Protein Alignment al and PAX4

DIOPT Version :10

• Sequence 1: NP_722629.1
• Gene: al / 33208
• FlyBaseID: FBgn0000061
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_001353039.1
• Gene: PAX4 / 5078
• HGNCID: 8618
• Length: 351
• Species: Homo sapiens
• Alignment Length: 309
• Identity: 75/309 - (24%)
• Similarity: 99/309 - (32%)
• Gaps: 127/309 - (41%)

  Fly    33 SSAASAGAALTVSMSVSGGAPSGASGASGGTNSPVSDGNSDCEADEYAPKRKQRRYRTTFTSFQL 97
            |.|..|.|.||         |...|....||:....                 .|.||.|:..|.
Human   144 SPAVLAPAVLT---------PHSGSETPRGTHPGTG-----------------HRNRTIFSPSQA 182

  Fly    98 EELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQNRRAKWRKQEKVGPQSHPYNPYLPGGAA 162
            |.|||.|.|..|||...|.:||....|.|..::|||.|||||||:|||:     .:...|||.:.
Human   183 EALEKEFQRGQYPDSVARGKLATATSLPEDTVRVWFSNRRAKWRRQEKL-----KWEMQLPGASQ 242

  Fly   163 TMQTVVGAALPPNPFTHLGFQLRKPFDAQHAANLAAFRYPHLSAAPMIPSGYFNQFQRAPPHMLP 227
            .: ||                                                       |.:.|
Human   243 GL-TV-------------------------------------------------------PRVAP 251

  Fly   228 HGMAGMYSPSSSFQSLLANMTAVPRGTPLGKPPALLVGSPDLH------SPNHMLA-SPPTS--- 282
            ..::...||.|      ....|:|...|||         |..:      :|...|: :||.:
Human   252 GIISAQQSPGS------VPTAALPALEPLG---------PSCYQLCWATAPERCLSDTPPKACLK 301

  Fly   283 PASGHASQHQQHPTAHPPPPQAPPQMPVGV--QPAQLSPQHLVGIALTQ 329
            |..||.            ||| |..:..|:  .|...|..||..::.:|
Human   302 PCWGHL------------PPQ-PNSLDSGLLCLPCPSSHCHLASLSGSQ 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeodomain	86..142	CDD:459649	28/55 (51%)
		OAR	374..391	CDD:461067
PAX4	NP_001353039.1	PAX	5..129	CDD:128645
		Homeodomain	172..227	CDD:459649	28/54 (52%)