Protein Alignment al and OTX1

DIOPT Version :10

• Sequence 1: NP_722629.1
• Gene: al / 33208
• FlyBaseID: FBgn0000061
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_055377.1
• Gene: OTX1 / 5013
• HGNCID: 8521
• Length: 354
• Species: Homo sapiens
• Alignment Length: 286
• Identity: 87/286 - (30%)
• Similarity: 114/286 - (39%)
• Gaps: 90/286 - (31%)

  Fly    80 APKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQNRRAKWRKQE 144
            |..|||||.|||||..||:.||..|::|.|||:|.|||:|:||.|.|:|:||||:|||||.|:|:
Human    33 ATPRKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQ 97

  Fly   145 KVG------PQSHPYNP------------YLP--------------GGAATMQTVVGAALPPNPF 177
            :.|      |.....:|            :.|              ..:|.......|.|..||.
Human    98 QSGSGTKSRPAKKKSSPVRESSGSESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPV 162

  Fly   178 -------THLGFQLRKPFDAQHAANLAAFRYPHLSAAPMIPSGYFNQFQR---------APPHML 226
                   |.....:..|......:..|:...|...|||...|    ..||         |..:.:
Human   163 AAASSLSTPAASSIWSPASISPGSAPASVSVPEPLAAPSNTS----CMQRSVAAGAATAAASYPM 223

  Fly   227 PHGMAGMY-----SPSSSF------QSLLANMTAVPRGTPLGKPPALLVGSPDLHSPNHMLASPP 280
            .:|..|.|     :||||:      .|.||.|                      ||.:|.....|
Human   224 SYGQGGSYGQGYPTPSSSYFGGVDCSSYLAPM----------------------HSHHHPHQLSP 266

  Fly   281 TSPAS--GHASQHQQHPTAHPPPPQA 304
            .:|:|  ||   |..||.||.|..|:
Human   267 MAPSSMAGH---HHHHPHAHHPLSQS 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeodomain	86..142	CDD:459649	35/55 (64%)
		OAR	374..391	CDD:461067
OTX1	NP_055377.1	Homeodomain	39..95	CDD:459649	35/55 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..146		8/54 (15%)
		TF_Otx	178..274	CDD:427350	27/121 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..305		14/36 (39%)