DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and PLCH2

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	XP_024306826.1	Gene:	PLCH2 / 9651	HGNCID:	29037	Length:	1755	Species:	Homo sapiens

Alignment Length:	1697	Identity:	389/1697 - (22%)
Similarity:	616/1697 - (36%)	Gaps:	543/1697 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ALQDGEKFIRWDDDSGTGTPVTMRVDAKGFF-LYWVDQN-----------NELDILDIATIRDVR 71
            |:|:|.:.::            :|..:||.. .|::|::           ||...:.|.:|::|.
Human   135 AMQEGMQMVK------------LRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVS 187

  Fly    72 TGQYAKRPKDNKLRQIVTLGPQDTLEEK-TVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGL--- 132
            .|:.:         ::....|..:.:.. ..::.|||...::..|:   |..::|:.|..||
Human   188 EGRQS---------EVFQRYPDGSFDPNCCFSIYHGSHRESLDLVS---TSSEVARTWVTGLRYL 240

  Fly   133 ---IKLAYSLAQLNGSAIMFLQKAHTKLCLQVDKS--GRIPVKNIIKLFAQNKEDRKRVEKALDV 192
               |....|||:...:...:|::...    :.||:  |.:.:..:::|..:           |:|
Human   241 MAGISDEDSLARRQRTRDQWLKQTFD----EADKNGDGSLSIGEVLQLLHK-----------LNV 290

  Fly   193 TGLPSGKVDSI--------SVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVE 249
             .||..:|..:        ......||:|...||.::.|.::..|.  :..::.:..:..|.|..
Human   291 -NLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLM--LTYSNHKDHLDAASLQR 352

  Fly   250 FLNKTQRDPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKL 314
            ||...|:        .........:::|:|:||...|..||.|.:|||..|.......|..|...
Human   353 FLQVEQK--------MAGVTLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHH 409

  Fly   315 DLCDDMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHG 379
            .:..||.||:|||||.|||||||.|.||..:|.|::|...|.|||||||:|.|:|...||::.||
Human   410 HVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHG 474

  Fly   380 YTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHP 444
            ||...:|..|||:|.|.:.||..:|||||||.||||:..||.|:|.|..:|.||.|   .|.|..
Human   475 YTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKL---DLSSVS 536

  Fly   445 LEPNMDLPPPAMLRRKIIIKNKKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVD--------- 500
            .|....||.|.||:.||::|.|            |.||.:...|...:::..:|.|
Human   537 SEDATTLPSPQMLKGKILVKGK------------KLPANISEDAEEGEVSDEDSADEIDDDCKLL 589

  Fly   501 ---------------------------------------------------AKAAQQVGLSASHE 514
                                                               :||.:.|   .|.|
Human   590 NGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDV---ESGE 651

  Fly   515 DGGVTRSTANGDVATGTGT-----GSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNT 574
            |.|.:|  .||.:..|:.:     ||            ::::::....|....||
Human   652 DAGASR--RNGRLVVGSFSRRKKKGS------------KLKKAASVEEGDEGQDS---------- 692

  Fly   575 TPNLPSGNEPPPEKAQKETEAGAEISALVNYVQPI--HFSSFENAEKKNRCYEMSSFDEKQATTL 637
                |.|......:.:|..:....:|.||.|.:.:  |....|.|..    :::|||.|.:|..:
Human   693 ----PGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASS----WQVSSFSETKAHQI 749

  Fly   638 LKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYN 702
            |:::|.:::.:|:.||||:||:..|.||||:.||.|||||||:||||:|:....:|||...|..|
Human   750 LQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSAN 814

  Fly   703 ARSGYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFLTDKR----------ANTFVE 757
            ...||:|||..|.:.  ..:|.:|..:.|.:...:.:.::|||.|...|          .:.|||
Human   815 GGCGYVLKPGCMCQG--VFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVE 877

  Fly   758 VDMYGLPADTVRKKFRTKTVRDN------------------------------------------ 780
            |::.|||.|..|:  :|:.|.||
Human   878 VEIIGLPVDCSRE--QTRVVDDNGEAGPWLRHTCDGSLRGEGWGYLVCPGALPRPPSVTVLGALP 940

  Fly   781 -------------------------------------------GMNPLYDEEPFVFKKVVLPELA 802
                                                       |.||.: ||..|| .|.:||:|
Human   941 SRWAVPEAAPGVALGVVWAGGSRLERCWAGPSPWDTPPGAASPGFNPTW-EETLVF-MVHMPEIA 1003

  Fly   803 SIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHV-----------------NLRSEVGQPIALAS 847
            .:|...::.   |...||.|.|....:.||||||                 ::..:|.|.:.|..
Human  1004 LVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQALGLKG 1068

  Fly   848 LFLCVVVKDYVPDDLSNFA----------------EALANPIKYQSELEKRDIQLSVLTDEAEAL 896
            |||    :...|..|.:.|                ...:.|.|.|....:...:|.:.|.:..:.
Human  1069 LFL----RGPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSK 1129

  Fly   897 GSADEDL------------------------------SKSFVFVQ-------------------- 911
            |.||:.:                              .||.|.|:
Human  1130 GVADDVVPPGPGPAPEAPAQEGPGSGSPRGKAPAAVAEKSPVRVRPPRVLDGPGPAGMAATCMKC 1194

  Fly   912 ---------VGGQKKELRPVESLAT-------SPKHRPSISAAAAMSVDVTV------------- 947
                     .||.::|..|....|:       .|:.|.....|....:|...
Human  1195 VVGSCAGVNTGGLQRERPPSPGPASRQAAIRQQPRARADSLGAPCCGLDPHAIPGRSREAPKGPG 1259

  Fly   948 --DRTDGGRG---EDSISIVAPSIQHQHSLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHK-- 1005
              .:..||.|   .||.|..:|.|..:.  .:....:.||..:.|.::..:.|:.||:|....
Human  1260 AWRQGPGGSGSMSSDSSSPDSPGIPERS--PRWPEGACRQPGALQGEMSALFAQKLEEIRSKSPM 1322

  Fly  1006 -SVKEKRLEMEKKLESLRKKHDKEKIKIAGQKSSPLEGKKPKFAITNKLVKRLSNKSLNCLSPH- 1068
             |...:.|..::.|..|.      .::...::.:|..|..|..|:        ...|.....|:
Human  1323 FSADTRPLSTQRPLPPLC------SLETIAEEPAPGPGPPPPAAV--------PTSSSQGRPPYP 1373

  Fly  1069 SEPGVEIPACPLDLGDSSEESAAADAGEDLAGGS------SSLDGRTQE---------SRLRSAC 1118
            :.||..: |.||:..:...:|.......:.|||:      |..|||:|.         .|::|..
Human  1374 TGPGANV-ASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEG 1437

  Fly  1119 R---EYTSQYRELQEKY-HEAIYSAAEKVLKTSQTG-----------------QTKQLKASLDKV 1162
            :   |....:|.|...: ..|:||.|        ||                 .:....:|.|.|
Human  1438 QVPTEPLGGWRPLAAPFPAPAVYSDA--------TGSDPLWQRLEPCGHRDSVSSSSSMSSSDTV 1494

  Fly  1163 TGEVMHQLQEARRNEVKNLATVHRDRDELIRMKREVASSVVERGVAERVRLKQTFDRRT------ 1221
            ....:..|...|..|  |||..|..|    ...|..::|.....:....:.|...:.|.
Human  1495 IDLSLPSLGLGRSRE--NLAGAHMGR----LPPRPHSASAARPDLPPVTKSKSNPNLRATGQRPP 1553

  Fly  1222 --DELQKQHDSVRNALAEHRSK-------ARQILDKEAESRSC--VSSNGFLVLFHG-----PHH 1270
              ||||.:..:.|.|....|..       ..|.....|:|:|.  ::::.|...|.|     .|.
Human  1554 IPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDLTADDFAPSFEGGSRRLSHS 1618

  Fly  1271 HGCTGSGSSALSGNN------------LTLNLDAGAAGSHSAISPA----------------KSH 1307
            .|..| |:..:||..            ||:...||...|.:::.||                :||
Human  1619 LGLPG-GTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTSLGPAGEGVAGGPGFVRRSSSRSH 1682

  Fly  1308 NSIAAAA 1314
            :.:.|.|
Human  1683 SRVRAIA 1689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	27/143 (19%)
		PLN02222	213..850	CDD:177868	227/818 (28%)
		EF-hand_like	225..317	CDD:286375	20/91 (22%)
		PI-PLCc_beta	317..702	CDD:176533	148/451 (33%)
		C2_PLC_like	736..855	CDD:175974	47/233 (20%)
PLCH2	XP_024306826.1	PH_PLC_eta	136..242	CDD:270170	23/129 (18%)
		EFh_PI-PLCeta2	260..400	CDD:320051	34/165 (21%)
		EF-hand motif	260..289	CDD:320051	5/43 (12%)
		EF-hand motif	296..326	CDD:320051	6/29 (21%)
		EF-hand motif	330..358	CDD:320051	5/29 (17%)
		EF-hand motif	367..400	CDD:320051	12/32 (38%)
		PI-PLCc_eta2	412..814	CDD:176570	148/451 (33%)
		C2_PLC_like	844..1054	CDD:175974	41/213 (19%)
		Atrophin-1	<1154..1577	CDD:331285	85/453 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151862
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750