DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment al and phox2bb

DIOPT Version :9

Sequence 1:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_001014818.1	Gene:	phox2bb / 544654	ZFINID:	ZDB-GENE-050407-3	Length:	284	Species:	Danio rerio

Alignment Length:	274	Identity:	93/274 - (33%)
Similarity:	121/274 - (44%)	Gaps:	70/274 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SSAASAGAALTVSMSVSG----------GAPSGASGASGGTNSPVSDGN-SDCEADEYA------ 80
            ||.|||.|..:.....||          ||.||....:.|:   .|.|. .|.::..||
Zfish    24 SSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSLTPGS---CSLGTLRDHQSSPYAAVPYKL 85

  Fly    81 --------PKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQNRR 137
                    .||||||.||||||.||:|||:.|:.|||||::||||||:||.|||||:||||||||
Zfish    86 FTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRR 150

  Fly   138 AKWRKQEK------------VGPQSHPYNPYLPGGAATMQTVVGAALP-PNPFTHLGFQLRKPFD 189
            ||:||||:            .|.:|...........||.....|...| |||.::.|
Zfish   151 AKFRKQERAAAAAAAAAKNGTGKKSDSREEDSKEAKATDPDSTGGPGPNPNPTSNCG-------- 207

  Fly   190 AQHAANLAAFRYPHLSAAPMIPSGYFNQFQRAPPHMLPHGMAGM--YSPSSSFQSLLANMTAVPR 252
                             .|....|..:.....|...:...:|||  .:|:..:.|....:|::|
Zfish   208 -----------------GPSPTGGQVSATGNGPVEQVKTSVAGMGPTAPTQGWASAPGTITSIP- 254

  Fly   253 GTPLGKPPALLVGS 266
             ..||.|.|.::.|
Zfish   255 -DSLGGPFASVLSS 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeobox	89..141	CDD:278475	40/51 (78%)
al	NP_722629.1	OAR	374..391	CDD:281777
phox2bb	NP_001014818.1	Homeobox	102..154	CDD:278475	40/51 (78%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910