DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ent1 and SLC29A1

DIOPT Version :9

Sequence 1:	NP_001259820.1	Gene:	Ent1 / 33207	FlyBaseID:	FBgn0031250	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_011512643.1	Gene:	SLC29A1 / 2030	HGNCID:	11003	Length:	536	Species:	Homo sapiens

Alignment Length:	509	Identity:	157/509 - (30%)
Similarity:	260/509 - (51%)	Gaps:	48/509 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DTRRLVDALDEDDEILGTEGSFVPAFRPQDHHADE-----QCLMERQQDEVVL-VSNEPESGRLF 64
            |.|.|.:....:|: ..||.|:....|.....|.:     .|...:.::.:.: .|::|:.....
Human    30 DLRELREGEKPEDQ-AETEESWQGLARKTPGKACQAPEGGSCQPGKTENTITMTTSHQPQDRYKA 93

  Fly    65 TYLVFYLLGIGTMTPWNFFVTAEDYWKYKF---RNASINNTDLEE-------------ELTPLQK 113
            .:|:|::||:||:.|||||:||..|:..:.   :|.|:...:|.:             |...|..
Human    94 VWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDAQASAAPAAPLPERNSLSA 158

  Fly   114 SFTCDLALTATISGTTFLLLNAIFGHHVSLRTKMLGTLWMILILFGVTTGFVEINTDTWQEQFFL 178
            .|...:.|.|.:....|..||:.....:....::||:|..||::|.:|...|::..|..  .||:
Human   159 IFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAILLVFLITAILVKVQLDAL--PFFV 221

  Fly   179 ITLIIVVLLNISAATMSGALYGVAGLFPSEFITAVVSGQALGGILTALAFILVLAFDTGPNTTAF 243
            ||:|.:||:|...|.:.|:|:|:|||.|:.:...::|||.|.|...::|.|..:|..:..:.:||
Human   222 ITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAGFFASVAMICAIASGSELSESAF 286

  Fly   244 IFFIVGGVLILLCIVCYVILARKPFFRYY----LEG-GDKYKVIRAVP--SHNRNGSAE-GLPL- 299
            .:||....:|:|.|:||:.|.|..|:|||    ||| |::...:..:.  ...|.|..| |:.:
Human   287 GYFITACAVIILTIICYLGLPRLEFYRYYQQLKLEGPGEQETKLDLISKGEEPRAGKEESGVSVS 351

  Fly   300 --EPI-----LRQVMSKIYLHAISLALLYTTTLSVYPAVTVLMQSEY-GHSVWTDVYFLPVVNYL 356
              :|.     ::.::..|.:.|.|:..::|.|:.::|||||.::|.. |.|.| :.||:||..:|
Human   352 NSQPTNESHSIKAILKNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSSTW-ERYFIPVSCFL 415

  Fly   357 IFNCGDYFGRLFAG---WMERPLNQNTSLLFIVVRMAFVPLFLCSNSSEHSFLPVLVKHDYTFIA 418
            .||..|:.||....   |..:......||  ::.|:.||||.|..|.....:|.|:.:||..||.
Human   416 TFNIFDWLGRSLTAVFMWPGKDSRWLPSL--VLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIF 478

  Fly   419 MMVMFALSNGYFTNILLIMAPKRVKQHEKELASSIMAAALSCGMAVGSLLSLVF 472
            .|..||.||||..::.:...||:||..|.|.|.:|||..|..|:|:|::.|.:|
Human   479 FMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSFLF 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ent1	NP_001259820.1	Nucleoside_tran	69..476	CDD:301621	144/440 (33%)
SLC29A1	XP_011512643.1	2a57	98..536	CDD:273352	144/440 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	169	1.000	Domainoid score	I3807
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37985
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3732
OMA	1	1.010	-	-		QHG53699
OrthoDB	1	1.010	-	-		D318009at33208
OrthoFinder	1	1.000	-	-		FOG0000541
OrthoInspector	1	1.000	-	-		otm41263
orthoMCL	1	0.900	-	-		OOG6_100863
Panther	1	1.100	-	-	LDO	PTHR10332
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2123
SonicParanoid	1	1.000	-	-		X296
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910