DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ent1 and Slc29a3

DIOPT Version :9

Sequence 1:	NP_001259820.1	Gene:	Ent1 / 33207	FlyBaseID:	FBgn0031250	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_853670.2	Gene:	Slc29a3 / 353307	RGDID:	727811	Length:	475	Species:	Rattus norvegicus

Alignment Length:	454	Identity:	133/454 - (29%)
Similarity:	226/454 - (49%)	Gaps:	22/454 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VPAFRPQDHHADEQCLMERQQDEVVLVSNEPESGRLFTYLVFYLLGIGTMTPWNFFVTAEDYWKY 92
            ||:.|   |.||::.|:.:..|........||......|::|:.||||.:.||||||||::||.:
  Rat    19 VPSNR---HEADQEALLGKPLDYPAPGLQRPEDRFNGAYIIFFCLGIGGLLPWNFFVTAKEYWAF 80

  Fly    93 KFRNASINNTDLEEELTPLQKSFTCDLALTATISGTTFLLLNAIFGHHVSLRTKMLGTLWMILIL 157
            |.||.|...:..:.|...:...|...||:.:|:....||:.|.:..:.:.:..::|.:|.:.|.:
  Rat    81 KLRNCSSPASGKDPEDADILNYFESYLAVASTVPSLLFLVANFLLVNRIRVHVRVLASLSVSLAI 145

  Fly   158 FGVTTGFVEINTDTWQEQFFLITLIIVVLLNISAATMSGALYGVAGLFPSEFITAVVSGQALGGI 222
            |.|....|.::|.:|...||.|.:..:.:::.|:...:.::||:.|.||.....|::||.|:||.
  Rat   146 FVVMAVLVRVDTSSWTRGFFSIAMACMAIISSSSTIFNSSVYGLTGSFPMRNAQALISGGAMGGT 210

  Fly   223 LTALAFILVLAFDTGPNTTAFIFFIVGGVLILLCIVCYVILARKPFFRYYLEGGDKYKVIRAVPS 287
            ::|:|.::.||..:....:|..||:...|.:.||:..|::|.:..:.|||:.......|..:..|
  Rat   211 VSAVASLVDLAASSDVRDSALAFFLTAAVFLGLCVGLYLLLPQLEYARYYMRPVVPIHVFSSEDS 275

  Fly   288 HNRNGSAEGL-----------PLEPILRQVMSKIYLHAISLALLYTTTLSVYPAVTVLMQSEY-- 339
            ..|:..:...           ||.|||::....    ......||..|..::||::..:|..:
  Rat   276 PPRDAPSTSSVAPASRAVHTPPLGPILKKTAGL----GFCAVFLYFITALIFPAISTNIQPMHKG 336

  Fly   340 GHSVWTDVYFLPVVNYLIFNCGDYFGRLFAGWMERPLNQNTSL-LFIVVRMAFVPLFLCSNSSEH 403
            ..|.||..:::|:..:|:||..|..||....|::.|..::..| :..|.|:..|||||..|....
  Rat   337 TGSPWTSKFYVPLTVFLLFNFADLCGRQVTAWIQVPGPRSKLLPILAVSRVCLVPLFLLCNYQPR 401

  Fly   404 SFLP-VLVKHDYTFIAMMVMFALSNGYFTNILLIMAPKRVKQHEKELASSIMAAALSCGMAVGS 466
            |.|. ||.:.|...|....:..|||||.:.::|:..||.|.:...|..|.:|...:|.|:.:||
  Rat   402 SHLTLVLFQSDIYPILFTCLLGLSNGYLSTLVLMYGPKIVPRELAEATSVVMLFYMSLGLMLGS 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ent1	NP_001259820.1	Nucleoside_tran	69..476	CDD:301621	122/413 (30%)
Slc29a3	NP_853670.2	Nucleoside_tran	57..475	CDD:301621	122/413 (30%)
Slc29a3	NP_853670.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..291		2/18 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7492
eggNOG	1	0.900	-	-		E1_KOG1479
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53699
OrthoDB	1	1.010	-	-		D318009at33208
OrthoFinder	1	1.000	-	-		FOG0000541
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100863
Panther	1	1.100	-	-	O	PTHR10332
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X296
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.830