DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment al and pax8

DIOPT Version :9

Sequence 1:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	XP_001339893.5	Gene:	pax8 / 60637	ZFINID:	ZDB-GENE-001030-3	Length:	448	Species:	Danio rerio

Alignment Length:	342	Identity:	77/342 - (22%)
Similarity:	118/342 - (34%)	Gaps:	103/342 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LPQEAKLAHPDAVVLVDRA--PGSSAASAGAALTVSMS-VSGGAPSGASGASGGTNSPVSDGNSD 73
            ||.:.|...|...::...|  |..|..|.....|.|:: :.|...:.|.|..|       ..:||
Zfish   141 LPLDTKGLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGITQTTADGKRG-------HDDSD 198

  Fly    74 CEADEYA--------PKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKI-------- 122
            .|:..::        ..|||.|..    .|....|:..|.|.:..|.|::.:...::
Zfish   199 QESCRHSVDSQGSGGGARKQLRTE----HFPSAALDCGFERHYSSDSFSQSKAEQQLYPLALMNP 259

  Fly   123 GLTEARIQVWFQNRRAKWR----------------KQEKVGPQ--SHPYNPYLPGGAATMQTVVG 169
            ||.|.:.........|..:                ||| |.|:  |...:|::..|:|.:.  :.
Zfish   260 GLDEGKGASSISRNLAAHQGYAVVTEALQPLPLCLKQE-VSPEVNSLSPSPHIISGSAFLD--LS 321

  Fly   170 AALPPNP--------FTHL--GFQLRKPFDAQHAANLAAFRYPHLS-----AAPMIPSGYFNQFQ 219
            |...|:.        ..||  ||   ..| :.||.....|..|.|.     |:.|:| ||
Zfish   322 AISSPSSAPVASSCGSAHLSHGF---SSF-SHHAPVHGQFSSPSLMAGREVASSMLP-GY----- 376

  Fly   220 RAPPHMLPHGMAGMYSPSSSFQSLLANMTAVPR--GTPLGKPP------------ALLVGSPDLH 270
              ||| :|....|..|      |.:|.|.:.|.  |.....|.            :.::|||..:
Zfish   377 --PPH-IPTAQTGFSS------STIAGMVSAPEYTGQSYSHPAYSSYSEAWRFTNSSILGSPYYY 432

  Fly   271 SPNHMLASPPTSPASGH 287
            |.    |:.|..||:.:
Zfish   433 SS----ATRPPPPAAAY 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeobox	89..141	CDD:278475	10/59 (17%)
al	NP_722629.1	OAR	374..391	CDD:281777
pax8	XP_001339893.5	PAX	8..132	CDD:128645
pax8	XP_001339893.5	Pax2_C	343..437	CDD:289189	30/116 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910