Protein Alignment al and Pax4

DIOPT Version :10

• Sequence 1: NP_722629.1
• Gene: al / 33208
• FlyBaseID: FBgn0000061
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_113987.1
• Gene: Pax4 / 83630
• RGDID: 620433
• Length: 349
• Species: Rattus norvegicus
• Alignment Length: 195
• Identity: 56/195 - (28%)
• Similarity: 79/195 - (40%)
• Gaps: 55/195 - (28%)

  Fly    71 NSDCEADEYAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQN 135
            :|:|||..........|.||.|:..|.|.|||.|.|..|||...|.:||....|.|..::|||.|
  Rat   156 HSNCEAPRGPHPGTSHRNRTIFSPGQAEALEKEFQRGQYPDSVVRGKLAAATSLPEDTVRVWFSN 220

  Fly   136 RRAKWRKQEKVGPQSHPYNPYLPGGAATMQ----------------TVVGAALPP----NP-FTH 179
            ||||||:|||:     .:...:||.:..:.                :|..||||.    || |..
  Rat   221 RRAKWRRQEKL-----KWETQMPGASQDLMVPKDSPGIISAQQSPGSVPSAALPVLEQLNPSFCQ 280

  Fly   180 LGF--------------QLRKPFDAQH------AANLAAFRYPHLSAAPM---------IPSGYF 215
            |.:              ...:|:...|      :::...|.:|.|:..|:         .||.|:
  Rat   281 LCWGAVPDRCSSDTTSQACLQPYWECHSLLPVASSSYMEFAWPCLTTHPVHHLIGGPGQAPSTYY 345

  Fly   216  215
              Rat   346  345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeodomain	86..142	CDD:459649	28/55 (51%)
		OAR	374..391	CDD:461067
Pax4	NP_113987.1	PAX	5..129	CDD:128645
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	8..64
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	83..131
		Homeodomain	172..227	CDD:459649	28/54 (52%)
		Transcription repression	278..349		11/68 (16%)