAAYERGFAYGSIYKTKFLTLDKKSS--- 784
            ...:....|....|.||.|||:||:|||:|||:|:|||:.:||:....:||....|:.:.|:
Mosquito   724 RTIELTNFDKLPAGQNATVAVMSYSGYDIEDALILNKASIDRGYGRCLVYKNSKCTIKRYSNQTF 788

  Fly   785 --------------YFARHPHMPELIKHLDTDGLPHPGSKLS--------------YGSPLYCYF 821
                          ..|:|       :.|||||:..||.:|:              ..:|:....
Mosquito   789 DRIMGPMKDGVTGKIIAKH-------ECLDTDGIVSPGERLTCKQTMVNKEMPAVKSNNPIEQKE 846

  Fly   822 DGE--------VATYKVVKMDEKEDCIVESIRQLGSFDLSPKKMVAITLRVPRPATIGDKFASRA 878
            .|:        ..|||..:....|       |.|.|.:...:.:|.|.||..|...|||||:||.
Mosquito   847 SGQQPIAYSAVPVTYKGTEPSYAE-------RVLVSTNNEEEFLVKILLRQTRRPEIGDKFSSRH 904

  Fly   879 GQKGICSQKYPAEDLPFTESGLIPDIVFNPHGFPSRMTIAMMIETMAGKGAAIHGNVYDATPFRF 943
            ||||:.......|||||.:.|:.||:|.||||||||||:...:|.:..|...:.|..:..|.|..
Mosquito   905 GQKGVTGLIVEQEDLPFNDYGMSPDMVMNPHGFPSRMTVGKTLELLGSKAGVLEGKFHYGTAFGG 969

  Fly   944 SEENTAIDYFGKMLEAGGYNYYGTERLYSGVDGREMTADIFFGVVHYQRLRHMVFDKWQVRSTGA 1008
            |:.:...|    .|...|:||.|.:..|||:.|..:...|:.|.|:||:|:|||.||...|:.|.
Mosquito   970 SKCSDLQD----ELFNHGFNYLGKDVFYSGITGEPLEVYIYSGPVYYQKLKHMVQDKMHARARGP 1030

  Fly  1009 VEARTHQPIKGRKRGGGVRFGEMERDALISHGAAFLLQDRLFHNSDKTHTLVCHKCGSILAPLQR 1073
            ....|.||.:||.|.||:|.||||||.|||:||:.|:.:||..:||.....||:.||.:
Mosquito  1031 RAVLTRQPTQGRSREGGLRLGEMERDCLISYGASMLIMERLMISSDAFDVDVCNVCGRL------ 1089

  Fly  1074 IVKRNETGGLSSQPDTCRLCGDNSSVSMIEIPFSFKYLVTELSSVNINARFKL 1126
                       :....|..|..::|||.|.:|::.|.|..||:|:||..|.||
Mosquito  1090 -----------AYSSWCHNCRSSASVSTISMPYACKLLFQELTSMNIVPRLKL 1131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1B	NP_476708.1	RNA_pol_B_RPB2	35..1125	CDD:238353	320/1187 (27%)
		RNA_pol_Rpa2_4	564..619	CDD:462028	12/63 (19%)
RpIII128	XP_061510195.1	None