DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11911 and F12

DIOPT Version :9

Sequence 1:	NP_608518.1	Gene:	CG11911 / 33206	FlyBaseID:	FBgn0031249	Length:	277	Species:	Drosophila melanogaster
Sequence 2:	NP_000496.2	Gene:	F12 / 2161	HGNCID:	3530	Length:	615	Species:	Homo sapiens

Alignment Length:	266	Identity:	88/266 - (33%)
Similarity:	123/266 - (46%)	Gaps:	33/266 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GAKLSDKLAKLVPSFATGFVINGTEAEPHSAPYIVSLATNYLKHSHICGGTLINKDWIVTAAHCI 82
            |.:|...|:.:..      |:.|..|...:.|||.:|   |..|| .|.|:||...|::|||||:
Human   360 GQRLRKSLSSMTR------VVGGLVALRGAHPYIAAL---YWGHS-FCAGSLIAPCWVLTAAHCL 414

  Fly    83 SE---PVGMSIIAGLHTRAEVDELTQQRQVDFGRVHEKYTGGVGPYDIALLHVNES-----FIFN 139
            .:   |..::::.|...|....|..|...|...|:||.::.....:|:|||.:.|.     .:.:
Human   415 QDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLS 479

  Fly   140 EWVQPATLPSREQVHEGETHL---YGWGQPKSYIFSGAKT----LQTVTTQILNYEECKEELPES 197
            .:|||..||| ......||.|   .|||    :.|.||:.    ||......|:.|.|.......
Human   480 PYVQPVCLPS-GAARPSETTLCQVAGWG----HQFEGAEEYASFLQEAQVPFLSLERCSAPDVHG 539

  Fly   198 APIAESNICSSSLQQSKSACNGDSGGPLVVEFTNAPSELI--GIVSWGYIPCGLANMPSIYTKVS 260
            :.|....:|:..|:....||.||||||||.|...|...|.  ||:||| ..||..|.|.:||.|:
Human   540 SSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWG-SGCGDRNKPGVYTDVA 603

  Fly   261 AYIDWI 266
            .|:.||
Human   604 YYLAWI 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11911	NP_608518.1	Tryp_SPc	37..269	CDD:238113	85/247 (34%)
CG11911	NP_608518.1	Tryp_SPc	37..266	CDD:214473	83/245 (34%)
F12	NP_000496.2	FN2	41..88	CDD:128373
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:278437
		Kringle	217..295	CDD:278480
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..359
		Tryp_SPc	372..609	CDD:214473	83/252 (33%)
		Tryp_SPc	373..612	CDD:238113	85/247 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910