DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment al and PHOX2A

DIOPT Version :9

Sequence 1:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_005160.2	Gene:	PHOX2A / 401	HGNCID:	691	Length:	284	Species:	Homo sapiens

Alignment Length:	316	Identity:	97/316 - (30%)
Similarity:	119/316 - (37%)	Gaps:	120/316 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SMSVSGGAPSGASGASGGTN-SPVSD------------GNSDC---------------------- 74
            :|..|.....||....||.. ||:..            |:|:|
Human    15 AMEASAYGDFGACSQPGGFQYSPLRPAFPAAGPPCPALGSSNCALGALRDHQPAPYSAVPYKFFP 79

  Fly    75 EADEYAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQNRRAK 139
            |......||||||.||||||.||:|||:.|:.|||||::||||||:||.|||||:||||||||||
Human    80 EPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAK 144

  Fly   140 WRKQEKVGPQSHPYNPYLPGGAATMQTVVGAA------------------------------LPP 174
            :||||:               ||:.:...|||                              |||
Human   145 FRKQER---------------AASAKGAAGAAGAKKGEARCSSEDDDSKESTCSPTPDSTASLPP 194

  Fly   175 NPFTHLGFQLRKPFDAQHAANLAAFRYPHLSAAPMIPSGYFNQFQRAPPHMLPHGMAGMYSPSSS 239
            .|                |..||:   |.||.:|                 ||..:.....|...
Human   195 PP----------------APGLAS---PRLSPSP-----------------LPVALGSGPGPGPG 223

  Fly   240 FQSLLANMTAVPRGTPLGKPPALLVGSPDLHSPNHMLASPPTSPASGHASQHQQHP 295
            .|.|...:.|...|...|.|.|   |:.:|........|.| .|.||..|...:.|
Human   224 PQPLKGALWAGVAGGGGGGPGA---GAAELLKAWQPAESGP-GPFSGVLSSFHRKP 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeobox	89..141	CDD:278475	40/51 (78%)
al	NP_722629.1	OAR	374..391	CDD:281777
PHOX2A	NP_005160.2	Homeobox	94..147	CDD:365835	40/52 (77%)
PHOX2A	NP_005160.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..284		39/186 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910