DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment al and pax2a

DIOPT Version :9

Sequence 1:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	XP_021336168.1	Gene:	pax2a / 30425	ZFINID:	ZDB-GENE-990415-8	Length:	519	Species:	Danio rerio

Alignment Length:	386	Identity:	94/386 - (24%)
Similarity:	127/386 - (32%)	Gaps:	144/386 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 HPDAVVLVDRAPGSSAASAGAAL--------TVSMSVSGGAPSGAS-GASGGTNSPV-------- 67
            ||.:     ...|:..::||..:        |::.|.:...||.|| ..|..:|.||
Zfish   158 HPSS-----DGTGTPLSTAGHTIGDLESTPYTLTYSCALSVPSTASPPVSSASNDPVGSYSINGI 217

  Fly    68 --------------------------------SDG---NSDCEADEYAPKRKQRRYRTTFTSFQL 97
                                            |||   |||.:....:.::..|  ...||..||
Zfish   218 LGIPRSNGEKRKRDDVLWSGNHLDGRKIGYYGSDGSGPNSDSQGSVESLRKHLR--ADAFTQQQL 280

  Fly    98 EELEKAFSRTHYPDVF-TREEL-----------AMKIGLTEARIQ-------------------V 131
            |.|::.|.|..||||| |.|.:           |:..||.|.:..                   |
Zfish   281 EALDRVFERPSYPDVFPTSEHIKPEQANEYSLPALNPGLDEVKPSLSTSVSSDLGSSVSQSYPVV 345

  Fly   132 WFQNRRAKWRKQEKVGPQSHPYNPYLPGGAATMQTVVGAA--LPPNPFTHLGFQLRKP---FDAQ 191
            ...:..:...|||   |......|:.|...|    |.|.|  ||..|  .:......|   ..|.
Zfish   346 TESHSSSMCVKQE---PHEASLAPFTPSSLA----VSGLAELLPLQP--SVSVDASTPCYGAYAH 401

  Fly   192 HAANLAAFRYPHLSAAPMIPS----GYFNQFQRAPPHMLPHGMAGMYSPSSSFQSLLANMTAVP- 251
            ||.:...:...|:.|...:.|    ||       |||:.|.|. |.| |:|:    ||.|  ||
Zfish   402 HAPSYCQYTSQHIIAGREMASTTLPGY-------PPHVPPTGQ-GSY-PTST----LAGM--VPG 451

  Fly   252 ---RGTPLGKP-------------PALLVGSPDLHSPNHMLASPPTSPASGHAS--QHQQH 294
               .|.|...|             ||||:..|.  :|...|...|.:..|.|.|  :.|.|
Zfish   452 SDFSGNPYSHPQYTTYNEAWRFSNPALLMPHPG--APGLPLLPLPMTATSYHRSPVKLQDH 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeobox	89..141	CDD:278475	20/82 (24%)
al	NP_722629.1	OAR	374..391	CDD:281777
pax2a	XP_021336168.1	PAX	19..150	CDD:128645
pax2a	XP_021336168.1	Pax2_C	391..500	CDD:315141	34/125 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910