Protein Alignment al and ALX3

DIOPT Version :10

• Sequence 1: NP_722629.1
• Gene: al / 33208
• FlyBaseID: FBgn0000061
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_006483.2
• Gene: ALX3 / 257
• HGNCID: 449
• Length: 343
• Species: Homo sapiens
• Alignment Length: 311
• Identity: 101/311 - (32%)
• Similarity: 135/311 - (43%)
• Gaps: 91/311 - (29%)

  Fly    12 LPQEAKLAHPDAVVLVDRAPG----------------SSAASAGAALTVSMSVSGG---APSGAS 57
            ||:.||   |.|..|.|..||                ...:.|.:...:.:...||   .||...
Human    61 LPEPAK---PPAKYLQDLGPGPALNGGHFYEGPAEAEEKTSKAASFPQLPLDCRGGPRDGPSNLQ 122

  Fly    58 GASG----GTNSPVSDGNSDCEADEYAP-KRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREE 117
            |:.|    ..:.|:|.|..|  :.|.|. |.|:||.||||::||||||||.|.:||||||:.||:
Human   123 GSPGPCLASLHLPLSPGLPD--SMELAKNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQ 185

  Fly   118 LAMKIGLTEARIQVWFQNRRAKWRKQEKVGPQSHPYNPYL------------------------- 157
            ||::..|||||:|||||||||||||:|:.|......||:.
Human   186 LALRTDLTEARVQVWFQNRRAKWRKRERYGKIQEGRNPFTAAYDISVLPRTDSHPQLQNSLWASP 250

  Fly   158 ----PGGAATMQTVVGAALPPNPFTHLGFQLRKPFDAQHAANLAAFRYPHLSAA-PMIPS--GYF 215
                |||..    :|.....|:|       ...|:...|.:.......|..||| |.|.|  |:
Human   251 GSGSPGGPC----LVSPEGIPSP-------CMSPYSHPHGSVAGFMGVPAPSAAHPGIYSIHGF- 303

  Fly   216 NQFQRAPPHMLPHGMAGMYSPSS--SFQS-LLANMTAVPRGTPLGKPPALL 263
                  ||.:..|.    :.|||  .::| .|.::...|:     :||.||
Human   304 ------PPTLGGHS----FEPSSDGDYKSPSLVSLRVKPK-----EPPGLL 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeodomain	86..142	CDD:459649	41/55 (75%)
		OAR	374..391	CDD:461067
ALX3	NP_006483.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..104		11/45 (24%)
		PRK12323	<13..131	CDD:481241	17/72 (24%)
		Homeodomain	154..210	CDD:459649	41/55 (75%)