Protein Alignment al and Pax4

DIOPT Version :10

• Sequence 1: NP_722629.1
• Gene: al / 33208
• FlyBaseID: FBgn0000061
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_035168.1
• Gene: Pax4 / 18506
• MGIID: 97488
• Length: 349
• Species: Mus musculus
• Alignment Length: 222
• Identity: 67/222 - (30%)
• Similarity: 91/222 - (40%)
• Gaps: 34/222 - (15%)

  Fly    71 NSDCEADEYAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQN 135
            :|:|.|..........|.||.|:..|.|.|||.|.|..|||...|.:||....|.|..::|||.|
Mouse   156 HSNCGAPRGPHPGTSHRNRTIFSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSN 220

  Fly   136 RRAKWRKQEKVGPQSHPYNPYLPGGAATMQTVVGAALPPNPFTHLGFQLRKPFDAQHAANLAAFR 200
            ||||||:|||:     .:...|||.:..:      .:|.|....:..|       |...::.:..
Mouse   221 RRAKWRRQEKL-----KWEAQLPGASQDL------TVPKNSPGIISAQ-------QSPGSVPSAA 267

  Fly   201 YPHLSAAPMIPSGYFNQFQRAPPHMLPHGMA-GMYSPSSSFQSLLANMTAVPRGTPLGKPPALLV 264
            .|.|.  |:.||  |.|        |..|.| |..|..:|.|:.|..........|:.....:..
Mouse   268 LPVLE--PLSPS--FCQ--------LCCGTAPGRCSSDTSSQAYLQPYWDCQSLLPVASSSYVEF 320

  Fly   265 GSPDL--HSPNHMLASPPTSPASGHAS 289
            ..|.|  |..:|::..|...| |.|.|
Mouse   321 AWPCLTTHPVHHLIGGPGQVP-STHCS 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeodomain	86..142	CDD:459649	28/55 (51%)
		OAR	374..391	CDD:461067
Pax4	NP_035168.1	PAX	5..129	CDD:128645
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	8..64
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	83..131
		Homeodomain	172..227	CDD:459649	28/54 (52%)
		Transcription repression	278..349		20/78 (26%)