DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11911 and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_608518.1	Gene:	CG11911 / 33206	FlyBaseID:	FBgn0031249	Length:	277	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	250	Identity:	72/250 - (28%)
Similarity:	111/250 - (44%)	Gaps:	39/250 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 VINGTEAEPHSAPYIVSLATNYLKHSHICGGTLINKDWIVTAAHC-----ISEPVGMSIIAGL-- 94
            ::.|....|...|:..|:|..:   .|.|||:::...|:||||||     ::......:.|||
Human   218 IVGGQSVAPGRWPWQASVALGF---RHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVS 279

  Fly    95 ------HTRAEVDELTQQRQVDFGRVHEKYTGGVGPYDIALLHVNESFIFNEWVQPATLPSREQV 153
                  |..|.|:.:..         |..|:.....||:|||.:..:..|::.|....||::||.
Human   280 HSAVRPHQGALVERIIP---------HPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQH 335

  Fly   154 HEGETHLY--GWGQP-KSYIFSGAKTLQTVTTQILNYEECKEELPESAPIAESNICSSSLQQSKS 215
            ....:..:  |||.. .|:.:| :..||.....:.:.:.|......|..:....:|:..|.....
Human   336 FPKGSRCWVSGWGHTHPSHTYS-SDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRAD 399

  Fly   216 ACNGDSGGPLVVEFTNAPS----ELIGIVSWGYIPCGLANMPSIYTKVSAYIDWI 266
            ||.||||||||     .|.    .|:|:||||. .|...|.|.:|.||:.::|||
Human   400 ACQGDSGGPLV-----CPDGDTWRLVGVVSWGR-GCAEPNHPGVYAKVAEFLDWI 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11911	NP_608518.1	Tryp_SPc	37..269	CDD:238113	71/249 (29%)
CG11911	NP_608518.1	Tryp_SPc	37..266	CDD:214473	70/248 (28%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133
		Tryp_SPc	217..448	CDD:214473	70/248 (28%)
		Tryp_SPc	218..451	CDD:238113	71/249 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920