DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11912 and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_608517.1	Gene:	CG11912 / 33205	FlyBaseID:	FBgn0031248	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	263	Identity:	75/263 - (28%)
Similarity:	112/263 - (42%)	Gaps:	54/263 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RIINGYEAAKGEAPYIVSLQTTSNSHFCAGSLLDEVTIVTAAHCL------TYNQGQAVAG--AH 85
            ||:.|...|.|..|:..|: .....|.|.||:|....:||||||:      ..:..:..||  :|
Human   217 RIVGGQSVAPGRWPWQASV-ALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSH 280

  Fly    86 SRTDQENVQIRKFTNA---QYVIHENYGGGVGPNDIGLILLKEEDAFDLNAVARDGSNPVSAVSL 147
            |       .:|....|   :.:.|..|.......|:.|:.|:         .|.:.|:.|.||.|
Human   281 S-------AVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQ---------TALNFSDTVGAVCL 329

  Fly   148 PSKT--FQGTSDGYLYGWGRDNSG-----------LLPLNLQKLDAIIVDYNECKAALPSNNSLA 199
            |:|.  |...|..::.|||..:..           ::||...:|         |.::...:.:|.
Human   330 PAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQL---------CNSSCVYSGALT 385

  Fly   200 ETNVCT-HTPGKADGSCNGDSGGPLVSQSSSRGAELIGIVSWGYTPCLSTTYPSVYTSVSSFLPW 263
            ...:|. :..|:|| :|.||||||||....... .|:|:|||| ..|....:|.||..|:.||.|
Human   386 PRMLCAGYLDGRAD-ACQGDSGGPLVCPDGDTW-RLVGVVSWG-RGCAEPNHPGVYAKVAEFLDW 447

  Fly   264 IDE 266
            |.:
Human   448 IHD 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11912	NP_608517.1	Tryp_SPc	29..264	CDD:214473	73/259 (28%)
CG11912	NP_608517.1	Tryp_SPc	30..267	CDD:238113	74/262 (28%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133
		Tryp_SPc	217..448	CDD:214473	73/259 (28%)
		Tryp_SPc	218..451	CDD:238113	74/262 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920