DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment al and PAX7

DIOPT Version :9

Sequence 1:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_002575.1	Gene:	PAX7 / 5081	HGNCID:	8621	Length:	520	Species:	Homo sapiens

Alignment Length:	361	Identity:	114/361 - (31%)
Similarity:	150/361 - (41%)	Gaps:	99/361 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 APSGASGASGGTNSPVSDGNSDCEADEYAP-KRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTR 115
            |.....|..|...:.:.:| ||.|::...| ||||||.|||||:.|||||||||.||||||::||
Human   184 AKHSIDGILGDKGNRLDEG-SDVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFERTHYPDIYTR 247

  Fly   116 EELAMKIGLTEARIQVWFQNRRAKWRKQEKVGPQSHPYNPYLPGG--AATMQTVVGAALPPN--P 176
            ||||.:..|||||:||||.||||:||||.... |...:|..||||  ...|.|:....||.:  |
Human   248 EELAQRTKLTEARVQVWFSNRRARWRKQAGAN-QLAAFNHLLPGGFPPTGMPTLPPYQLPDSTYP 311

  Fly   177 FTHL----GFQLRKPF----DAQHAANLAAFRYPHLSAAPMIPSGYFNQFQRAPPHMLPHGMAGM 233
            .|.:    |..:.:|.    ...|...|||     .:||....|.|                 |.
Human   312 TTTISQDGGSTVHRPQPLPPSTMHQGGLAA-----AAAAADTSSAY-----------------GA 354

  Fly   234 YSPSSSFQSLLANMTAVPRGTPLGKPPALLVGSPDLHSPNHMLASPPTSPASGHASQHQQHPTAH 298
            ....||:.....|..|          |:           |||  :|.::..|........:|:|.
Human   355 RHSFSSYSDSFMNPAA----------PS-----------NHM--NPVSNGLSPQVMSILGNPSAV 396

  Fly   299 PPPPQAPPQMPVGVQPAQLSPQH-------LVGIALTQQASSLSPTQTSPVAL-----TLSHSPQ 351
            ||.|||         ...:||.|       .:..:.:|:|.|:.|..:.|.:.     |.|.:..
Human   397 PPQPQA---------DFSISPLHGGLDSATSISASCSQRADSIKPGDSLPTSQAYCPPTYSTTGY 452

  Fly   352 RQLPPPSHQ------------------APPPPPRAA 369
            ...|...:|                  .|.|.|||:
Human   453 SVDPVAGYQYGQYGQSECLVPWASPVPIPSPTPRAS 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeobox	89..141	CDD:278475	39/51 (76%)
al	NP_722629.1	OAR	374..391	CDD:281777
PAX7	NP_002575.1	paired box domain	34..164
		PAX	34..163	CDD:238076
		octapeptide	86..93
		paired homeodomain	217..275		44/57 (77%)
		Homeobox	220..273	CDD:278475	39/52 (75%)
		Pax7	347..385	CDD:289156	13/77 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..409		8/28 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910