DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment al and ESX1

DIOPT Version :9

Sequence 1:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_703149.1	Gene:	ESX1 / 80712	HGNCID:	14865	Length:	406	Species:	Homo sapiens

Alignment Length:	429	Identity:	117/429 - (27%)
Similarity:	153/429 - (35%)	Gaps:	136/429 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EEIKLEELPQEAKLAHPDAVVLVDRAPGSSAASAGAALTVSMSVSGGAPSGASGASGG------- 62
            ||:..|:|...:.:|....    |.....|....|.....::...|..||......||
Human    24 EEVNDEKLTVTSLMARGGE----DEENTRSKPEYGTEAENNVGTEGSVPSDDQDREGGGGHEPEQ 84

  Fly    63 --TNSPVS--------------------------DGNSDCEADEYA-----PKRKQRRYRTTFTS 94
              ...|::                          :|....|..:.|     |:||:|| ||.||.
Human    85 QQEEPPLTKPEQQQEEPPLLELKQEQEEPPQTTVEGPQPAEGPQTAEGPQPPERKRRR-RTAFTQ 148

  Fly    95 FQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQNRRAKWRKQEKV--------GPQSH 151
            |||:|||..|..:.||||..||.||.::.|||.|:|||||||||||::.::|        ...:|
Human   149 FQLQELENFFDESQYPDVVARERLAARLNLTEDRVQVWFQNRRAKWKRNQRVLMLRNTATADLAH 213

  Fly   152 PYNPYLPGGAATMQTVVGAALPPNPFTHLGFQLRKPFDAQHAANLAAFRYPHLSAAPMIPSGYFN 216
            |.:.:| |||    .....||.|....||..||.:|              |.|...||.|.
Human   214 PLDMFL-GGA----YYAAPALDPALCVHLVPQLPRP--------------PVLPVPPMPPR---- 255

  Fly   217 QFQRAPPHMLPHGMAGMYSPSSSFQSLLANMTAVPRGTPLGKPPALLVGSPDLHSPNHMLASPPT 281
                  |.|:|.......:|       :..|..||.|:.:...|           |...:|..|.
Human   256 ------PPMVPMPPRPPIAP-------MPPMAPVPPGSRMAPVP-----------PGPRMAPVPP 296

  Fly   282 SPASGHASQHQQHPTAHPPP-------PQAPPQMPV--GVQPAQLSPQHLVG--IALTQQASSLS 335
            .|           |.|..||       |..||..||  |...|::.|    |  :|.......::
Human   297 WP-----------PMAPVPPWPPMAPVPTGPPMAPVPPGPPMARVPP----GPPMARVPPGPPMA 346

  Fly   336 PTQTSPVALTLSHSPQRQLP--PPSHQAPPPPPRAATPP 372
            |....|        |...||  ||....||.||.|..||
Human   347 PLPPGP--------PMAPLPPGPPMAPLPPGPPMAPLPP 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeobox	89..141	CDD:278475	33/51 (65%)
al	NP_722629.1	OAR	374..391	CDD:281777
ESX1	NP_703149.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..142		16/112 (14%)
		Nuclear localization signal. /evidence=ECO:0000255	138..143		4/5 (80%)
		Homeobox	142..195	CDD:278475	34/53 (64%)
		15 X 9 AA tandem repeats of P-P-x-x-P-x-P-P-x	244..378		47/199 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..364		7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910