DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment al and Phox2a

DIOPT Version :9

Sequence 1:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_032913.1	Gene:	Phox2a / 11859	MGIID:	106633	Length:	280	Species:	Mus musculus

Alignment Length:	310	Identity:	94/310 - (30%)
Similarity:	115/310 - (37%)	Gaps:	112/310 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SMSVSGGAPSGASGASGGTN-SPVSD------------GNSDC---------------------- 74
            :|..|.....||....||.. ||:..            |:|:|
Mouse    15 AMEASAYGDFGACSQPGGFQYSPLRPAFPAAGPPCPALGSSNCALGALRDHQPAPYSAVPYKFFP 79

  Fly    75 EADEYAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQNRRAK 139
            |......||||||.||||||.||:|||:.|:.|||||::||||||:||.|||||:||||||||||
Mouse    80 EPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAK 144

  Fly   140 WRKQEKVGPQSHPYNPYLPGGAATMQTVVG-----------------------AALPPNPFTHLG 181
            :||||:.....        |.|.......|                       |:|||.|
Mouse   145 FRKQERAASAK--------GAAGATGAKKGEARCSSEDDDSKESTCSPTPDSTASLPPPP----- 196

  Fly   182 FQLRKPFDAQHAANLAAFRYPHLSAAPMIPSGYFNQFQRAPPHMLPHGMAGMYSPSSSFQSLLAN 246
                       |.:||:   |.||.:|                 ||..:.....|.....:|.|.
Mouse   197 -----------APSLAS---PRLSPSP-----------------LPAALGSGPGPQPLKGALWAG 230

  Fly   247 MTAVPRGTP-LGKPPALLVGSPDLHSPNHMLASPPTSPASGHASQHQQHP 295
            :.....|.| .|....|....|         |.|...|.||..|...:.|
Mouse   231 VAGGGGGGPGTGAAELLKAWQP---------AEPGPGPFSGVLSSFHRKP 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeobox	89..141	CDD:278475	40/51 (78%)
al	NP_722629.1	OAR	374..391	CDD:281777
Phox2a	NP_032913.1	Homeobox	94..147	CDD:395001	40/52 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..244		27/142 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..280		4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910