DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ent1 and Slc29a1

DIOPT Version :9

Sequence 1:	NP_001259820.1	Gene:	Ent1 / 33207	FlyBaseID:	FBgn0031250	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_113872.1	Gene:	Slc29a1 / 63997	RGDID:	61899	Length:	457	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	146/462 - (31%)
Similarity:	243/462 - (52%)	Gaps:	58/462 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 SNEPESGRLFTYLVFYLLGIGTMTPWNFFVTAEDYWKYKFRNAS----INNTDLE--EELT---- 109
            |::|:......:|:|::||:||:.|||||:||..|:..:...:.    :.|...|  |.|.
  Rat     4 SHQPQDRYKAVWLIFFVLGLGTLLPWNFFITATQYFTSRLNTSQNISLVTNQSCESTEALADPSV 68

  Fly   110 --PLQKS----FTCDLALTATISGTTFLLLNAIFGHHVSLRTKMLGTLWMILILFGVTTGFVEIN 168
              |.:.|    |...:.|.|.:....|..||:.....||...::||:|..||::|.||...|::.
  Rat    69 SLPARSSLSAIFNNVMTLCAMLPLLIFTCLNSFLHQKVSQSLRILGSLLAILLVFLVTATLVKVQ 133

  Fly   169 TDTWQEQFFLITLIIVVLLNISAATMSGALYGVAGLFPSEFITAVVSGQALGGILTALAFILVLA 233
            .|..  .||:||:|.:||:|...|.:..:|:|:||:.|:.:...::|||.|.|..|::|.|..:|
  Rat   134 MDAL--SFFIITMIKIVLINSFGAILQASLFGLAGVLPANYTAPIMSGQGLAGFFTSVAMICAVA 196

  Fly   234 FDTGPNTTAFIFFIVGGVLILLCIVCYVILARKPFFRYYLE-----------------------G 275
            ..:..:.:||.:||....:::|.|:||:.|....|:|:||:                       |
  Rat   197 SGSKLSESAFGYFITACAVVILAILCYLALPWMEFYRHYLQLNLAGPAEQETKLDLISEGEEPRG 261

  Fly   276 GDKYKVI---RAVPSHNRNGSAEGLPLEPILRQVMSKIYLHAISLALLYTTTLSVYPAVTVLMQS 337
            |.:...:   .::|: |||.|         ::.::..|::.|:|:..::|.|:.::||||..::|
  Rat   262 GREESGVPGPNSLPA-NRNQS---------IKAILKSIWVLALSVCFIFTVTIGLFPAVTAEVES 316

  Fly   338 EY-GHSVWTDVYFLPVVNYLIFNCGDYFGRLFAGWMERPLNQNTSLLFIVV--RMAFVPLFLCSN 399
            .. |.|.|.:.||:||..:|.||..|:.||........| .|::..|.::|  |:.|:||.:..|
  Rat   317 SIAGTSPWKNCYFIPVACFLNFNVFDWLGRSLTAICMWP-GQDSRWLPVLVACRVVFIPLLMLCN 380

  Fly   400 SSEHSFLPVLVKHDYTFIAMMVMFALSNGYFTNILLIMAPKRVKQHEKELASSIMAAALSCGMAV 464
            ..:|.:||.|.|||..||..|..||.||||..::.:...||:||..|.|.|.:||:..|..|:|:
  Rat   381 VKQHHYLPSLFKHDVWFITFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGNIMSFFLCLGLAL 445

  Fly   465 GSLLSLV 471
            |::||.:
  Rat   446 GAVLSFL 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ent1	NP_001259820.1	Nucleoside_tran	69..476	CDD:301621	143/448 (32%)
Slc29a1	NP_113872.1	2a57	18..457	CDD:273352	143/448 (32%)
Slc29a1	NP_113872.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..275		2/19 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I3597
eggNOG	1	0.900	-	-		E1_KOG1479
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37985
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3336
OMA	1	1.010	-	-		QHG53699
OrthoDB	1	1.010	-	-		D318009at33208
OrthoFinder	1	1.000	-	-		FOG0000541
OrthoInspector	1	1.000	-	-		otm45393
orthoMCL	1	0.900	-	-		OOG6_100863
Panther	1	1.100	-	-	LDO	PTHR10332
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X296
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880