Protein Alignment al and ALX1

DIOPT Version :9

• Sequence 1: NP_722629.1
• Gene: al / 33208
• FlyBaseID: FBgn0000061
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_008913.2
• Gene: ALX1 / 8092
• HGNCID: 1494
• Length: 326
• Species: Homo sapiens
• Alignment Length: 366
• Identity: 94/366 - (25%)
• Similarity: 121/366 - (33%)
• Gaps: 192/366 - (52%)

  Fly    65 SPVSDGNSDCEADEYAPK-------RKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKI 122
            |||.......|.||...|       .|:||:||||||.|||||||.|.:||||||:.||:||::.
Human   105 SPVKGMQEKGELDELGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRT 169

  Fly   123 GLTEARIQVWFQNRRAKWRKQEKVG------------------PQSHPY----NPYLPGGAATMQ 165
            .|||||:|||||||||||||:|:.|                  |::..|    |....|.|:...
Human   170 ELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNASGGS 234

  Fly   166 TVVGAALPPN------PFTHLGFQLRKPFDAQHAANLAAFRYPHLSAAPMIPSGY--FNQFQRAP 222
            .|....||.:      |::|                           :|...|.|  |:..|...
Human   235 VVTSCMLPRDTSSCMTPYSH---------------------------SPRTDSSYTGFSNHQNQF 272

  Fly   223 PHMLPHGMAGMYSPSSSF--QSLLANMTAVPRGTPLGKPPALLVGSPDLHSPNHMLASPPTSPAS 285
            .|:          |.::|  .|||                                    |...:
Human   273 SHV----------PLNNFFTDSLL------------------------------------TGATN 291

  Fly   286 GHASQHQQHPTAHPPPPQAPPQMPVGVQPAQLSPQHLVGIALTQQASSLSPTQTSPVALTLSHSP 350
            |||.:
Human   292 GHAFE------------------------------------------------------------ 296

  Fly   351 QRQLPPPSHQAPPPPPRAATPPE-DRRTSSIAALRLKAREH 390
                               |.|| :||:||||.||:||:||
Human   297 -------------------TKPEFERRSSSIAVLRMKAKEH 318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeobox	89..141	CDD:278475	39/51 (76%)
		OAR	374..391	CDD:281777	12/17 (71%)
ALX1	NP_008913.2	Homeobox	135..189	CDD:365835	40/53 (75%)
		Transactivation domain. /evidence=ECO:0000250|UniProtKB:Q63087	192..326		41/279 (15%)
		OAR	302..320	CDD:367680	12/17 (71%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	306..319		10/13 (77%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	147	1.000	Inparanoid score	I4418
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40292
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5874
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.100