Protein Alignment RpI135 and polr2b

DIOPT Version :9

• Sequence 1: NP_476708.1
• Gene: RpI135 / 33210
• FlyBaseID: FBgn0003278
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_001019632.2
• Gene: polr2b / 100149268
• ZFINID: ZDB-GENE-041008-1
• Length: 1174
• Species: Danio rerio
• Alignment Length: 1237
• Identity: 339/1237 - (27%)
• Similarity: 550/1237 - (44%)
• Gaps: 263/1237 - (21%)

  Fly    40 VDSFDEML------------TVGLDNSAKHMIPNHWLSPAGE-----KISMKVESIWIAKPK--- 84
            :|||||.:            .:.|...|:|        .:||     :..:|.|.|:::||.
Zfish    44 LDSFDEFIQMSVQRIVEDAPPIDLQAEAQH--------TSGEVEEPPRYLLKFEQIYLSKPTHWE 100

  Fly    85 ---VPQDVIDVRTREIYPTDSRQLHVSYSGMCSVRLGWSV--NGV-------QKTPINMDLGEVP 137
               .|..::        |.::|..:::||....|.:..::  :|.       |||.|    |::|
Zfish   101 RDGAPSPMM--------PNEARLRNLTYSAPLYVDITKTIIKDGEEQQQTQHQKTFI----GKIP 153

  Fly   138 IMLRSKACNLGQATPEEMVKHGEHDSEWGGIFVIRGNEK--IVRMLIMTRRNHPICVKRSSWKDR 200
            |||||..|.|...|..::.:..|...:.||.|:|.|:||  |.:..:.|...:....|.|.:...
Zfish   154 IMLRSTYCLLSGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYT 218

  Fly   201 GQNFSDLGMLVQTVREDESSLSNVVHYLNNGTAKFMFSH--VKRLSY----VPVCLILKCLMDYT 259
            |:..|   .|..:.|...:...:::.....|..|.....  |..|.|    ||:.::.:.|...:
Zfish   219 GECRS---CLENSSRPTSTIWVSMMARGGQGVKKSAIGQRIVSTLPYIRQEVPIIIVFRALGFVS 280

  Fly   260 DEEIYNRLVQGYESDQYYVSCVQAMLRE---VQNENVYTHAQCKSFIGNLFRARFPEVPEWQPDD 321
            |.:|...::..:: |...:..|:..|.|   :|.:||     ..:|||:  |...|.|.:.:...
Zfish   281 DRDILEHIIYDFD-DPEMMEMVKPSLDEAFVIQEQNV-----ALNFIGS--RGAKPGVTKERRIK 337

  Fly   322 DVTDFILRERVMIHLDTYE----DKFQLIVFMIQKLFQCAQGKYKVENVDSAMMQEVLLPGHLYQ 382
            ...: :|::.|:.|:...:    .|...:.:|:.:|...|.|:.::::.|....:.:.|.|.|..
Zfish   338 YAKE-VLQKEVLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLA 401

  Fly   383 KYLSERVESWVSQVRRCLQKKL-TSPDALVTSAVMTQCMRQAGGVGRAIESFLATGNIA------ 440
            .......::.:.::|...||.: ...|..:..|:.|:.      :...::..|||||..
Zfish   402 FLFRGMFKNLLKEIRIYAQKFIDRGKDFNLELAIKTRI------ISDGLKYSLATGNWGDVKKAH 460

  Fly   441 -SRTGLGLMQNSGLVIMAENINRMRY---MSHFRAIH----RGSYFTTMRTTEARQLLPDAWGFI 497
             :|.|           :::.:||:.:   :||.|.::    |..     :..:.|||....||.:
Zfish   461 QARAG-----------VSQVLNRLTFASTLSHLRRVNSPIGRDG-----KLAKPRQLHNTLWGMV 509

  Fly   498 CPVHTPDGTPCGLLNHLTLTCEISM--RPDP-----------KLVKAIPKHLIDMGMMPLSNRRY 549
            ||..||:|...||:.:|.|...||:  :|.|           .|.:..|..:.|...
Zfish   510 CPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATK-------- 566

  Fly   550 LGEKLYVVFLDGKHLGHIHQSEAEKIVDELRYGKIFGTLPQMMEI--GFIPFKKNGQFPGLYIAT 612
                   :|::|..:| ||: :.|::::.||      .|.:.|:|  ..:...::.:...:.|.|
Zfish   567 -------IFVNGCWVG-IHK-DPEQLMNTLR------KLRRQMDIIVSEVSMIRDIREREIRIYT 616

  Fly   613 GPARMMRPVW-----------------------NLKWKR------VEYIGTLEQLYMEIAIDAKE 648
            ...|:.||:.                       |..|:.      ||||.|||:..:.:|:...:
Zfish   617 DAGRICRPLLIVEKQKLLLKRRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDD 681

  Fly   649 M------YPDFTTHLELAKTHFMSNLANLIPMPDYNQSPRNMYQCQMGKQTMGTPCLNWPKQAAN 707
            :      |....||.|:..:..:...|::||.||:||||||.||..||||.||....|:..:...
Zfish   682 LQEKGVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDT 746

  Fly   708 KLYRLQTPGTPLFRPVHYDNIQLDDFAMGTNAIVAVISYTGYDMEDAMIINKAAYERGFAYGSIY 772
            ..:.|..|..||......:.::..:...|.|:|||:.|||||:.||::|:|::|.:||| :.|::
Zfish   747 LAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGF-FRSVF 810

  Fly   773 KTKFLTLDKKSSY---------------FARHPHMPELIKHLDTDGLPHPGSKLSYGSPLYCYFD 822
            ...:...:.|..:               ..||    .:...||.|||..||.::|
Zfish   811 YRSYKEQESKKGFDQEEIFEKPTRETCQGMRH----AIYDKLDDDGLIAPGVRVS---------- 861

  Fly   823 GE-VATYKVVKMDE-------------KEDC----------IVESIRQLGSFDLSPKKMVAITLR 863
            || |...|.|.:.|             |.||          ||:.:  :.:.:....|...|.:|
Zfish   862 GEDVIIGKTVTLPENDDELDSTNRRYTKRDCSTFLRTSETGIVDQV--MVTLNQEGYKFCKIRVR 924

  Fly   864 VPRPATIGDKFASRAGQKGICSQKYPAEDLPFTESGLIPDIVFNPHGFPSRMTIAMMIETMAGKG 928
            ..|...||||||||.||||.|..:|..||:|||..|:.|||:.|||..|||||:..:||.:.||.
Zfish   925 SVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTVGHLIECLQGKV 989

  Fly   929 AAIHGNVYDATPFRFSEENTAIDY--FGKMLEAGGYNYYGTERLYSGVDGREMTADIFFGVVHYQ 991
            :|..|.:.|||||     |.|::.  ...:|...||:..|.|.||:|..||::|:.||.|..:||
Zfish   990 SANKGEIGDATPF-----NDAVNVQKVSNLLSEYGYHLRGNEVLYNGFTGRKLTSQIFVGPTYYQ 1049

  Fly   992 RLRHMVFDKWQVRSTGAVEARTHQPIKGRKRGGGVRFGEMERDALISHGAAFLLQDRLFHNSDKT 1056
            ||:|||.||...|:.|.|:....||::||.|.||:||||||||..|:||||..|::|||..||..
Zfish  1050 RLKHMVDDKIHSRARGPVQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLKERLFEASDPY 1114

  Fly  1057 HTLVCHKCGSILAPLQRIVKRNETGGLSSQPDTCRLCGDNSSVSMIEIPFSFKYLVTELSSVNIN 1121
            ...||:.||.:.....|           :....||.|.:.:.:|::.:|::.|.|..||.|::|.
Zfish  1115 QVHVCNLCGLMAIANTR-----------THTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIA 1168

  Fly  1122 AR 1123
            .|
Zfish  1169 PR 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RpI135	NP_476708.1	RpoB	34..1128	CDD:223163	339/1237 (27%)
		RNA_pol_B_RPB2	35..1125	CDD:238353	339/1237 (27%)
		RNA_pol_Rpa2_4	564..614	CDD:284335	11/51 (22%)
polr2b	NP_001019632.2	PRK08565	27..1172	CDD:236291	339/1237 (27%)
		RNA_pol_B_RPB2	39..1172	CDD:238353	339/1237 (27%)
		RNA_pol_Rpb2_4	567..629	CDD:282431	16/69 (23%)
		RNA_pol_Rpb2_5	653..700	CDD:282432	13/46 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920