DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11912 and TMPRSS6

DIOPT Version :9

Sequence 1:NP_608517.1 Gene:CG11912 / 33205 FlyBaseID:FBgn0031248 Length:271 Species:Drosophila melanogaster
Sequence 2:NP_001275929.1 Gene:TMPRSS6 / 164656 HGNCID:16517 Length:824 Species:Homo sapiens


Alignment Length:290 Identity:82/290 - (28%)
Similarity:123/290 - (42%) Gaps:81/290 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 PEGRIINGYEAAKGEAPYIVSLQTTSNSHFCAGSLLDEVTIVTAAHCLTYNQGQAVAGAHSRTDQ 90
            |..||:.|..:::||.|:..|||.... |.|.|:|:.:..::|||||.                |
Human   564 PSSRIVGGAVSSEGEWPWQASLQVRGR-HICGGALIADRWVITAAHCF----------------Q 611

  Fly    91 ENVQIRKFTNAQYVIHENYGGGVGPND---------IGLILL---KEEDAFDLNAVARDGSNPV- 142
            |:      :.|..|:...:.|.|..|.         :..:||   .|||:.|.:.......:|| 
Human   612 ED------SMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVV 670

  Fly   143 -SA----VSLPSKT--FQGTSDGYLYGWGRDNSGLLPLNLQKLDAIIVDY-------NECKAALP 193
             ||    |.||:::  |:.....::.|||....|.|     :.||:.:.|       ..|  ..|
Human   671 RSAAVRPVCLPARSHFFEPGLHCWITGWGALREGAL-----RADAVALFYGWRNQGSETC--CCP 728

  Fly   194 SNNSLAETNV-------CTH------TP---------GKADGSCNGDSGGPLVSQSSSRGAELIG 236
            .:|:|.:.:|       |:.      ||         ||.| :|.||||||||.::.|....|.|
Human   729 ISNALQKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKGKKD-ACQGDSGGPLVCKALSGRWFLAG 792

  Fly   237 IVSWGYTPCLSTTYPSVYTSVSSFLPWIDE 266
            :|||| ..|....|..|||.::..:.||.:
Human   793 LVSWG-LGCGRPNYFGVYTRITGVISWIQQ 821

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11912NP_608517.1 Tryp_SPc 29..264 CDD:214473 79/283 (28%)
Tryp_SPc 30..267 CDD:238113 80/286 (28%)
TMPRSS6NP_001275929.1 SEA 77..177 CDD:307516
CUB 326..440 CDD:238001
LDLa 450..480 CDD:238060
LDLa 486..516 CDD:238060
Ldl_recept_a 520..557 CDD:278486
Tryp_SPc 568..822 CDD:238113 80/286 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D433637at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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