DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plc21C and Plcl1

DIOPT Version :9

Sequence 1:	NP_995605.1	Gene:	Plc21C / 33204	FlyBaseID:	FBgn0004611	Length:	1318	Species:	Drosophila melanogaster
Sequence 2:	NP_445908.2	Gene:	Plcl1 / 84587	RGDID:	708420	Length:	1096	Species:	Rattus norvegicus

Alignment Length:	1157	Identity:	304/1157 - (26%)
Similarity:	478/1157 - (41%)	Gaps:	301/1157 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 TMRVDAKGFFLYWVDQNNELD--ILDIATIRDVRTGQYAKRPKDNKLRQIVTLGPQDTLEEKTVT 102
            |:..|.:.  |.|.....:|:  .|||:.|:::|.|:..:..::|.|...:       .|:...:
  Rat   137 TLDTDLQA--LRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQI-------CEDCAFS 192

  Fly   103 VCHGSDFVNMTFVNFCCTRRDIAQLWTDGL-------------------------IKLAYSLAQL 142
            :.||.::.::..|   ....|:|.:|..||                         :|..:..|.:
  Rat   193 ILHGENYESLDLV---ANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADV 254

  Fly   143 NGSAIMFLQKAHTKLCLQVDKSGRIPVKNIIKLFAQNKEDRKRVEKALDVTGLPSGKVDSISVSK 207
            :|:.|| |:....:|..|::     |.....|:..:.||.:|..||.               .::
  Rat   255 DGNGIM-LEDTSVELIKQLN-----PTLKESKIRLKFKEIQKSKEKL---------------TTR 298

  Fly   208 FQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDPRLNEILYPYANPAR 272
            ...|:|...:..|..|.||..|...|..|  ::.:....|:.||...|....:.|.:
  Rat   299 VTEEEFCEAFCELCTRPEVYFLLVQISKN--KEYLDANDLMLFLEVEQGVTHVTEDM-------- 353

  Fly   273 AKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCDDMDQPMSHYFINSSHNTYL 337
            ..::|::||.::...|||.|::|||.:||:..:..|..|.:..:..||.||:|||:||:||||||
  Rat   354 CLDIIRRYELSEDGRQKGFLAIDGFTQYLLSPECDIFDPEQKKVAQDMTQPLSHYYINASHNTYL 418

  Fly   338 TGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKT 402
            ...|..|.:.:..|.:.|..|||.:|||..:|...||::.:.......:..:.|||.|.:.||..
  Rat   419 IEDQFRGPADINGYVRALKMGCRSIELDVSDGPDNEPILCNRNNMAMLLSFRSVLEVINKFAFVA 483

  Fly   403 SEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHPLEPNMDLPPPAMLRRKIIIKNKK 467
            ||||:||...|||:..||..:....:::||:.|..:.    ||.....||.|..|:..||:|.||
  Rat   484 SEYPLILCLGNHCSLPQQRVMVQQMKKVFGNKLYTEA----PLSSESYLPSPEKLKHMIIVKGKK 544

  Fly   468 KHHHHHHHHHHKKPAQVGTPAANNKLTTANSVDAKAAQQVGLSASHEDGGVTRSTANGDVATGTG 532
                              .|:.::.|                     :|.||......:::
  Rat   545 ------------------LPSESDLL---------------------EGEVTDEDEEAEMS---- 566

  Fly   533 TGSAAGTAGHAPPLQQIRQSSKDSTGSSDSDSSSEDESLPNTTPNLPSGNEPPPEKAQKETEAGA 597
                             |:.|.|..|.                              ||......
  Rat   567 -----------------RRVSGDYNGE------------------------------QKHIWLCR 584

  Fly   598 EISALVNYVQPIHFSSFENAEKKNRCYEMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTR 662
            |:|.||:..:.:.:..||.:.|....:|:.||.|..|:.:..|.|.:||||||..||||||:..|
  Rat   585 ELSDLVSICKSVQYRDFELSMKTQNYWEICSFSETLASRIANEYPEDFVNYNKKFLSRVYPSAMR 649

  Fly   663 FDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAES 727
            .||||..||.|||.|||:||:||||....|.|:.|.|..|...||:|:|..||   ..:..|:.:
  Rat   650 IDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMR---DEVSYFSAN 711

  Fly   728 TVDGIIAGT----VSITVLSGQ-FLTDKRA-------NTFVEVDMYGLPADTVRKKFRTKTVRDN 780
            | .||:.|.    :.|.::||| |...|.|       :.:|.|:::|:|||...:  |||||:.|
  Rat   712 T-KGIVPGVSPLLLHIKIISGQNFPKPKGACAKGDVIDPYVCVEIHGIPADCSEQ--RTKTVQQN 773

  Fly   781 GMNPLYDEEPFVFKKVVLPELASIRIAAYEE---GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQP 842
            ..||::| |.|.| :|.||||..:|....::   |.:.||...:|...|.||||||.|||.||..
  Rat   774 SDNPIFD-ETFEF-QVNLPELTMVRFVILDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDI 836

  Fly   843 IALASLFLCVVVKDYVPDDLSNFAEALANPI------KYQSELEKRDIQLSVLTD--------EA 893
            :...:||:.:.:     .:.|...:|....:      |.:.....|:|.|..:.|        ..
  Rat   837 MEHVTLFVHIAI-----TNRSGGGKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLR 896

  Fly   894 EALGSADEDLSKSFVFVQVGGQKKELRPVESLATSPKHRPSISAAAAMSVDVTVDRTDGGRGEDS 958
            ||: ...|::..:.|.|      |||..:..:|:..:...::|:..     :|.|.|      .|
  Rat   897 EAI-DMRENMQNAIVSV------KELCGLPPIASLKQCLLTLSSRL-----ITSDST------PS 943

  Fly   959 ISIV-------------APSIQHQHSLDQSVSTSIRQVESSQFDVDLVLAEPLEKILDHKSVKEK 1010
            :|:|             .|.:|.            |.:.:    .||::.|....|....:|:||
  Rat   944 VSLVMKDCFPYLEPLGTIPDVQK------------RMLAA----YDLMIQESRVLIEMADTVQEK 992

  Fly  1011 RLEMEKK-LESLRKKHDKEKIKIAGQKSSPLEGKKPKFAI--------------------TNKLV 1054
            .::.:|. :|...:.|:      .|.|.. |:|:|...||                    .|:.|
  Rat   993 IVQCQKAGMEFHEELHN------LGAKEG-LKGRKLNKAIESFAWNITVLKGQGDLLKNAKNEAV 1050

  Fly  1055 KRLSNKSLNCLSPHSEPGVEIPACPLDLGDSSEESAAADAGEDLAGGSSSLD 1106
            :.:....|.|||           |.|..|..|    ||:     |.|..||:
  Rat  1051 ENIKQIQLACLS-----------CGLSKGPGS----AAE-----AKGKRSLE 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plc21C	NP_995605.1	PH_PLC_beta	20..145	CDD:270167	24/131 (18%)
		PLN02222	213..850	CDD:177868	206/651 (32%)
		EF-hand_like	225..317	CDD:286375	24/91 (26%)
		PI-PLCc_beta	317..702	CDD:176533	119/384 (31%)
		C2_PLC_like	736..855	CDD:175974	49/133 (37%)
Plcl1	NP_445908.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..101
		Interaction with PPP1C	83..222		22/96 (23%)
		PH_PLC_eta	116..224	CDD:270170	22/98 (22%)
		EFh_PI-PLC	244..386	CDD:333715	41/172 (24%)
		EF-hand motif	244..273	CDD:320029	8/29 (28%)
		EF-hand motif	280..312	CDD:320029	8/46 (17%)
		EF-hand motif	316..344	CDD:320029	8/29 (28%)
		EF-hand motif	353..386	CDD:320029	12/40 (30%)
		PI-PLCc_PRIP_metazoa	399..689	CDD:176539	119/383 (31%)
		Interaction with GABA A beta subunit	544..568		6/83 (7%)
		C2_PLC_like	721..849	CDD:175974	49/136 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1067..1096		8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345377
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850