DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and Plcb2

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_445930.1	Gene:	Plcb2 / 85240	RGDID:	621004	Length:	1183	Species:	Rattus norvegicus

Alignment Length:	1273	Identity:	469/1273 - (36%)
Similarity:	699/1273 - (54%)	Gaps:	173/1273 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EVPQALQDGEKFIRWDDDSGTGTPVTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKRP 79
            :|...|..||:||:|||::...:||.:|||.||::|||..|:.|::.||:.:|||.|.|::||.|
  Rat    12 KVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQSKEMEFLDVTSIRDTRFGKFAKIP 76

  Fly    80 KDNKLRQIVTLG-PQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLN 143
            |..|||::..:. |.:....||.||..|.|.|.:||.||...:.::.:.|.:.::.||......|
  Rat    77 KSQKLREVFNMDFPDNHFLLKTFTVVSGPDMVGLTFHNFVSYKENVGKDWAEDVLALAKHPMTAN 141

  Fly   144 GSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSKF 208
            .|...||.|...||.:|:...|:|||||..::|   ..||||||.||....|..||.|:|:...|
  Rat   142 ASRSTFLDKILVKLKMQLSPEGKIPVKNFFQMF---PADRKRVEAALSACHLAKGKNDAINPEDF 203

  Fly   209 QFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPARA 273
            ....:.:....|..|.|::.:|.|....:| ..|:...|.:|:|:.|||||||.:|:|.|.|.:.
  Rat   204 PESVYKSFLMSLCPRPEIDEIFTSYHAKAK-PYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQV 267

  Fly   274 KELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYLT 338
            :.||.:|||:..|.|:||||.:|.:.:|.|.:|.::|...|.:..||.||::|||||||||||||
  Rat   268 QALIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLRIHQDMTQPLNHYFINSSHNTYLT 332

  Fly   339 GHQLTGKSSVEIYRQCLLAGCRCVELDFWNGR--TEEPVIVHGYTFVPEIFAKDVLEAIAESAFK 401
            ..|.:|.||.|:|||.||:||||||||.|.|:  .|||:|.||:|...:|..|:.:|||||||||
  Rat   333 AGQFSGPSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAVEAIAESAFK 397

  Fly   402 TSEYPVILSFENHC-NPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKN 465
            ||.||||||||||. :||||||:|.|||.:||:.||.:||::.||:|.|.||.|..||.||:|||
  Rat   398 TSPYPVILSFENHVDSPRQQAKMAEYCRTMFGETLLTEPLENFPLKPGMPLPSPEDLRGKILIKN 462

  Fly   466 KKKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATG 530
            ||.              |...||:.||            :..|:|    :||...|.   .|...
  Rat   463 KKN--------------QFSGPASPNK------------KPDGVS----EGGFPSSV---PVEED 494

  Fly   531 TG-TGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETE 594
            || |.............:::.:..::.:|:.|.:...:.:|...|              |..|..
  Rat   495 TGWTAEDRTEVEEGEEEEEVEEEEEEESGNLDEEEIKKMQSDEGT--------------AGLEVT 545

  Fly   595 AGAEISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPA 659
            |..|:|:||||:||..|.|||.:.:|||.|.:|||.|.:|..||.:..::||:|||.|:|||||.
  Rat   546 AYEEMSSLVNYIQPTKFISFEFSAQKNRSYLVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPK 610

  Fly   660 GTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPF 724
            |||.||||:|||:|||||||:|||||||:||.||.|:.:||:|.:||||||.|||||.|::.:||
  Rat   611 GTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRQDKQFNPF 675

  Fly   725 AESTVDGIIAGTVSITVLSGQFLTDKRANTFVEVDMYGLPADTVRKKFRTK-TVRDNGMNPLYDE 788
            :...:|.::|.|:||||:|||||:::...|:|||:::|||.|. ::::||| :...|.:||::.|
  Rat   676 SVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDP-KRRYRTKLSPTANSINPVWKE 739

  Fly   789 EPFVFKKVVLPELASIRIAAYEEGGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLFLCVV 853
            |||:|:|:::|||||:|||..|||||.||||::|:..|..||.|:.||||...|:.:.:||:.:.
  Rat   740 EPFIFEKILVPELASLRIAVMEEGGKFIGHRIIPINALHSGYHHLCLRSESNMPLTMPALFVFLE 804

  Fly   854 VKDYVPDDLSNFAEALANPIKYQSELEKRDIQLSVLTDEAEALGSADEDLSKSFVFVQVGGQKKE 918
            :||||||..::...||||||||.|..:|:.::|.      |..||..|   |.|..:.|..|
  Rat   805 MKDYVPDTWADLTVALANPIKYFSAHDKKSVKLK------EVTGSLPE---KLFSGIPVASQ--- 857

  Fly   919 LRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDSISIVAPSIQHQHSLDQSVSTSIRQV 983
                             |..|.:|         .|.|.     .||..:.:....:.|
  Rat   858 -----------------SNGAPVS---------AGNGS-----TAPGTKAKEEATKEV------- 884

  Fly   984 ESSQFDVDLVLAEP----LEKILDHKSVKEKRLEMEKKLESLRKKHDKEKIKIAGQKSSPLEGKK 1044
                       |||    ||::.:.|.|.:           |:::|:||..::..:.:...|
  Rat   885 -----------AEPQTTSLEELRELKGVVK-----------LQRRHEKELRELERRGARRWE--- 924

  Fly  1045 PKFAITNKLVKRLSNKSLNCLSPHSEPGVEIPACPLDLGDSSEESAAADAGEDLAGGSSSLDG-- 1107
                   :|::|.:.:    |:...:|..   :|.|..|..|.:.......|.:......|:|
  Rat   925 -------ELLQRGAAQ----LAELQDPAA---SCKLRPGKGSRKKRIVPCEETIVVPREVLEGPD 975

  Fly  1108 -RTQE--SRLRSACREY-TSQYRELQEKYHEAIYSAAEKVL---KTSQTGQTKQLKASLDKVTGE 1165
             |.|:  .||....::. ..|||.:.::..:.:.....|::   :..|..:.|..|.:.:..|.|
  Rat   976 PRVQDLKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKSFKETSETDTKE 1040

  Fly  1166 VMHQLQEARRNEVKNLATVHRDRDELIRMKREVASSVVERGVAERVRLKQTFDRRTDELQKQHDS 1230
            :..:|:..|...::.:..|..|:....|:|||:.:|.::..|....::.:|.:|..::|:::..:
  Rat  1041 MKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEEKQTA 1105

  Fly  1231 V------------RNALAEHRSKARQILDKEAES-RSC 1255
            .            ..||||:.:|.:.:..:..|| |:|
  Rat  1106 CLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESMRAC 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	50/125 (40%)
		PLN02222	213..850	CDD:177868	298/641 (46%)
		EF-hand_like	225..317	CDD:286375	36/91 (40%)
		PI-PLCc_beta	317..702	CDD:176533	185/388 (48%)
		C2_PLC_like	736..855	CDD:175974	59/119 (50%)
Plcb2	NP_445930.1	PH_PLC_beta	17..144	CDD:270167	50/126 (40%)
		PLN02222	219..804	CDD:177868	297/633 (47%)
		EF-hand_like	220..311	CDD:286375	36/91 (40%)
		PI-PLCc_beta2	311..653	CDD:176561	185/388 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..537		20/107 (19%)
		C2_PLC_like	685..806	CDD:175974	60/121 (50%)
		EnvC	827..>1072	CDD:227278	61/333 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	857..888		11/82 (13%)
		PLC-beta_C	976..1151	CDD:285865	35/168 (21%)
		DUF904	1040..1119	CDD:299763	14/78 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1150..1183
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345379
Domainoid	1	1.000	203	1.000	Domainoid score	I2860
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	882	1.000	Inparanoid score	I382
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	1	1.000	-	-		otm44758
orthoMCL	1	0.900	-	-		OOG6_102409
Panther	1	1.100	-	-	O	PTHR10336
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1825
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900