DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment al and Alx3

DIOPT Version :9

Sequence 1:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_031467.1	Gene:	Alx3 / 11694	MGIID:	1277097	Length:	343	Species:	Mus musculus

Alignment Length:	309	Identity:	101/309 - (32%)
Similarity:	135/309 - (43%)	Gaps:	87/309 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LPQEAKLAHPDAVVLVDRAPG----------------SSAASAGAALTVSMSVSGGAPSGASG-- 58
            ||:.||   |.|..|.|..||                ..|:.|.:...:.:...||...|.|.
Mouse    61 LPEPAK---PPAKYLQDLGPGPVLNGGHFYEGSAEAEEKASKAASFPQLPVDCRGGPRDGPSNVQ 122

  Fly    59 ASGG-----TNSPVSDGNSDCEADEYA-PKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREE 117
            ||.|     .:.|:|.|..|  :.|.| .|.|:||.||||::||||||||.|.:||||||:.||:
Mouse   123 ASPGPCLASLSVPLSPGLPD--SMELAKTKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQ 185

  Fly   118 LAMKIGLTEARIQVWFQNRRAKWRKQEKVGPQSHPYNPYL------------------------- 157
            ||::..|||||:|||||||||||||:|:.|......||:.
Mouse   186 LALRTDLTEARVQVWFQNRRAKWRKRERYGKMQEGRNPFTTAYDISVLPRTDSHPQLQNSLWPSP 250

  Fly   158 ----PGGAATMQTVVGAALP---PNPFTHLGFQLRKPFDAQHAANLAAFRYPHLSAAPMIPSGYF 215
                |||...|.       |   |:|       ...|:...| .|:|.|.  .:.|:|....|.:
Mouse   251 GSGSPGGPCLMS-------PEGIPSP-------CMSPYSHSH-GNVAGFM--GVPASPAAHPGIY 298

  Fly   216 NQFQRAPPHMLPHGMAGMYSPSSSFQS-LLANMTAVPRGTPLGKPPALL 263
            : ....||.:..|....  ||...::| .|.::...|:     :||.||
Mouse   299 S-IHGFPPALGGHSFEP--SPDGDYKSPSLVSLRMKPK-----EPPGLL 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
al	NP_722629.1	Homeobox	89..141	CDD:278475	38/51 (75%)
al	NP_722629.1	OAR	374..391	CDD:281777
Alx3	NP_031467.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..122		16/63 (25%)
		SP2	32..>141	CDD:281067	22/82 (27%)
		Homeobox	157..209	CDD:278475	38/51 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..343		10/38 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5874
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.050