DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment al and Alx1

DIOPT Version :9

Sequence 1:NP_722629.1 Gene:al / 33208 FlyBaseID:FBgn0000061 Length:408 Species:Drosophila melanogaster
Sequence 2:NP_766141.1 Gene:Alx1 / 216285 MGIID:104621 Length:326 Species:Mus musculus


Alignment Length:366 Identity:94/366 - (25%)
Similarity:121/366 - (33%) Gaps:192/366 - (52%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 SPVSDGNSDCEADEYAPK-------RKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKI 122
            |||.......|.||...|       .|:||:||||||.|||||||.|.:||||||:.||:||::.
Mouse   105 SPVKGMPEKSELDELGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRT 169

  Fly   123 GLTEARIQVWFQNRRAKWRKQEKVG------------------PQSHPY----NPYLPGGAATMQ 165
            .|||||:|||||||||||||:|:.|                  |::..|    |....|.|:...
Mouse   170 ELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNASGGS 234

  Fly   166 TVVGAALPPN------PFTHLGFQLRKPFDAQHAANLAAFRYPHLSAAPMIPSGY--FNQFQRAP 222
            .|....||.:      |::|                           :|...|.|  |:..|...
Mouse   235 VVTSCMLPRDASSCMTPYSH---------------------------SPRTDSSYTGFSNHQNQF 272

  Fly   223 PHMLPHGMAGMYSPSSSF--QSLLANMTAVPRGTPLGKPPALLVGSPDLHSPNHMLASPPTSPAS 285
            .|:          |.::|  .|||                                    |...:
Mouse   273 SHV----------PLNNFFTDSLL------------------------------------TGATN 291

  Fly   286 GHASQHQQHPTAHPPPPQAPPQMPVGVQPAQLSPQHLVGIALTQQASSLSPTQTSPVALTLSHSP 350
            |||.:                                                            
Mouse   292 GHAFE------------------------------------------------------------ 296

  Fly   351 QRQLPPPSHQAPPPPPRAATPPE-DRRTSSIAALRLKAREH 390
                               |.|| :||:||||.||:||:||
Mouse   297 -------------------TKPEFERRSSSIAVLRMKAKEH 318

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alNP_722629.1 Homeobox 89..141 CDD:278475 39/51 (76%)
OAR 374..391 CDD:281777 12/17 (71%)
Alx1NP_766141.1 Homeobox 135..189 CDD:395001 40/53 (75%)
Transactivation domain. /evidence=ECO:0000250|UniProtKB:Q63087 192..326 41/279 (15%)
OAR 302..320 CDD:397759 12/17 (71%)
OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138 306..319 10/13 (77%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D454642at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42357
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24329
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5874
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.050

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