DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment al and Pax4

DIOPT Version :9

Sequence 1:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_113987.1	Gene:	Pax4 / 83630	RGDID:	620433	Length:	349	Species:	Rattus norvegicus

Alignment Length:	195	Identity:	56/195 - (28%)
Similarity:	79/195 - (40%)	Gaps:	55/195 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 NSDCEADEYAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQN 135
            :|:|||..........|.||.|:..|.|.|||.|.|..|||...|.:||....|.|..::|||.|
  Rat   156 HSNCEAPRGPHPGTSHRNRTIFSPGQAEALEKEFQRGQYPDSVVRGKLAAATSLPEDTVRVWFSN 220

  Fly   136 RRAKWRKQEKVGPQSHPYNPYLPGGAATMQ----------------TVVGAALPP----NP-FTH 179
            ||||||:|||:     .:...:||.:..:.                :|..||||.    || |..
  Rat   221 RRAKWRRQEKL-----KWETQMPGASQDLMVPKDSPGIISAQQSPGSVPSAALPVLEQLNPSFCQ 280

  Fly   180 LGF--------------QLRKPFDAQH------AANLAAFRYPHLSAAPM---------IPSGYF 215
            |.:              ...:|:...|      :::...|.:|.|:..|:         .||.|:
  Rat   281 LCWGAVPDRCSSDTTSQACLQPYWECHSLLPVASSSYMEFAWPCLTTHPVHHLIGGPGQAPSTYY 345

Fly 216 215
Rat 346 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeobox	89..141	CDD:278475	26/51 (51%)
al	NP_722629.1	OAR	374..391	CDD:281777
Pax4	NP_113987.1	PAX	5..129	CDD:128645
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	8..64
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	83..131
		Homeobox	174..226	CDD:278475	26/51 (51%)
		Transcription repression	278..349		11/68 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910