DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment al and ALX3

DIOPT Version :9

Sequence 1:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_006483.2	Gene:	ALX3 / 257	HGNCID:	449	Length:	343	Species:	Homo sapiens

Alignment Length:	311	Identity:	101/311 - (32%)
Similarity:	135/311 - (43%)	Gaps:	91/311 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LPQEAKLAHPDAVVLVDRAPG----------------SSAASAGAALTVSMSVSGG---APSGAS 57
            ||:.||   |.|..|.|..||                ...:.|.:...:.:...||   .||...
Human    61 LPEPAK---PPAKYLQDLGPGPALNGGHFYEGPAEAEEKTSKAASFPQLPLDCRGGPRDGPSNLQ 122

  Fly    58 GASG----GTNSPVSDGNSDCEADEYAP-KRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREE 117
            |:.|    ..:.|:|.|..|  :.|.|. |.|:||.||||::||||||||.|.:||||||:.||:
Human   123 GSPGPCLASLHLPLSPGLPD--SMELAKNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQ 185

  Fly   118 LAMKIGLTEARIQVWFQNRRAKWRKQEKVGPQSHPYNPYL------------------------- 157
            ||::..|||||:|||||||||||||:|:.|......||:.
Human   186 LALRTDLTEARVQVWFQNRRAKWRKRERYGKIQEGRNPFTAAYDISVLPRTDSHPQLQNSLWASP 250

  Fly   158 ----PGGAATMQTVVGAALPPNPFTHLGFQLRKPFDAQHAANLAAFRYPHLSAA-PMIPS--GYF 215
                |||..    :|.....|:|       ...|:...|.:.......|..||| |.|.|  |:
Human   251 GSGSPGGPC----LVSPEGIPSP-------CMSPYSHPHGSVAGFMGVPAPSAAHPGIYSIHGF- 303

  Fly   216 NQFQRAPPHMLPHGMAGMYSPSS--SFQS-LLANMTAVPRGTPLGKPPALL 263
                  ||.:..|.    :.|||  .::| .|.::...|:     :||.||
Human   304 ------PPTLGGHS----FEPSSDGDYKSPSLVSLRVKPK-----EPPGLL 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeobox	89..141	CDD:278475	38/51 (75%)
al	NP_722629.1	OAR	374..391	CDD:281777
ALX3	NP_006483.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..104		11/45 (24%)
		PRK12323	<13..131	CDD:237057	17/72 (24%)
		Homeobox	157..210	CDD:365835	39/52 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	147	1.000	Inparanoid score	I4418
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5874
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.100