Protein Alignment Plc21C and PLCD4

DIOPT Version :9

• Sequence 1: NP_995605.1
• Gene: Plc21C / 33204
• FlyBaseID: FBgn0004611
• Length: 1318
• Species: Drosophila melanogaster
• Sequence 2: XP_011510314.1
• Gene: PLCD4 / 84812
• HGNCID: 9062
• Length: 820
• Species: Homo sapiens
• Alignment Length: 910
• Identity: 277/910 - (30%)
• Similarity: 421/910 - (46%)
• Gaps: 196/910 - (21%)

  Fly    25 KFIRWDDDSGTGTPVTMRVDAKGFFLYWVDQNNELDILDIATIRDVRTGQYAKRPKDNKLRQIVT 89
            ::.|..:|   |..|.....|:|      .......|.|:.|||:         ..|::|  :.:
Human    36 RYFRLQND---GMTVWHARQARG------SAKPSFSISDVETIRN---------GHDSEL--LRS 80

  Fly    90 LGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDG---LIKLAYSL---AQLNGSAIM 148
            |..:..||:....|.||    ..:.::......:.||:|..|   |:.|..|:   .:|:.....
Human    81 LAEELPLEQGFTIVFHG----RRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSD 141

  Fly   149 FLQKAHTKLCLQVDKS--GRIPVKNIIKLF-----AQNKEDRKRVEKALDVTGLPSGKVDSISVS 206
            :.|:.        ||:  |::..:.:.:|.     ..::|....:.:|.|.:  .||.::.
Human   142 WFQRG--------DKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTS--QSGTLEG---- 192

  Fly   207 KFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPA 271
                |:|...||.||:|:||:.||:|...:.::  :::.:.::||.:.|::......|
Human   193 ----EEFVQFYKALTKRAEVQELFESFSADGQK--LTLLEFLDFLQEEQKERDCTSEL------- 244

  Fly   272 RAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTY 336
             |.|||.:|||:.....:..||:||||.||...|..|..|:.|.:..||.||::||||.||||||
Human   245 -ALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTY 308

  Fly   337 LTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFK 401
            |.|.||.|:||||.|.:.|..||||||:|.|:|.:.|||:.||:|....|..|||:..:|:.||:
Human   309 LVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQYAFQ 373

  Fly   402 TSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNK 466
            ||:||||||.|.||:..||..:|.:..||.|:.||...||.  :.|. .||.|..|||||::|.|
Human   374 TSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDG--VLPT-QLPSPEELRRKILVKGK 435

  Fly   467 KKHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGT 531
                                     |||....::.:..:
Human   436 -------------------------KLTLEEDLEYEEEE-------------------------- 449

  Fly   532 GTGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPN-------TTPNL-PS------GN 582
                       |.|  ::.:|........:::...::::|.|       |.|.. ||      ..
Human   450 -----------AEP--ELEESELALESQFETEPEPQEQNLQNKDKKKVVTCPLFCPSICCQIVAQ 501

  Fly   583 EP--PPEKAQKETEAGAEI-----SALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKE 640
            .|  .||......:....|     |:||.|::.:.|.||.::::....||:|||.|.:|..|:||
Human   502 APISKPESLLLSRQKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKE 566

  Fly   641 RPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARS 705
            ...|||.:|..|||||||:|.|.||||:.||..||||||:||:|.||..|.|.:..|.|..|...
Human   567 AGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGC 631

  Fly   706 GYLLKPEFMRRSDRRLDPFAESTVDGIIAGTVSITVLSGQFL--TDKR-----ANTFVEVDMYGL 763
            ||:|||:|:|.......|  |..:....|.|:.|.|:|||.|  .||.     .:..|:|.::|:
Human   632 GYVLKPDFLRDIQSSFHP--EKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGV 694

  Fly   764 PADTVRKKFRTKTVRDNGMNPLYDEEPFVFKKVVLPELASIRIAAYEEGGK----LIGHRVLP-- 822
            ..||.|::  |..|.:||.|| |..:...| :|::||||.:|....:...|    .||...||
Human   695 RLDTARQE--TNYVENNGFNP-YWGQTLCF-RVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWT 755

  Fly   823 ------------------------VIGLCPGYRHVNLRSEVGQPIALASLFLCVVVKDYVPDDLS 863
                                    |:...|||||::|.|:.|..:..||:|:.:.:::.:..|.|
Human   756 CMQQGEPAPLAPGQYPSSGCLPNAVLLPLPGYRHIHLLSKDGISLRPASIFVYICIQEGLEGDES 820

  Fly   864  863
            Human   821  820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	27/125 (22%)
		PLN02222	213..850	CDD:177868	236/694 (34%)
		EF-hand_like	225..317	CDD:286375	28/91 (31%)
		PI-PLCc_beta	317..702	CDD:176533	146/405 (36%)
		C2_PLC_like	736..855	CDD:175974	46/155 (30%)
PLCD4	XP_011510314.1	PH	17..123	CDD:278594	23/110 (21%)
		PH_PLC_delta	18..133	CDD:270169	26/120 (22%)
		EF-hand_7	143..199	CDD:290234	12/73 (16%)
		EF-hand_10	153..202	CDD:291454	10/58 (17%)
		PLN02222	207..765	CDD:177868	219/640 (34%)
		EF-hand_like	207..289	CDD:286375	28/91 (31%)
		PI-PLCc_GDPD_SF	289..628	CDD:301322	146/405 (36%)
		C2_PLC_like	658..809	CDD:175974	47/154 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151870
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	1	1.000	-	-		FOG0000126
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750