Protein Alignment al and PITX1

DIOPT Version :10

• Sequence 1: NP_722629.1
• Gene: al / 33208
• FlyBaseID: FBgn0000061
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: XP_047273274.1
• Gene: PITX1 / 5307
• HGNCID: 9004
• Length: 348
• Species: Homo sapiens
• Alignment Length: 411
• Identity: 108/411 - (26%)
• Similarity: 153/411 - (37%)
• Gaps: 153/411 - (37%)

  Fly     7 IKLEELPQEAK--------------LAHPDAVVLVD-RAPGSSAASAGAALTVSMSVSGGAPSGA 56
            :.||.||:..:              ||.|     .| |.|..::||..:...:.....||.|.|.
Human    42 MSLERLPEGLRPPPPPPHDMGPAFHLARP-----ADPREPLENSASESSDTELPEKERGGEPKGP 101

  Fly    57 --SGASGGTNSPVSDGNSDC-EADEYAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREEL 118
              ||| |||.         | .||:.|.|:||||.||.|||.||:|||..|.|..|||:..|||:
Human   102 EDSGA-GGTG---------CGGADDPAKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEI 156

  Fly   119 AMKIGLTEARIQVWFQNRRAKWRKQEKVGPQSHPYNPYLPGGAATMQTVVGAALPPNPFTHLGFQ 183
            |:...|||.|::|||:||||||||:|:..........|:|..:..:|
Human   157 AVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGYVPQFSGLVQ------------------ 203

  Fly   184 LRKPFDAQHAANLAAFRYPHLSAAPMIPS-------GYFNQFQRAPPHMLPHGMAGMYSPSSSFQ 241
               |::..:|   |.:.|.:.:|..:.|:       .:||.       |.|.....|:|..||..
Human   204 ---PYEDVYA---AGYSYNNWAAKSLAPAPLSTKSFTFFNS-------MSPLSSQSMFSAPSSIS 255

  Fly   242 SLLANMTAVPRGTPLGKPPALLVGSPD--LHSPNHMLASPPTSPASGHASQHQQHPTAHPPPPQA 304
            |:.         .|....|..:.|.|:  |::.|::..|...|..|
Human   256 SMT---------MPSSMGPGAVPGMPNSGLNNINNLTGSSLNSAMS------------------- 292

  Fly   305 PPQMPVGVQPAQLSPQHLVGIALTQQASSLSPTQTSPVALTLSHSPQRQLPPPSHQAPPPPPRAA 369
            |...|.|                         |..||.::.
Human   293 PGACPYG-------------------------TPASPYSVY------------------------ 308

  Fly   370 TPPEDRRTSSIAALRLKAREH 390
               .|...||:|:||||:::|
Human   309 ---RDTCNSSLASLRLKSKQH 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeodomain	86..142	CDD:459649	34/55 (62%)
		OAR	374..391	CDD:461067	9/17 (53%)
PITX1	XP_047273274.1	Homeodomain	124..180	CDD:459649	34/55 (62%)
		OAR	310..327	CDD:461067	9/17 (53%)