DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment al and arxa

DIOPT Version :9

Sequence 1:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_571459.1	Gene:	arxa / 30657	ZFINID:	ZDB-GENE-990415-15	Length:	453	Species:	Danio rerio

Alignment Length:	412	Identity:	138/412 - (33%)
Similarity:	177/412 - (42%)	Gaps:	131/412 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GISEEIKLEELPQEAKLAHPDAVVLVDRAPGSSAASAGAALTVSMSVSGGAPSGASGASGGTNSP 66
            |.|.|...:||.:.:.|...:.|| .:.|.|.::.|               |....  |...:..
Zfish   144 GQSPEHMAQELVELSTLKFEEDVV-KEEACGDNSLS---------------PKDEE--SLHNDGD 190

  Fly    67 VSDG-NSDC-----EADEYAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLT 125
            |.|| :|.|     :::|...|||||||||||||:||||||:||.:||||||||||||||::.||
Zfish   191 VKDGEDSVCLSAGSDSEEGMLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLT 255

  Fly   126 EARIQVWFQNRRAKWRKQEKVGPQSHPYNPYLPGGAATMQT----VVGAALPPNPFTHLGFQLRK 186
            |||:|||||||||||||:||.|.|:||.....||..|....    :.|...||:|...|.
Zfish   256 EARVQVWFQNRRAKWRKREKAGVQAHPTGLPFPGPLAAAHPLSHYLEGGPFPPHPHPALE----- 315

  Fly   187 PFDAQHAANLAAFRYPHLSAAPMIPSGYFNQFQRAPPHMLPHGMAGMYSPSSSFQSLLANMTAVP 251
              .|..||..||..:|.|                |||            |:||         |:|
Zfish   316 --SAWTAAAAAAAAFPGL----------------APP------------PNSS---------ALP 341

  Fly   252 RGTPLGKPPALLVGSPDLHSPNHMLASPPTSPASGHASQHQQHPTAHPPPPQAPPQMPVGVQPAQ 316
            ..||||....|                         .:...:||.
Zfish   342 PATPLGLGTFL-------------------------GTAMFRHPA-------------------- 361

  Fly   317 LSPQHLVGIALTQQASSLSPTQTSPVALTLSHSPQRQLPP------PSHQAPPPPPRAATPPEDR 375
                 .:|....:..||:.|..::..|..|.   ::..||      ||...|.||..:::...||
Zfish   362 -----FIGPTFGRLFSSMGPLTSASTAAALL---RQTAPPVESPVQPSAALPEPPSSSSSTAADR 418

  Fly   376 RTSSIAALRLKAREHELKLELL 397
            |.||||||||||:||..:|..|
Zfish   419 RASSIAALRLKAKEHSAQLTQL 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeobox	89..141	CDD:278475	43/51 (84%)
al	NP_722629.1	OAR	374..391	CDD:281777	14/16 (88%)
arxa	NP_571459.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..75
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..149		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..212		11/58 (19%)
		Homeobox	219..271	CDD:278475	43/51 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..418		7/27 (26%)
		OAR	417..434	CDD:281777	14/16 (88%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	421..434		11/12 (92%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	110	1.000	Domainoid score	I6248
eggNOG	1	0.900	-	-		E33208_3BSUU
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26023
orthoMCL	1	0.900	-	-		OOG6_108797
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5874
SonicParanoid	1	1.000	-	-		X3639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.850