DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11911 and PRSS36

DIOPT Version :9

Sequence 1:	NP_608518.1	Gene:	CG11911 / 33206	FlyBaseID:	FBgn0031249	Length:	277	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	270	Identity:	76/270 - (28%)
Similarity:	110/270 - (40%)	Gaps:	70/270 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 VINGTEAEPHSAPYIVSLATNYLKH--SHICGGTLINKDWIVTAAHCIS-----EPVG-MSIIAG 93
            ::.|:.|:|.:.|:.||     |.|  .|||||:||...|:::||||..     ||.. .|::.|
Human    47 IVGGSNAQPGTWPWQVS-----LHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLG 106

  Fly    94 LHTR------------AEVDELTQQRQVDFGRVHEKYTGGVGPYDIALLHVNESFIFNEWVQPAT 146
            :|::            |.:.......||:.|.            |:|||.:.........|.|..
Human   107 VHSQDGPLDGAHTRAVAAIVVPANYSQVELGA------------DLALLRLASPASLGPAVWPVC 159

  Fly   147 LP--SREQVHEGETHLYGWGQ-------PKSYIFSGAKTLQTVTTQILNYEECKEELPESAP--- 199
            ||  |...||.......|||.       |..::      ||.|..::|....|:....:..|
Human   160 LPRASHRFVHGTACWATGWGDVQEADPLPLPWV------LQEVELRLLGEATCQCLYSQPGPFNL 218

  Fly   200 ---IAESNICSSSLQQSKSACNGDSGGPLVVE-----FTNAPSELIGIVSWGYIPCGLANMPSIY 256
               |....:|:...:..:..|.||||||||.|     |.      .||.|:|: .||..|.|.::
Human   219 TLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQ------AGITSFGF-GCGRRNRPGVF 276

  Fly   257 TKVSAYIDWI 266
            |.|:.|..||
Human   277 TAVATYEAWI 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11911	NP_608518.1	Tryp_SPc	37..269	CDD:238113	76/270 (28%)
CG11911	NP_608518.1	Tryp_SPc	37..266	CDD:214473	74/268 (28%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	74/268 (28%)
		Tryp_SPc	47..289	CDD:238113	76/270 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920