DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment al and pax3a

DIOPT Version :9

Sequence 1:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_571352.1	Gene:	pax3a / 30532	ZFINID:	ZDB-GENE-980526-52	Length:	509	Species:	Danio rerio

Alignment Length:	352	Identity:	106/352 - (30%)
Similarity:	134/352 - (38%)	Gaps:	118/352 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 GTNSPVSDGNSDCEADEYAP-KRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLT 125
            |..|..||..||.:::...| ||||||.|||||:.||||||:||.||||||::||||||.:..||
Zfish   196 GDRSSHSDEGSDVDSEPGLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLT 260

  Fly   126 EARIQVWFQNRRAKWRKQEKVGPQSHPYNPYLPGGAATMQTVVGAALPPNPFTHLGFQLRKPFDA 190
            |||:||||.||||:||||.... |...:|..:|||           .||:..:.|     :|:
Zfish   261 EARVQVWFSNRRARWRKQAGAN-QLMAFNHLIPGG-----------FPPSAMSSL-----QPY-- 306

  Fly   191 QHAANLAAFRYPHLSAA-------------PMIP------------------------------S 212
                .||...||..|.:             |:.|                              |
Zfish   307 ----QLADSPYPPSSISQVSEQPSTVHRPQPLPPTSVHQSGLGSGPGAQEGSSAYCLSSGRHGFS 367

  Fly   213 GYFNQFQRAPPHM----------LPHGMAGMYSPSSSFQSLLANMTAVPRGTPLGKPPALLVGSP 267
            ||.:.:..||.|.          ||..:.|:.:|.           |||
Zfish   368 GYSDGYVAAPGHANPVNPSISNGLPSQVMGLLNPG-----------AVP---------------- 405

  Fly   268 DLHSPNHMLASPPTS---------PASGHASQHQQHPTAHPPPPQAPPQM---PVGVQPAQLSPQ 320
              |.|....|..|.:         |||.|:||..:.....|..|..|...   |........|..
Zfish   406 --HQPQSDFALSPLTGGLEPSTGMPASCHSSQRLEALPGLPSMPALPSSQSYCPSSYSSPGYSVD 468

  Fly   321 HLVGIALTQQASSLSPTQTSPVALTLS 347
            |:.....:|...|...|.|......||
Zfish   469 HVASYQYSQYGQSKVNTSTVTTVERLS 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeobox	89..141	CDD:278475	38/51 (75%)
al	NP_722629.1	OAR	374..391	CDD:281777
pax3a	NP_571352.1	PAX	34..159	CDD:128645
		Homeobox	223..276	CDD:278475	38/52 (73%)
		Pax7	350..394	CDD:289156	8/43 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910